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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Estradien Tablet 21's is a contraceptive agent used as a means of birth control in women who wish to prevent unwanted pregnancy. It works by causing changes in the cervical mucus and uterine lining. This makes it harder for sperm to reach the uterus and a fertilised egg to attach to the uterus. Estradien Tablet 21's is also used to treat heavy menstrual bleeding by reducing the intensity and duration of menstrual bleeding.

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Manufacturer/Marketer :

Burot Pharmaceutical

Consume Type :

ORAL

Return Policy :

Not Returnable

About Estradien Tablet 21's

Estradien Tablet 21's belongs to the group of combined oral contraceptives used as a means of birth control in women who wish to prevent unwanted pregnancy. It is also used in the treatment of irregular menstrual cycles. It is also found to be useful in the treatment of moderate to severe acne. A combined oral contraceptive (COCP) is nothing but a birth-control pill, colloquially referred to as the ‘’pill,’’ and it is used as a means of oral birth control by women. Menorrhagia is heavy menstrual bleeding lasting longer than seven days, whereas dysmenorrhea is painful periods. Acne vulgaris is a skin condition characterized by pimples, blackheads, and whiteheads on the face.

Estradien Tablet 21's is composed of ‘’Ethinyl estradiol and Dienogest.’’ It is essentially an ovulation inhibitor, which inhibits the release of potent eggs from the ovary, thereby preventing pregnancy. It also changes the cervical (cervix is the connection between the uterus and vagina) ambience, making cervical secretions thicker and hostile to any incoming sperm. Hence, it is a very potent contraceptive. In addition, the dienogest component inhibits gonadotropin (sex hormone) production and also suppresses the growth of uterine cells. Therefore, Estradien Tablet 21's helps prevent pregnancy. 

In some cases, Estradien Tablet 21's may cause certain common side effects such as nausea, breast soreness, headache and irregular periods. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.

If you are allergic to Estradien Tablet 21's or any of its components, please inform the doctor before using Estradien Tablet 21's. Keep the doctor informed if you are on treatment for any cardiovascular disease, mental health disorder, liver disease, gallbladder disease or breast/uterine/cervical cancer. Before taking Estradien Tablet 21's, inform your doctor of your entire medical and surgical history. Please consult your doctor before taking Estradien Tablet 21's during pregnancy or if you are breastfeeding. Do not consume Estradien Tablet 21's with alcohol.

Uses of Estradien Tablet 21's

Contraception, treatment of menorrhagia and acne vulgaris.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Estradien Tablet 21's is a combined oral contraceptive and birth control pill. It contains Ethinyl estradiol and Dienogest. Estradien Tablet 21's is used to prevent pregnancy by suppressing ovulation and changing the consistency of cervical secretions. In patients suffering from menorrhagia, Estradien Tablet 21's reduces the intensity and duration of menstrual bleeding. It also relieves pain during periods (dysmenorrhea). Estradien Tablet 21's reduces hair and skin greasiness, providing relief to blackheads/whiteheads and acne-prone skin.

How Estradien Tablet 21's Works

Estradien Tablet 21's is composed of ‘’Ethinyl estradiol and Dienogest.’’ It is essentially an ovulation inhibitor, which inhibits the release of potent eggs from the ovary, thereby preventing pregnancy. It also changes the cervical (cervix is the connection between the uterus and vagina) ambience, making cervical secretions thicker and hostile to any incoming sperm. Hence, it is a very potent contraceptive. In addition, the dienogest component inhibits gonadotropin (sex hormone) production and also suppresses the growth of uterine cells. Therefore, Estradien Tablet 21's helps prevent pregnancy.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Estradien Tablet 21's

  • Headache
  • Nausea and vomiting
  • Irregular menstrual cycles
  • Cramps 
  • Abdominal bloating
  • Breast tenderness
  • Hypertension

