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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:19 PM IST
Estofol 2 mg Tablet is an hormone medicine used in the treatment of post-menopausal symptoms, osteoporosis, hypoestrogenism and advanced androgen-dependent carcinoma of the prostate. This medicine contains estradiol, which works by enhancing the lowered levels of the sex hormone oestrogen in the peri or post-menopausal female body, thus helps reduce symptoms of menopause such as vaginal dryness, hot flashes (hot face, neck and chest) and weak bones.
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Prescription drug

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Manufacturer/Marketer

Neon Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Estofol 2 mg Tablet

Estofol 2 mg Tablet is a hormone replacement therapy used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Menopause is the stopping of a woman’s period for life and is marked after an entire span of 12 months without periods.

Estofol 2 mg Tablet is composed of Estradiol valerate that works by enhancing the lowered levels of the sex hormone oestrogen in the peri or post-menopausal female body. This helps combat the various symptoms of menopause such as vaginal dryness, hot flashes (hot face, neck and chest) and weak bones. 

Take Estofol 2 mg Tablet as prescribed. In some cases, Estofol 2 mg Tablet may cause certain common side effects such as nausea, vomiting, breast soreness, headache and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.

Keep your doctor informed if you are allergic to any medicines. Discuss with the doctor if you have/had cardiovascular disease, thrombotic disorders, pulmonary embolism, mental health disorders, liver disease, gall bladder disease, anaemia, bleeding disorders, or breast/uterine/cervical cancer. Estofol 2 mg Tablet is intended for post-menopausal women; therefore, do not take Estofol 2 mg Tablet if you are pregnant or breastfeeding.

Uses of Estofol 2 mg Tablet

Treatment of Post-menopausal symptoms, Osteoporosis, Hypoestrogenism and Advanced androgen-dependent carcinoma of the prostate

Medicinal Benefits

Estofol 2 mg Tablet is a hormone replacement therapy (HRT) used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Estofol 2 mg Tablet helps in the synthesis and maintenance of sex hormone oestrogen in the body, by acting as its precursor. It acts directly on plasma membrane receptors and promotes the conversion of oestradiol to its most potent counterpart, thereby enhancing the body’s levels of oestrogen and helping fight the symptoms of menopause.

Directions for Use

Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Estofol 2 mg Tablet

  • Headache
  • Irregular vaginal bleeding/spotting
  • Stomach cramps
  • Bloating
  • Breast pain
  • Nausea
  • Vomiting
  • Hair loss

Drug Warnings

Estofol 2 mg Tablet should not be used in case of any known allergy to any of the components. Inform your doctor if you have/had arterial or thrombotic disorders, cardiovascular health disorders, porphyria, anaemia, hypertension, diabetes, asthma, epilepsy, bleeding disorders, liver problem, kidney problem, depression, gallbladder disease, breast/uterine/cervical cancer or any hormone-sensitive cancer. Estofol 2 mg Tablet is intended for use in postmenopausal women, do not take Estofol 2 mg Tablet  if you are pregnant or breastfeeding. Estofol 2 mg Tablet should be used with caution if you are on any anti-epileptic, anti-tuberculosis, anti-hypertensive, cardiac, antifungal, antibiotic, anti-depressant or anti-retroviral therapy. Women with a tendency for chloasma/melasma (skin condition commonly seen in middle-aged women), should avoid sun exposure after taking Estofol 2 mg Tablet . Women with a history of angioedema should exercise caution while taking Estofol 2 mg Tablet as it may worsen the angioedema.

Drug Interactions

Drug-Drug Interactions:  Estofol 2 mg Tablet is known to interact with antiepileptics (carbamazepine, phenytoin), anti-depressant (St. John’s wort), anti-tuberculosis drug (rifampicin), antibiotics (clarithromycin, erythromycin), antifungals (itraconazole, fluconazole, griseofulvin), cardiac medications(verapamil, diltiazem) and anti-retroviral drugs (ritonavir, nelfinavir, nevirapine)

Drug-Food Interactions: Grapefruit juice may interfere with the absorption of Estofol 2 mg Tablet . Proceed with caution.

Drug-Disease Interactions: Inform your doctor if you have/had breast cancer, cervical cancer, stroke, epilepsy, porphyria, thrombosis, pulmonary embolism, cardiovascular disturbances, gallstones, migraine or any severe headaches, anaemias, bleeding disorders, liver problem, kidney problem, depression, and any other hormone-dependent cancers.

Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • ITRACONAZOLE
  • FLUCONAZOLE
  • GRISEOFULVIN
  • VERAMAPIL
  • RITONAVIR
  • NELFINAVIR
  • NEVIRAPINE
  • DILTIAZEM

Habit Forming

No

Diet & Lifestyle Advise

  • As nausea and vomiting may occur with the use of Estofol 2 mg Tablet , make sure to take it on light, small meals. 
  • Avoid grapefruit juice while taking Estofol 2 mg Tablet as this may interact with Estofol 2 mg Tablet and affect its absorption. 
  • Avoid smoking as it increases the risk of stroke. 
  • Keep your meals balanced and invest in a healthy diet to avoid any cardiovascular problems. 
  • Load up on meats, fatty fish, oranges and strawberries, sesame seeds, soybean and canola oil and pistachios to enhance anti-oxidation and overall health during menopause.

