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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Eplebless 25 Tablet is used to treat hypertension (high blood pressure). It also maintains the bloodstream's potassium level, removes excess water from the body, and prevents hypertension (high blood pressure) due to oedema (fluid retention). It contains Eplerenone, which works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and the heart's workload, making it more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid.

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Composition :

EPLERENONE-25MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Eplebless 25 Tablet

Eplebless 25 Tablet is used to treat hypertension (high blood pressure). It also maintains the bloodstream's potassium level, removes excess water from the body, and prevents hypertension (high blood pressure) due to oedema (fluid retention). Blood pressure measures the force our heart uses to pump blood to all body parts. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.

Eplebless 25 Tablet contains Eplerenone, which is prescribed for the treatment of hypertension. Eplebless 25 Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and the heart's workload, making it more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain).

Take Eplebless 25 Tablet as prescribed by your doctor. Depending upon your medical condition, you are advised to take Eplebless 25 Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. Most of these side effects of Eplebless 25 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Eplebless 25 Tablet of your own, as doing so may raise your blood pressure, thereby increasing the risk of heart disease and stroke. Inform your doctor if you have any kidney disease (with creatinine clearance less than 30 mL/min), liver disease, high serum potassium (hyperkalemia), diabetes mellitus type 2, and patients with nil urine output (anuria). If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Eplebless 25 Tablet can be prescribed accordingly. Please tell your doctor if you are taking any other medicines or are allergic to the Eplebless 25 Tablet . Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Please take Eplebless 25 Tablet at least 4 hours before sleeping to avoid frequent urination at night. Also, do not take Eplebless 25 Tablet along with lithium to prevent serious side effects.

Uses of Eplebless 25 Tablet

Treatment of Hypertension (high blood pressure) and oedema.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Eplebless 25 Tablet  primarily used to treat hypertension (high blood pressure) and heart failure. It also treats edema (reduces swelling) caused due to other conditions. Eplebless 25 Tablet works by increasing the amount of urine passing from the kidneys. It effectively reduces excess fluid levels in the body, reduces the heart's workload, and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future.

How Eplebless 25 Tablet Works

Eplebless 25 Tablet contains Eplerenone, which is prescribed for the treatment of hypertension. Eplebless 25 Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and the heart's workload, making it more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Eplebless 25 Tablet

  • Dizziness
  • Nausea
  • Dizziness
  • Headache
  • Cough
  • Increased creatinine and potassium in the blood
  • Fatigue

What if I have taken an overdose of Eplebless 25 Tablet

Do not take more than the prescribed dose of Eplebless 25 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Eplebless 25 Tablet should not be given to the people allergic to Eplebless 25 Tablet , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, high serum potassium (hyperkalemia), diabetes mellitus type 2 and patients with nil urine output (anuria), pregnant women, planning to get pregnant and breastfeeding women. Eplebless 25 Tablet can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you are taking Eplebless 25 Tablet and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using Eplebless 25 Tablet . Do not take extra potassium supplements or potassium-rich foods such as bananas and broccoli with Eplebless 25 Tablet . It may lead to an excessive increase in blood potassium levels (hyperkalemia). Please take Eplebless 25 Tablet at least 4 hours before sleeping to avoid frequent urination at night. Also, do not take Eplebless 25 Tablet along with lithium to prevent serious side effects.

Drug-Drug Interactions

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EplerenonePotassium chloride
Critical
EplerenoneItraconazole
Critical

Drug-Drug Interactions

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EplerenonePotassium chloride
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Using Eplebless 25 Tablet 10's together with Potassium chloride may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking potassium chloride with Eplebless 25 Tablet 10's is not recommended. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult the doctor immediately. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
The blood levels and effects of Eplebless 25 Tablet 10's may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Eplebless 25 Tablet 10's and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
EplerenoneNefazodone
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Coadministration of Nefazodone with Eplebless 25 Tablet 10's can increase the levels of Eplebless 25 Tablet 10's in the body.

How to manage the interaction:
Taking Nefazodone with Eplebless 25 Tablet 10's together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenonePotassium citrate
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Taking Eplebless 25 Tablet 10's with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Eplebless 25 Tablet 10's, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneKetoconazole
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Coadministration of Ketoconazole with Eplebless 25 Tablet 10's can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Eplebless 25 Tablet 10's is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenoneSpironolactone
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Combining Eplebless 25 Tablet 10's with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Eplebless 25 Tablet 10's, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Co-administration of Eplebless 25 Tablet 10's and Ritonavir may significantly increase the blood levels of Eplebless 25 Tablet 10's.