What if I have taken an overdose of Estradien Tablet 21's

Take Estradien Tablet 21's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Symptoms of overdose may include vomiting, nausea, and vaginal bleeding. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Estradien Tablet 21's is not recommended for use in women over 35 who smoke. Estradien Tablet 21's should not be used in case of any known allergy to either of the components. Estradien Tablet 21's is not advisable for use in case of high risk or previous history of any mental health disorders, arterial or thrombotic disorders, cardiovascular health disorders, liver disease, gallbladder disease, history of breast/uterine/cervical cancer or any hormone-sensitive cancer. Women with a history of angioedema should exercise caution while taking Estradien Tablet 21's as it may worsen the angioedema. Please consult the doctor before using Estradien Tablet 21's during pregnancy or breastfeeding. It is advisable not to consume Estradien Tablet 21's with alcohol. Inform the doctor right away if you notice any dark urine, yellowing of the eyes/skin, severe mood changes or any sudden heavy bleeding. Women with a tendency for chloasma/melasma (a skin condition commonly seen in middle-aged women) should avoid sun exposure after taking Estradien Tablet 21's.

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
DienogestEfavirenz
Critical

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
How does the drug interact with Estradien Tablet 21's:
Taking Estradien Tablet 21's with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Estradien Tablet 21's with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
DienogestEfavirenz
Critical
How does the drug interact with Estradien Tablet 21's:
When Efavirenz is taken with Estradien Tablet 21's, it can lower the metabolism of Estradien Tablet 21's and increase the risk or severity of side effects.

How to manage the interaction:
Taking Efavirenz with Estradien Tablet 21's can possibly result in an interaction, however, it can be taken when advised by a doctor. Do not stop using any medications without talking to a doctor.
EthinylestradiolGriseofulvin
Severe
How does the drug interact with Estradien Tablet 21's:
Taking ethinyl estradiol with griseofulvin may reduce blood levels and the effects of ethinyl estradiol.

How to manage the interaction:
Although taking Estradien Tablet 21's and Griseofulvin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you use hormone replacement therapy (ethinyl estradiol) for menopause, inform a doctor if your symptoms are no longer controlled or if you deal with unusual bleeding. Do not stop using any medications without a doctor's advice.
EthinylestradiolAmprenavir
Severe
How does the drug interact with Estradien Tablet 21's:
Taking Estradien Tablet 21's and Amprenavir together may make amprenavir less effective.

How to manage the interaction:
Co-administration of Estradien Tablet 21's with Amprenavir can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EthinylestradiolRifampicin
Severe
How does the drug interact with Estradien Tablet 21's:
Taking Estradien Tablet 21's with rifampicin can decrease the blood levels of Estradien Tablet 21's, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Rifampicin and Estradien Tablet 21's, they can be taken together if prescribed by a doctor. Do not discontinue any medicine without consulting a doctor.
EthinylestradiolPhenobarbital
Severe
How does the drug interact with Estradien Tablet 21's:
When Estradien Tablet 21's is taken with phenobarbital, Estradien Tablet 21's may become les effective.

How to manage the interaction:
Although taking phenobarbital and Estradien Tablet 21's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you use hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer controlled or if you experience unusual bleeding. Do not stop using any medications without talking to a doctor.
EthinylestradiolTopiramate
Severe
How does the drug interact with Estradien Tablet 21's:
When Estradien Tablet 21's and Topiramate are taken together, Estradien Tablet 21's is less effective as a form of birth control.

How to manage the interaction:
Co-administration of Topiramate with Estradien Tablet 21's can result in an interaction, but it can be taken if a doctor has advised it. If you are taking hormone replacement therapy for menopause, and you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding contact a doctor Do not stop using any medications without a doctor's advice.
EthinylestradiolPhenytoin
Severe
How does the drug interact with Estradien Tablet 21's:
Phenytoin may lower ethinyl estradiol levels in the blood and its effects. You may be more likely to experience breakthrough bleeding and unexpected pregnancy if you use low-dose oral contraceptives.

How to manage the interaction:
Although taking Phenytoin and Estradien Tablet 21's together can result in an interaction, it can be taken if a doctor has prescribed it. If you are on hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer being controlled or if you are experiencing abnormal bleeding. Do not stop using any medications without a doctor's advice.
EthinylestradiolExemestane
Severe
How does the drug interact with Estradien Tablet 21's:
When used with Estradien Tablet 21's, the effectiveness of Exemestane might be reduced.

