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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:48 PM IST
EPOTRUST 2000IU INJECTION 1ML is used to treat anaemia in cancer, chronic kidney disease, and HIV. It contains Epoetin alfa which works by stimulating the bone marrow to make more red blood cells. In some cases, this medicine may cause side effects such as diarrhoea, vomiting, fever, feeling sick, stuffy nose and sore throat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Panacea Biotec Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About EPOTRUST 2000IU INJECTION 1ML

EPOTRUST 2000IU INJECTION 1ML belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in persons with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells' cancer). Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

EPOTRUST 2000IU INJECTION 1ML contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). EPOTRUST 2000IU INJECTION 1ML helps to reverse anaemia and reduce the need for blood transfusion. EPOTRUST 2000IU INJECTION 1ML is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, EPOTRUST 2000IU INJECTION 1ML stimulates the production of this protein in the bone marrow. 

EPOTRUST 2000IU INJECTION 1ML will be administered by a healthcare professional; do not self-administer. The most common side effects of EPOTRUST 2000IU INJECTION 1ML are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these side effects of EPOTRUST 2000IU INJECTION 1ML do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to epoetin alfa or darbepoetin alfa, please inform your doctor before taking EPOTRUST 2000IU INJECTION 1ML to avoid any complications. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be a sign that the body has stopped responding to EPOTRUST 2000IU INJECTION 1ML. It is not known whether EPOTRUST 2000IU INJECTION 1ML will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant and breastfeeding before starting treatment with this medicine. EPOTRUST 2000IU INJECTION 1ML is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might be lost. Do not store in the freezer or the fridge.

Uses of EPOTRUST 2000IU INJECTION 1ML

Treatment of Anemia in cancer, Anemia in chronic kidney disease, Anemia in HIV.

Medicinal Benefits

EPOTRUST 2000IU INJECTION 1ML is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn causes low red blood cells count causing anemia.  This medicine is primarily indicated for treating anemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease, persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells cancer, and persons taking zidovudine to treat HIV(human immunodeficiency virus). EPOTRUST 2000IU INJECTION 1ML is also used to reduce the need for red blood cell transfusions in adults having certain types of surgery. EPOTRUST 2000IU INJECTION 1ML contains a protein 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

Directions for Use

EPOTRUST 2000IU INJECTION 1ML will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of EPOTRUST 2000IU INJECTION 1ML

  • Shortness of breath Cough
  • Hypertension (high blood pressure)
  • High blood sugar
  • Headache
  • Body aches
  • Diarrhoea
  • Injection site pain 
  • Abdominal pain (stomach pain) 

Drug Warnings

EPOTRUST 2000IU INJECTION 1ML can enhance the risk of blood clots and serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may speed up tumor growth, or shorten remission or survival time in some people with certain types of cancer. Inform your doctor before taking EPOTRUST 2000IU INJECTION 1ML if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take EPOTRUST 2000IU INJECTION 1ML if you are pregnant or breastfeeding unless prescribed by the doctor. EPOTRUST 2000IU INJECTION 1ML should not be given to children below 1 month of age, as safety and effectiveness have not been established. Do not use EPOTRUST 2000IU INJECTION 1ML from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient (benzyl alcohol) that can cause serious side effects or death in very young infants or premature babies. EPOTRUST 2000IU INJECTION 1ML may affect a person's ability to drive as it may cause convulsions during the initial days of treatment, so a person taking EPOTRUST 2000IU INJECTION 1ML should avoid driving or operating any machine. Avoid consuming alcohol along with EPOTRUST 2000IU INJECTION 1ML as it could lead to increased dizziness and sleepiness. 

Drug Interactions

Drug-Drug Interactions: EPOTRUST 2000IU INJECTION 1ML may have interaction with other chemotherapy drugs (thalidomide, carfilzomib, lenalidomide, pomalidomide),  immunosuppressant medication (cyclosporine),  antihypertensive medicines (captopril, benazepril, enalapril, lisinopril, moexipril). 

