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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Sep 30, 2024 | 4:52 PM IST

Emduo E 40 mg/150 mg/600 mg Kit is used in the treatment of HIV infection. It helps decrease the chance of developing AIDS (acquired immunodeficiency syndrome). Emduo E 40 mg/150 mg/600 mg Kit contains Lamivudine, Stavudine and Efavirenz. Collectively, it works by interfering with the functions of nucleotide and nucleoside reverse transcriptase enzymes necessary for virus reproduction. As a result, it helps treat HIV infections.

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Manufacturer/Marketer

Emcure Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Emduo E 40 mg/150 mg/600 mg Kit

Emduo E 40 mg/150 mg/600 mg Kit is used in the treatment of HIV infection. Emduo E 40 mg/150 mg/600 mg Kit helps decrease the chance of developing AIDS (acquired immunodeficiency syndrome). HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help fight infection, making the individual susceptible to other infections or illnesses.

Emduo E 40 mg/150 mg/600 mg Kit contains Lamivudine, Stavudine and Efavirenz. Lamivudine and Stavudine are synthetic nucleoside analogues, and Efavirenz is a non-nucleoside reverse transcriptase inhibitor with activity against the human immunodeficiency virus. Emduo E 40 mg/150 mg/600 mg Kit works by interfering with the functions of nucleotide and nucleoside reverse transcriptase enzymes necessary for virus reproduction. Together, Emduo E 40 mg/150 mg/600 mg Kit helps treat HIV infections.

Emduo E 40 mg/150 mg/600 mg Kit is a prescription medication. You should take this medicine exactly as the doctor prescribed it. The common side effects of Emduo E 40 mg/150 mg/600 mg Kit are nausea, rash, anorexia (an eating disorder), abnormal dreams, dizziness, Fatigue, vomiting, dyspepsia (indigestion), abdominal pain, rash, fever, malaise (general discomfort), asthenia (weakness), headache, and insomnia. Most of these side effects of Emduo E 40 mg/150 mg/600 mg Kit do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Emduo E 40 mg/150 mg/600 mg Kit is not recommended to take Emduo E 40 mg/150 mg/600 mg Kit if you are allergic to any of its contents. Emduo E 40 mg/150 mg/600 mg Kit may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy. Consumption of alcohol may increase the risk of side effects; therefore, avoid alcohol consumption. You should not become pregnant while you are taking Emduo E 40 mg/150 mg/600 mg Kit. Talk to your doctor about effective birth control methods that you can use during your treatment. If you become pregnant while taking Emduo E 40 mg/150 mg/600 mg Kit, call your doctor immediately. You should not breastfeed if you are infected with HIV or if you are taking Emduo E 40 mg/150 mg/600 mg Kit. Emduo E 40 mg/150 mg/600 mg Kit is not recommended for use in children.

Uses of Emduo E 40 mg/150 mg/600 mg Kit

Used for the treatment of HIV infection.

Medicinal Benefits

Emduo E 40 mg/150 mg/600 mg Kit is used in the treatment of HIV infection.It contains Lamivudine, Stavudine and Efavirenz. These medicines work together to prevent the HIV virus from multiplying, which helps reduce the amount of viruses in your body. They help increase the CD4 cell count in your blood. CD4 cells are white blood cells that protect against infection, indicating improved immune function. This combination is part of antiretroviral therapy (ART), which is crucial for managing HIV infection and improving the quality of life for those affected. It’s important to note that while this combination is effective, it may also come with side effects such as dizziness, nausea, and potential liver toxicity. It’s advised to take these medications on an empty stomach, preferably at bedtime, to reduce side effects. To manage any side effects and guarantee the efficacy of the treatment, routine monitoring by a doctor is required.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Emduo E 40 mg/150 mg/600 mg Kit

  • Nausea
  • Rash
  • Anorexia (an eating disorder)
  • Abnormal dreams
  • Dizziness
  • Fatigue
  • Vomiting
  • Dyspepsia (indigestion)
  • Abdominal pain
  • Fever
  • Malaise (general discomfort)
  • Asthenia (weakness)
  • Headache
  • Insomnia

Drug Warnings

Talk to your doctor about the risks and benefits of taking Emduo E 40 mg/150 mg/600 mg Kit. Before taking the Emduo E 40 mg/150 mg/600 mg Kit, inform your doctor about all your medical conditions, sensitivities, and medications you take. Emduo E 40 mg/150 mg/600 mg Kit is not recommended for children. You are advised to take proper precautions if you are infected with HIV to prevent infection from spreading to others through sexual contact or body fluids. If you are pregnant and taking stavudine in addition to didanosine, your risk may increase. Inform your doctor if you have or have previously had a liver illness, which includes hepatitis C virus infection. Stavudine in Emduo E 40 mg/150 mg/600 mg Kit can cause significant or fatal lactic acidosis (a buildup of acid in the blood), which will most likely require hospitalization. Lactic acidosis is more likely to develop if you are a woman, overweight, or have been treated with human immunodeficiency virus (HIV) drugs for an extended time.

