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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:30 PM IST

Epival Syrup is used to treat epilepsy/seizures/fits and bipolar disorder. It contains 'Sodium valproate', which decreases the brain's excessive and abnormal nerve activity. Thus, it helps in controlling seizures. On the other hand, it increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thus, it helps treat bipolar disorder.

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Synonym

VALPROIC ACID

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Epival Syrup

Epival Syrup is used to treat epilepsy/seizures/fits and bipolar disorder. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 

Epival Syrup contains 'Sodium valproate', which decreases the brain's excessive and abnormal nerve activity. Thus, it helps in controlling seizures. Epival Syrup increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thus, it helps treat bipolar disorder. 

Use Epival Syrup as prescribed by your doctor. Sometimes, it may cause certain side effects such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually. However, if the side effects persist or worsen, inform your doctor immediately.

Before using Epival Syrup , inform your doctor about your children's medical conditions, sensitivities, and all medications used. To treat your condition effectually, continue using Epival Syrup for as long as your doctor has prescribed. Epival Syrup should be gradually withdrawn, so please do not stop using Epival Syrup without consulting your doctor. Consult your doctor immediately if you observe any suicidal tendencies in your children.

Uses of Epival Syrup

Treatment of Epilepsy and Bipolar disorder

Medicinal Benefits

Sodium valproate reduces the brain's excessive and unusual nerve activity. On the other hand, it helps to raise the quantity of a chemical substance called GABA in the brain, which helps to stop nerve transmission and has a calming effect. Thus, it aids in the treatment of epilepsy, seizures, and fits, as well as bipolar disorder.

Directions for Use

Give this medicine to your child as directed by your physician or per instructions in the package leaflet.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Epival Syrup

  • Feeling or being sick
  • Feeling tired or sleepy
  • Stomach pain
  • Diarrhoea
  • Dry or sore mouth
  • Swollen gums
  • Shakes (tremors) in a part of your body
  • Unusual eye movements
  • Headache
  • Weight gain

Drug Warnings

The presence of other medical problems or using other medications may affect the use of this medicine. So, before using Epival Syrup , let your doctor know about all your children's medical conditions, sensitivities, and all medications used. Do not use this medication on your own unless prescribed by the doctor. Do not exceed the stated recommended dose.

Drug Interactions

Drug-Drug Interactions: Epival Syrup may have interaction with pain killers (aspirin), anti-epileptics (phenobarbital, primidone, phenytoin, carbamazepine, topiramate, acetazolamide, lamotrigine, felbamate), blood thinner (warfarin), anti-HIV (zidovudine, lopinavir, ritonavir), anti-depressant (moclobemide, selegiline, linezolid, amitriptyline, sertraline), anti-psychotic (quetiapine, olanzapine, risperidone), calcium channel blocker (nimodipine), anaesthetic (propofol), hormone (oestrogen, levonorgestrel), anti-malarial (mefloquine, chloroquine), antacid (cimetidine), antibiotics (imipenem, meropenem, rifampicin, erythromycin), bile-acid sequestrant (cholestyramine), benzodiazepine (clonazepam, diazepam).

Drug-Food Interactions: Epival Syrup may interact with alcoholic beverages. 

Drug-Disease Interactions: Epival Syrup may interact with disease conditions, including depression, liver disease, urea cycle disorders, suicidal tendencies, HIV/CMV and thrombocytopenia.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • TOPIRAMATE
  • ACETAZOLAMIDE
  • LAMOTRIGINE
  • FELBAMATE
  • WARFARIN
  • ZIDOVUDINE
  • LOPINAVIR
  • RITONAVIR
  • MOCLOBEMIDE
  • SELEGILINE
  • LINEZOLID
  • AMITRIPTYLINE
  • SERTRALINE
  • QUETIAPINE
  • OLANZAPINE
  • RISPERIDONE
  • NIMODIPINE
  • PROPOFOL
  • OESTROGEN
  • LEVONORGESTREL
  • MEFLOQUINE
  • CHLOROQUINE
  • CIMETIDINE
  • IMIPENEM
  • MEROPENEM
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CHOLESTYRAMINE
  • CLONAZEPAM
  • DIAZEPAM

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps utilise fat instead of glucose for energy generation.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your children's living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures are and try reducing or avoiding them.
  • Install an alarm or emergency device to get assistance during a seizure attack.
  • Let your child rest well and sleep well.

Special Advise

Maintain all scheduled follow-up appointments with your healthcare practitioner.

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a nervous system disorder that occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows.

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Alcohol

Not applicable

It is intended for Children.

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Pregnancy

Not applicable

It is intended for Children.

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Breast Feeding

Not applicable

It is intended for Children.

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Driving

Not applicable

It is intended for Children.

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Liver

Caution

Inform your doctor if your child has liver problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor if your child has kidney problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Epival Syrup can be given safely to children. Give this medicine to your child in the doses as prescribed by the doctor.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - EPI0011

Author Details

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FAQs

Epival Syrup is used to treat epilepsy/seizures/fits and bipolar disorder.
Epival Syrup decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Epival Syrup helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Do not discontinue Epival Syrup without consulting your doctor. To treat your child's condition effectually, continue using Epival Syrup for as long as prescribed. Do not be reluctant to speak with your doctor if your child experiences difficulty while taking Epival Syrup ; your doctor will gradually reduce the dose to avoid worsening seizures.
Epival Syrup may change the results of liver enzymes and urine and blood tests. Inform the person doing the tests that your child using Epival Syrup .

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