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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Esiflo 125 Transhaler is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). It contains Salmeterol and Fluticasone, which relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Also, it acts by blocking the production of prostaglandins (chemical messengers) that cause inflammation (swelling) of the airways. It may cause common side effects such as nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

INHALATION

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Esiflo 125 Transhaler

Esiflo 125 Transhaler is a respiratory medication used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Asthma is a breathing problem in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes).

Esiflo 125 Transhaler is a combination of two medicines: Salmeterol (bronchodilator) and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Your doctor will advise on how often you take Esiflo 125 Transhaler based on your medical condition. The common side effects of Esiflo 125 Transhaler include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Most of these side effects of Esiflo 125 Transhaler do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Brief your medical history to the doctor if you have heart, liver, kidney diseases, hypokalaemia (low potassium levels in the blood), hyperadrenocorticism (high levels of cortisol), eye disorders like cataract and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes before taking Esiflo 125 Transhaler. Therapy with nasal or inhaled corticosteroids like Fluticasone should be cautiously administered in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since there are chances of developing a secondary infection. Please check with your doctor if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines.

Uses of Esiflo 125 Transhaler

Treatment of Chronic Obstructive Pulmonary Disease (COPD), Bronchitis, Asthma, and Emphysema.

Directions for Use

Inhaler: Hold the inhaler with the mouthpiece facing downwards. Form a tight seal by placing your lips around the mouthpiece. Start breathing slowly with your mouth and push down the inhaler once. Remove the inhaler and breathe normally.Rotacap/Transcap:Rotacap/Transcap is a capsule with powdered medication which is placed in Rotahaler. It is for inhalation only. Do not swallow the capsule. Rotahaler/Transhaler is a plastic inhalation device that releases the medication when you breathe. The capsule should be placed at the base of the rotahaler/transhaler and completely twist the mouthpiece until you hear a click sound. Then, breathe in through the mouthpiece deeply and hold your breath for 10 seconds. Remove the device and breathe out normally.Respicap/Instacaps: Please read the instruction leaflet before usage and use in the dose and duration suggested by your doctor.Autohaler: Autohaler is a breath-activated device that releases the medication when you inhale. Shake the autohaler well before using it. Hold it upright and push the lever up. Place the mouthpiece in your mouth and seal your lips around it. Breathe in slowly and deeply to release the medication from the device. Hold your breath for 10 seconds and breathe out normally. Push the lever down and replace the cap.Inhalation Capsule: The capsule is meant for inhalation only; do not swallow the capsule. Check the instructions leaflet before use. Place it at the base of the inhaler and twist the mouthpiece until you hear a click sound. Breathe deeply through the mouthpiece and hold your breath for 10 seconds.Oral inhalation (Powder): Check the label for directions to use. Inhale the powder by mouth using an inhaler.Rotadisk: Rotadisk is a silver-coloured aluminium foil disk that contains four blisters to place the medication. The medicine is to be inhaled through the mouth from the Rotadisk using a plastic device called Diskhaler.

Medicinal Benefits

Esiflo 125 Transhaler is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Esiflo 125 Transhaler improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). Esiflo 125 Transhaler is a combination of Salmeterol (bronchodilator) and Fluticasone (corticosteroid). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

How Esiflo 125 Transhaler Works

Esiflo 125 Transhaler is a combination of two medicines: Salmeterol (bronchodilator) and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Esiflo 125 Transhaler

  • Nausea
  • Vomiting
  • Respiratory tract infection
  • Headache
  • Sore throat
  • Cough
  • Bone, muscle or joint pain
  • Increased heart rate
  • Chills
  • Black or tarry stools
  • Noisy breathing

What if I have taken an overdose of Esiflo 125 Transhaler

Do not use Esiflo 125 Transhaler in more doses or more often than prescribed as it may cause overdose. The symptoms of overdose include chest pain, dry mouth, confusion, decreased urine output, loss of appetite, high blood pressure, nervousness or mood changes. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not stop taking this medicine of your own unless advised by your doctor. Before taking Esiflo 125 Transhaler, let your doctor know if have a history of heart, liver, kidney diseases, hyperadrenocorticism (high levels of cortisol), eye disorders like cataracts and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes. Esiflo 125 Transhaler causes hypokalemia (low potassium levels in the blood), therefore should be used with caution in patients with hypokalaemia to prevent any cardiovascular effects.  Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. Esiflo 125 Transhaler can cause a rise in blood glucose levels. Hence monitor your blood glucose levels regularly if you are diabetic. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using Esiflo 125 Transhaler. Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
SalmeterolFosamprenavir
Severe

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
How does the drug interact with Esiflo 125 Transhaler:
Co-administration of Esiflo 125 Transhaler with Mifepristone may make Esiflo 125 Transhaler less effective as a therapy.