How to manage the interaction:
Taking Ritonavir and Eplebless 25 Tablet 10's together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneClarithromycin
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Co-administration of Eplebless 25 Tablet 10's and Clarithromycin may significantly increase the blood levels and effects of Eplebless 25 Tablet 10's.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Eplebless 25 Tablet 10's is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Combining Eplebless 25 Tablet 10's with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Eplebless 25 Tablet 10's, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Eplebless 25 Tablet 10's:
Coadministration of posaconazole with Eplebless 25 Tablet 10's can increase the blood levels of Eplebless 25 Tablet 10's. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Eplebless 25 Tablet 10's, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are highly antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise like walking improves your blood flow.
  • Elevate your legs or the swollen area on a chair or pillow.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

DIURETIC

Eplebless 25 Tablet Substitute

Substitutes safety advice
  • Eptus 25 Tablet 15's

    39.54per tablet
  • Planep 25 mg Tablet 15's

    by AYUR

    29.01per tablet
  • Eplehef 25 Tablet 10's

    by AYUR

    21.60per tablet
  • Epnone 25 Tablet 10's

    by AYUR

    23.49per tablet
  • Eplerite 25 Tablet 10's

    17.82per tablet
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Eplebless 25 Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Eplebless 25 Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Breast-feeding must be avoided during treatment with Eplebless 25 Tablet . It is only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Unsafe

It is not recommended to drive after taking Eplebless 25 Tablet as it may occasionally cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position).

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Liver

Caution

Inform your doctor before receiving the Eplebless 25 Tablet if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Kidney

Caution

Inform your doctor before receiving the Eplebless 25 Tablet if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Caution

Eplebless 25 Tablet is not recommended for children below 12 years of age.

FAQs

Eplebless 25 Tablet is used to treat hypertension (high blood pressure) and oedema.
Eplebless 25 Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future.
It is not common, but Eplebless 25 Tablet can sometimes increase blood sugar levels. Therefore, it is crucial to monitor your blood sugar level to check for any fluctuations. Also, the use of Eplebless 25 Tablet should be avoided in patients with type 2 diabetes and some kidney problems.
Yes, Eplebless 25 Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Eplebless 25 Tablet . Please monitor your electrolyte level regularly to avoid increased blood potassium levels.
It is a medical term for fluid retention or overload. Due to oedema, the legs, hands, and other body parts start swelling, increasing blood pressure. If it does not subside, please consult your doctor immediately.
The main side effect of Eplebless 25 Tablet is peeing (urination) more often than normal. Most people need to pee about 30 minutes after taking Eplebless 25 Tablet and again within a few hours. Do not take Eplebless 25 Tablet before going to bed, or you may have to wake up at night to go for urination frequently.
No, it is not recommended to take Eplebless 25 Tablet along with lithium. It might increase lithium's level in the blood and lead to unpleasant side effects like visual impairment, loss of appetite, and muscle weakness. So, inform your doctor before starting Eplebless 25 Tablet if you take lithium is recommended.
No, Eplebless 25 Tablet is not a blood thinner. It is a diuretic used to treat high blood pressure and swelling.
Eplebless 25 Tablet contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.
Eplebless 25 Tablet may take up to 4 weeks to show its full effect. Keep taking Eplebless 25 Tablet for the prescribed duration.
No, Eplebless 25 Tablet is not known to cause erectile dysfunction. It does not have any effect on fertility.
Do not discontinue Eplebless 25 Tablet without consulting the doctor. To treat your condition effectively, keep taking Eplebless 25 Tablet for the prescribed duration.
Potassium-sparing diuretics increase urine production without depleting potassium reserves. Eplebless 25 Tablet permits the body to lose sodium while retaining potassium. The amounts of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.
Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Eplebless 25 Tablet along with hydrochlorothiazide to prevent the rise in potassium levels.
Before starting Eplebless 25 Tablet , let the doctor know if you are taking aspirin. Taking aspirin with Eplebless 25 Tablet may decrease the effects of Eplebless 25 Tablet . Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.
Side effects of Eplebless 25 Tablet include dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. If the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Other Info - EPL0015

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