Drug-Food Interactions: Avoid alcohol consumption while taking EPOTRUST 2000IU INJECTION 1ML as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: EPOTRUST 2000IU INJECTION 1ML may have interactions with disease conditions such as seizures, hemodialysis, hypertension, porphyria (liver disorders) and thrombotic events.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • LENALIDOMIDE
  • CYCLOSPORINE
  • CAPTOPRIL
  • ENALAPRIL
  • LISINOPRIL
  • CARFILZOMIB
  • POMALIDOMIDE
  • MOEXIPRIL

Habit Forming

No

Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfill the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that gives you enough energy to be active during the day; however, try to limit fats that make you fat. Try to include olive oil, peanut oil, and corn oil in your diet.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Special Advise

  • Certain diagnostic tests like Complete blood count (CBC) can help check the count of red blood cells.
  • Have regular hemoglobin tests to check whether there is an improvement in the level of red blood cells after taking EPOTRUST 2000IU INJECTION 1ML or not.
  • You should not use EPOTRUST 2000IU INJECTION 1ML if you have uncontrolled high blood pressure (hypertension), or if you have ever had pure red cell aplasia (PRCA, a type of anemia) caused by using EPOTRUST 2000IU INJECTION 1ML. 
  • Call your doctor at once if you experience any sign of a blood clot, sudden numbness or weakness, blur vision, speech problem, chest pain, trouble breathing, pain or cold feeling in leg or arm. 
  • Discard any leftover medicine in a multi-dose vial of EPOTRUST 2000IU INJECTION 1ML 21 days after the first use.

Disease/Condition Glossary

Anaemia: It occurs when the body has a lower amount of red blood cells or haemoglobin than normal haemoglobin (iron-rich protein responsible for allowing red blood cells to carry more oxygen from the lungs to the rest of the body).  In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia. Symptoms of anaemia in chronic kidney disease include fatigue or tiredness, shortness of breath, ashen skin, weakness, body aches, chest pain, dizziness, fainting, fast or irregular heartbeat, headache, sleep problems, and trouble concentrating. 

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Alcohol

Unsafe

Avoid consumption of alcohol while taking EPOTRUST 2000IU INJECTION 1ML as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking EPOTRUST 2000IU INJECTION 1ML if you are pregnant unless prescribed by a doctor as EPOTRUST 2000IU INJECTION 1ML is a pregnancy category B drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. If prescribed use only single-dose vials (the benzyl alcohol-free formulation) in pregnant women.

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Breast Feeding

Caution

Consult your doctor before taking EPOTRUST 2000IU INJECTION 1ML; your doctor will decide whether EPOTRUST 2000IU INJECTION 1ML can be taken by breastfeeding mothers or not.

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Driving

Caution

EPOTRUST 2000IU INJECTION 1ML causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

EPOTRUST 2000IU INJECTION 1ML should not be given to neonates as the safety and efficacy have not been established.

Country of origin

India

Manufacturer/Marketer address

Ambala- Chandigarh Highway, Lalru – 140501, Punjab
Other Info - EPO0020

Author Details

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FAQs

EPOTRUST 2000IU INJECTION 1ML is used to treat anaemia (low red blood cell count) in people with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells cancer).
EPOTRUST 2000IU INJECTION 1ML contains a protein "Epoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.
A person who is allergic to any chemical compound present in EPOTRUST 2000IU INJECTION 1ML or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.
It is suggested to store the EPOTRUST 2000IU INJECTION 1ML in the refrigerator between 2 and 8 ℃ and protect it from light. However, a person should not freeze it.
The common side-effects of EPOTRUST 2000IU INJECTION 1ML are headache and pain, redness at the injection site. These side-effects are usually mild and temporary. However, inform your doctor immediately if any of these side-effects persist or get worse.
EPOTRUST 2000IU INJECTION 1ML will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse based on individual considerations.
Since EPOTRUST 2000IU INJECTION 1ML will be administered by the doctor it is unlikely to exceed the recommended dose. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.
Yes, EPOTRUST 2000IU INJECTION 1ML will be given to children by the doctor if needed. However, it should not be given to children under 1 month of age, as its safety and effectiveness have not been established for this age group. Consult the doctor if you have any concerns.
Yes, EPOTRUST 2000IU INJECTION 1ML may cause hypertension (high blood pressure). The doctor will control high blood pressure before and during treatment. However, it is not recommended for people with uncontrolled hypertension. Let the doctor know if you have hypertension before starting treatment with EPOTRUST 2000IU INJECTION 1ML.

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Keep Refrigerated. Do not freeze.