How to manage the interaction:
Taking Esiflo 125 Transhaler with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
SalmeterolFosamprenavir
Severe
How does the drug interact with Esiflo 125 Transhaler:
The combined use of Fosamprenavir and Esiflo 125 Transhaler can increase the risk of irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Esiflo 125 Transhaler and Fosamprenavir, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
SalmeterolNelfinavir
Severe
How does the drug interact with Esiflo 125 Transhaler:
Nelfinavir may significantly increase the blood levels of Esiflo 125 Transhaler. High blood levels of Esiflo 125 Transhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Esiflo 125 Transhaler with Nelfinavir can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolCocaine
Severe
How does the drug interact with Esiflo 125 Transhaler:
Using Esiflo 125 Transhaler together with cocaine nasal may occasionally cause irregular heart rhythm.

How to manage the interaction:
Co-administration of Esiflo 125 Transhaler with Cocaine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
SalmeterolCarvedilol
Severe
How does the drug interact with Esiflo 125 Transhaler:
Taking Carvedilol and Esiflo 125 Transhaler may reduce the effects of both medications.

How to manage the interaction:
There may be a possibility of interaction between Esiflo 125 Transhaler and Carvedilol, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
SalmeterolVoriconazole
Severe
How does the drug interact with Esiflo 125 Transhaler:
Taking Voriconazole may significantly increase the blood levels of Esiflo 125 Transhaler. High blood levels of Esiflo 125 Transhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Voriconazole and Esiflo 125 Transhaler together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, shortness of breath, or heart palpitations (irregular heartbeat), contact a doctor right away. Do not discontinue any medications without consulting a doctor.
SalmeterolIdelalisib
Severe
How does the drug interact with Esiflo 125 Transhaler:
The combined use of Idelalisib and Esiflo 125 Transhaler can increase the risk of irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Esiflo 125 Transhaler and Idelalisib, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolClarithromycin
Severe
How does the drug interact with Esiflo 125 Transhaler:
Taking Clarithromycin may boost the blood levels of Esiflo 125 Transhaler increasing the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Esiflo 125 Transhaler if prescribed by the doctor. Consult the prescriber if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. Do not stop using any medications without a doctor's advice.
SalmeterolTelithromycin
Severe
How does the drug interact with Esiflo 125 Transhaler:
Telithromycin may significantly increase the blood levels of Esiflo 125 Transhaler. High blood levels of Esiflo 125 Transhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Esiflo 125 Transhaler and Telithromycin, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolTelaprevir
Severe
How does the drug interact with Esiflo 125 Transhaler:
Co-administration of Telaprevir and Esiflo 125 Transhaler can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Esiflo 125 Transhaler with Telaprevir together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Esiflo 125 Transhaler.

  • Know your triggers like allergens, such as pollen, dust, and food items that make your asthma severe.

  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.

  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.

  • Learning breathing exercises will help you move more air in and out of your lungs.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Esiflo 125 Transhaler Substitute

Substitutes safety advice
  • Flutrol 125 Inhaler 120 mdi

    4.19per tablet
  • Combitide 25/125 mcg Starhaler Inhaler 120 mdi

    4.09per tablet
  • Seretide 125 Evohaler 120 MDI

    32.48per tablet
  • SEROFLO 125MG AUTO HALER

    777.60per tablet
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Alcohol

Caution

Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

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Pregnancy

Caution

Please consult your doctor if you are planning to conceive or are already pregnant before starting Esiflo 125 Transhaler.

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Breast Feeding

Caution

There is limited data on how Esiflo 125 Transhaler affects breastfeeding. Please consult your doctor before starting Esiflo 125 Transhaler.

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using Esiflo 125 Transhaler. This may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Esiflo 125 Transhaler should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Esiflo 125 Transhaler.

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Kidney

Caution

Esiflo 125 Transhaler should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Esiflo 125 Transhaler.

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Children

Caution

Esiflo 125 Transhaler is not recommended for use for children less than four years of age. The dose may have to be adjusted by your doctor depending upon the condition of the child's disease and age.

FAQs

Esiflo 125 Transhaler is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD).
Esiflo 125 Transhaler is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Esiflo 125 Transhaler consists of Salmeterol (bronchodilator) and Fluticasone (Fluticasone). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.
Esiflo 125 Transhaler should be cautiously administered under the doctor's guidance in seizures since bronchodilators like Salmeterol can cause central nervous system stimulation that can lead to other adverse conditions. Please consult your doctor before using Esiflo 125 Transhaler if you have seizures.
Esiflo 125 Transhaler contains bronchodilator (Fluticasone), which can cause a rise in blood glucose levels. Hence therapy with Esiflo 125 Transhaler is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so that the dose can be adjusted accordingly.
Bronchodilator (Salmeterol) in Esiflo 125 Transhaler may decrease the potassium levels in your body, therefore should be used with caution. Please consult your doctor before taking Esiflo 125 Transhaler since low potassium levels can lead to other cardiovascular problems in patients with hypokalaemia.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info - ESI0002

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