Special Advise

  • Your doctor may recommend regular breast examinations/screenings and routine cervical smears while you are on Estofol 2 mg Tablet , just to be on the safe side. Be sure to attend the check-ups.
  • Regularly check your breasts at home in front of a mirror, for any changes such as skin dimpling, nipple discharge, or any lumps.  
  • Inform the doctor immediately if you notice any breast lump, dark urine, yellowing of the skin, mood changes, headache, palpitations, severe fatigue or any alarming changes in vaginal bleeding. 
  • Call for the doctor right away in case of any stroke symptoms such as breathlessness, confusion, dizziness, left arm pain, jaw pain or sudden vision changes and pulmonary embolism symptoms such as cough, leg pain and warmth, pain in calf etc.

Disease/Condition Glossary

Post-Menopausal Syndrome: Menopause is the ceasing of a woman’s menstrual cycle around the age of 45-51. It is marked by an absence of periods for a consecutive time of at least 12 months. It is characterised by hot flashes, mood changes, decreased libido, changes in the skin, vaginal dryness and osteoporosis.  

Osteoporosis: It is a bone disease that weakens and thins the bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, women's ovaries stop producing oestrogen (a female hormone) that is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more easily than expected.

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Alcohol

Caution

Caution should be exercised while consuming alcohol with Estofol 2 mg Tablet as there may be an interaction.

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Pregnancy

Unsafe

Estofol 2 mg Tablet is indicated for use only in menopausal conditions and is not recommended for use during pregnancy.

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Breast Feeding

Unsafe

Estofol 2 mg Tablet is indicated for use only in menopausal conditions and is not recommended for use during breastfeeding.

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Driving

Safe if prescribed

Estofol 2 mg Tablet does not normally affect your ability to drive.

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Liver

Caution

Take Estofol 2 mg Tablet with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Estofol 2 mg Tablet should be used with caution in patients suffering from kidney disease. Please consult your doctor in case of any concerns.

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Children

Unsafe

Estofol 2 mg Tablet is not meant for use by children or adolescents.

Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - EST0204

FAQs

Estofol 2 mg Tablet is a hormone replacement therapy used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate.
Estofol 2 mg Tablet works by enhancing the levels of the sex hormone oestrogen in the female body. Thereby, helps treat menopausal symptoms.
Yes, Estofol 2 mg Tablet is very effective in combating hot flashes in menopausal women.
Estofol 2 mg Tablet helps with various symptoms of menopause including osteoporosis and weakened bones. However, you may need Vitamin D supplements to address this issue. Discuss with your physician.
You may be advised to stop taking Estofol 2 mg Tablet about 4 to 6 weeks before surgery to decrease the risk of a blood clot. Therefore, inform your doctor that you are taking Estofol 2 mg Tablet before undergoing any surgery.
Estofol 2 mg Tablet is not a contraceptive. Estofol 2 mg Tablet is a hormone replacement therapy. Therefore, if you are less than 50 years old or if it is less than 12 months since your last period, you are advised to use additional contraceptive measures to avoid pregnancy. However, discuss with a doctor if you have any concerns regarding this.
Estofol 2 mg Tablet comprises the active ingredient Estradiol valerate, which is used as a hormone therapy for menopausal symptoms and hypoestrogenism (low estrogen levels).
If you miss a dose of Estofol 2 mg Tablet , take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and take your next dose at the usual time. Do not take two doses at once to make up for a missed dose. Always follow your doctor's instructions for dosing.
Estofol 2 mg Tablet may cause common side effects such as nausea, vomiting, breast soreness, headache, and bloating. Most of these side effects do not require medical attention and will resolve on their own over time. However, please consult your doctor if these side effects persist or become bothersome.
For estrogen deficiency, treatments may include hormone replacement therapy (HRT), such as Estofol 2 mg Tablet , which can be prescribed by your doctor. Other options include non-hormonal medications, lifestyle changes, and dietary adjustments. It is important to consult with your doctor to determine the most suitable treatment based on your specific health condition.
Estofol 2 mg Tablet should not be taken by individuals who are allergic to any of its ingredients. It is also not recommended for people with a history of certain health conditions, such as breast cancer, abnormal genital bleeding, blood clots, stroke, myocardial infarction, or liver disease. Always consult your doctor before starting this medication to ensure it is safe for you. Estofol 2 mg Tablet is intended for use in postmenopausal women and should not be taken if you are pregnant or breastfeeding.
Estofol 2 mg Tablet , a form of estrogen used in hormone therapy, may cause weight changes in some individuals, but weight gain is not a guaranteed side effect. If you notice significant changes in your weight, please consult your doctor.
Estofol 2 mg Tablet should be taken exactly as directed by your doctor. It is usually taken orally, with or without food, at the same time each day. Swallow the medication as a whole with a glass of water. Do not crush, chew, or break it.

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