How to manage the interaction:
Although taking Exemestane and Estradien Tablet 21's together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
EthinylestradiolAnastrozole
Severe
How does the drug interact with Estradien Tablet 21's:
Estradien Tablet 21's may interfere with anastrozole's function and make it less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Anastrozole and Estradien Tablet 21's, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • As nausea and vomiting may occur with the use of Estradien Tablet 21's, make sure to take it on light, small meals. 
  • Let your doctor know if you are planning to get pregnant. 
  • After starting Estradien Tablet 21's, use another alternative non-hormonal contraceptive for at least ten days.
  • Maintaining a healthy weight can go a long way in promoting healthy female reproductive health. Make sure you exercise for at least 30 minutes every day. However, do not engage in very strenuous physical exercise as this can worsen bleeding. 
  • Regularly working night shifts can affect hormone production. Try to avoid night shifts. 
  • Maintain good sexual hygiene and prevent any sexually transmitted diseases by practising only safe sex.
  • Limit your intake of caffeine and alcohol. 
  • Avoid smoking. 
  • Avoid grapefruit juice while taking Estradien Tablet 21's as this may interact with Estradien Tablet 21's and affect its absorption. 
  • Increase your intake of red vegetables, fruits, dry fruits, spinach, nuts and beans as these help in new blood formation. 
  • Keeping your skin hydrated by drinking enough water can also do wonders for the overall quality of your skin. 
  • Always wash your makeup before sleeping. Never go to bed with makeup on.
  • Exfoliate your skin lightly but regularly. This helps wash away dry and dead cells, cleansing the skin. 
  • Severe nausea or vomiting following the use of the tablet can be considered a missed dose. In this case, additional contraceptive measures are advised. 

Habit Forming

No

Therapeutic Class

CONTRACEPTIVES

Estradien Tablet 21's Substitute

Substitutes safety advice
  • Estro Plus Tablet 21's

    by AYUR

    24.21per tablet
  • Dienoplus Tablet 21's

    23.31per tablet
  • Dienille Tablet 21's

    26.96per tablet
  • Deereg Tablet 21's

    23.31per tablet
  • Dinesys Plus Tablet 21's

    34.24per tablet
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Alcohol

Caution

Exercise caution while consuming alcohol with Estradien Tablet 21's as there may be a minor interaction.

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Pregnancy

Caution

There is no evidence of birth defects after unintended use of Estradien Tablet 21's during pregnancy. However, Estradien Tablet 21's should not be used to induce abortion or to treat a miscarriage. Please consult your doctor in case of any concerns.

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Breast Feeding

Caution

Other forms of contraception are advised as long as breastfeeding continues. Estradien Tablet 21's may affect the production of breast milk. Please consult the doctor.

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Driving

Caution

There is not enough literature to explain the effects of Estradien Tablet 21's on driving. Do not drive if you experience any side effects that alter your thinking ability or concentration.

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Liver

Caution

Estradien Tablet 21's should be used with caution in those with liver disease. Please consult your doctor if you have any concerns.

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Kidney

Caution

Estradien Tablet 21's should be used with caution in those with kidney disease. Please consult your doctor if you have any concerns.

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Children

Caution

Use before 18 is allowed. Use below the age of menarche (first period) is not indicated.

FAQs

Estradien Tablet 21's is used as a means of birth control in women who wish to prevent unwanted pregnancy. It is also used in the treatment of irregular menstrual cycle and moderate to severe acne.
Estradien Tablet 21's works by suppressing ovulation and by changing cervical mucous thickness, thereby preventing pregnancy and acting as an effective birth control method.
Estradien Tablet 21's is advisable not to use atleast for a minimum of 4 weeks after delivery after which you can resume its use. Please consult your doctor.
Estradien Tablet 21's is not known to affect conception rates as it’s been found that women got pregnant pretty soon after discontinuing Estradien Tablet 21's. Please consult your doctor.
Estradien Tablet 21's is not recommended or indicated in the treatment of any breast tumours or cancers.
This is not one of the indicated uses of Estradien Tablet 21's. For any concerns, please consult your gynaecologist.

Country of origin

India

Manufacturer/Marketer address

Burot Pharmaceutical
Other Info - EST0272

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