EPALRICA MP TABLET belongs to the class of medications called ‘antidiabetics’ used in treating diabetic neuropathy. Diabetic neuropathy is a chronic progressive nerve disease that causes nerve pain due to nerve damage in diabetic patients. It is a complication seen in diabetic patients (especially those with untreated or uncontrolled diabetes). It mostly affects the legs and feet.

EPALRICA MP TABLET contains Epalrestat, Methylcobalamin, and Pregabalin. Epalrestat is an aldose reductase inhibitor. The inhibition of aldose reductase (an enzyme) can reduce levels of sorbitol, which causes nerve damage. It doesn’t show any effect on glucose levels. Methylcobalamin is vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (the protective layer of nerve cells). Pregabalin is an anticonvulsant that affects the chemicals in the brain that send pain signals across the nervous system.

You should take this medicine exactly as prescribed by the doctor. The common side effects of EPALRICA MP TABLET are nausea, vomiting, dizziness, drowsiness, headache, diarrhoea, dry mouth, blurred vision, increased appetite, trouble concentrating, and swelling in the hands and feet. These side effects usually resolve without requiring any treatment. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take EPALRICA MP TABLET if you are allergic to any contents of it. It should not be used in patients with severe liver disease. Before taking EPALRICA MP TABLET, inform your doctor if you have mood disorders, lung problems, heart problems, bleeding disorders, kidney disease, drug or alcohol abuse, and angioedema (a severe allergic reaction). It is not approved for use in children and adolescents under 18 years of age. It should be used with caution in pregnant women, breastfeeding mothers, and elderly people. Do not consume alcohol while taking this medicine. EPALRICA MP TABLET may decrease alertness and vision, so do not drive or operate heavy machinery if you are not fully alert.

EPALRICA MP TABLET is used in the treatment of diabetic neuropathy, which is a complication seen in patients with diabetes. It can effectively reduce pain by reducing nerve damage. It can slow down the progression of the disease. It can also improve other symptoms, such as difficulty sleeping and tiredness. It can help you to perform daily activities normally, thereby improving your quality of life. Adherence to anti-diabetic medicines is necessary to control disease and get the overall benefits of this medicine.

• Nausea
• Vomiting
• Dizziness
• Drowsiness
• Headache
• Diarrhoea
• Dry mouth
• Blurred vision
• Increase in appetite
• Trouble concentrating
• Swelling in the hands and feet

EPALRICA MP TABLET should be used with caution in patients with heart problems, as it may cause weight gain and swelling in the hands and feet. EPALRICA MP TABLET may cause an increase in the liver enzymes, so it is not recommended for use in patients with severe liver disease. EPALRICA MP TABLET may cause suicidal tendencies in some patients. So, inform your doctor if you notice any mood changes. It may cause dizziness and somnolence (sleepiness). So, it might increase the risk of accidental injury in elderly patients. EPALRICA MP TABLET may also cause temporary vision problems. However, if this condition is persistent, consult your doctor immediately. Patients with diabetes who gain weight with EPALRICA MP TABLET may need a change in diabetic medicines. If you notice urination problems while taking EPALRICA MP TABLET, inform your doctor as EPALRICA MP TABLET may cause kidney failure in some cases. EPALRICA MP TABLET may mask symptoms of vitamin B12 deficiency, so it is necessary to make an accurate diagnosis in patients who are suspected to have a vitamin B12 deficiency. In some cases, EPALRICA MP TABLET may decrease sperm count in men, so ask your doctor about the possible risks before taking this medicine.

Drug-Drug Interactions: EPALRICA MP TABLET may interact with medicines used to treat diabetes (pioglitazone and rosiglitazone), medicines used to treat high blood pressure (lisinopril, captopril, enalapril, and ramipril, etc.), an antibiotic (neomycin), and anti-gout medication (colchicine), and anti-ulcer medicines (cimetidine, ranitidine, famotidine, and omeprazole).

Drug-Food Interactions: Avoid alcohol consumption while using EPALRICA MP TABLET.

Drug-Disease Interactions: EPALRICA MP TABLET should be used with caution in patients with liver diseases, kidney diseases, heart problems, bleeding disorders, lung problems, alcoholism, drug abuse, mood disorders, and suicidal tendencies.

• PIOGLITAZONE
• ROSIGLITAZONE
• LISINOPRIL
• CAPTOPRIL
• ENALAPRIL
• RAMIPRIL
• NEOMYCIN
• COLCHICINE
• CIMETIDINE
• RANITIDINE
• FAMOTIDINE
• OMEPRAZOLE

• Include food rich in vitamin B and D in your diet.
• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
• Exercising regularly helps in improving overall health and combating pain.
• Rest well, get plenty of sleep.
• Try taking a warm bath as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
• Acupuncture can be helpful by stimulating pressure points.
• Using essential oils for massages can help increase circulation.

• While using EPALRICA MP TABLET, the doctor may monitor blood glucose levels, liver function and kidney function regularly. 
• Do not stop taking EPALRICA MP TABLET suddenly as it may cause withdrawal symptoms. The doctor may gradually reduce the dose before completely stopping the therapy.

Diabetic neuropathy: Diabetic neuropathy is seen when nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type1 and type2 diabetes which usually develops slowly. If you have diabetes and experience numbness, pain, tingling sensation, or weakness in the hands or legs, you must consult a doctor. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning, or stabbing pain, difficulty with coordination when walking, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).