Drug Interactions

Drug-Drug Interactions: Emduo E 40 mg/150 mg/600 mg Kit may interact with antirheumatic drugs (e.g. leflunomide, teriflunomide), antifungal medications (e.g. ketoconazole, fluconazole, levoketoconazole), lipid-lowering drugs (e.g. lomitapide), certain other antiviral medications (e.g. atazanavir, tenofovir alafenamide), and certain antibiotics (e.g. ciprofloxacin)

Drug-Food Interactions: Emduo E 40 mg/150 mg/600 mg Kit may interact with alcohol and alcohol-containing beverages. Therefore, avoid alcohol intake and Emduo E 40 mg/150 mg/600 mg Kit as it may increase the risk of adverse effects.

Drug-Disease Interactions: Emduo E 40 mg/150 mg/600 mg Kit may interact with disease conditions, including hepatotoxicity (injury to the liver or impairment of the liver function), pancreatitis (Pancreas inflammation), renal dysfunction (kidney dysfunction), peripheral neuropathy, and bone marrow suppression.

Drug-Drug Interactions Checker List

  • TERIFLUNOMIDE
  • LEFLUNOMIDE
  • KETOCONAZOLE
  • FLUCONAZOLE
  • LEVOKETOCONAZOLE
  • LOMITAPIDE
  • ATAZANAVIR
  • TENOFOVIR ALAFENAMIDE
  • CIPROFLOXACIN

Habit Forming

No

Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injection or drug equipment.
  • Get tested for other sexually transmitted infections, such as gonorrhoea or syphilis, as they can make you prone to HIV infection.
  • Eat a healthy and balanced diet. Choose vitamin—and nutrient-rich foods such as dark green, yellow, orange, and red vegetables and fruits, which help boost your immune system. Choose lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with your family or doing whatever makes you happy.

Special Advise

Attend every appointment with your doctor and laboratory. Your doctor will ask for tests to evaluate your body's response to Emduo E 40 mg/150 mg/600 mg Kit.

Disease/Condition Glossary

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help fight infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. HIV spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (acquired immunodeficiency syndrome). It is a life-long condition, and there is no definite cure. However, it can be controlled by treating it with antiretroviral drugs.

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Alcohol

Caution

Consumption of alcohol should be avoided while on treatment with Emduo E 40 mg/150 mg/600 mg Kit.

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Pregnancy

Caution

Emduo E 40 mg/150 mg/600 mg Kit should be used with caution in pregnant women. It is given only if clinically needed and when the benefits outweigh the risks. When given to a pregnant woman in the first trimester, it could harm the fetus. Women on efavirenz should refrain from getting pregnant. Always use barrier contraception in conjunction with other forms of birth control.

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Breast Feeding

Unsafe

HIV-positive women should refrain from breastfeeding to reduce the risk of HIV infection spreading to their unborn child. This recommendation comes from the Centers for Disease Control and Prevention. Mothers should also be advised not to breastfeed if they are receiving Emduo E 40 mg/150 mg/600 mg Kit due to the possibility of severe adverse reactions in nursing infants.

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Driving

Caution

People with central nervous system symptoms, such as lightheadedness, headaches, and/or sleepiness, should refrain from doing potentially dangerous activities, such as operating machinery or driving a vehicle after taking Emduo E 40 mg/150 mg/600 mg Kit.

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Liver

Caution

The diminished hepatic function did not change pharmacokinetic parameters, so Emduo E 40 mg/150 mg/600 mg Kit dose adjustments for patients with impaired hepatic function are not necessary. The effectiveness and safety of Emduo E 40 mg/150 mg/600 mg Kit have not been proven in the decompensated liver disease being present.

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Kidney

Caution

Patients with reduced renal function (creatinine clearance < 50 mL/min) are not advised to take Emduo E 40 mg/150 mg/600 mg Kit since renal insufficiency necessitates dose modification.

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Children

Unsafe

Emduo E 40 mg/150 mg/600 mg Kit is not recommended for children below 12 years.

Country of origin

India
Other Info - EM12496

FAQs

Emduo E 40 mg/150 mg/600 mg Kit is used to treat HIV infection.
Emduo E 40 mg/150 mg/600 mg Kit contains Lamivudine, Stavudine and Efavirenz. Emduo E 40 mg/150 mg/600 mg Kit acts by inhibiting the activity of nucleotide and nucleoside reverse transcriptase enzymes required for virus replication. Together, Emduo E 40 mg/150 mg/600 mg Kit helps to cure HIV infections.
Emduo E 40 mg/150 mg/600 mg Kit does not cure HIV infection. Emduo E 40 mg/150 mg/600 mg Kit reduces the amount of HIV in the body and improves the immune system's functioning.
HIV infection may still be transmitted to other persons while using Emduo E 40 mg/150 mg/600 mg Kit. Emduo E 40 mg/150 mg/600 mg Kit reduces the risk of transmission, but still, HIV infection is contagious. Therefore, discuss with a doctor regarding precautions to avoid transmission of HIV while taking Emduo E 40 mg/150 mg/600 mg Kit.
No, Emduo E 40 mg/150 mg/600 mg Kit should be taken in the dose and duration as the doctor advises. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
Do not stop taking Emduo E 40 mg/150 mg/600 mg Kit without consulting your doctor and without completing the prescribed course, as abrupt stopping may worsen your condition or it can lead to other infections. If you find difficulty using Emduo E 40 mg/150 mg/600 mg Kit, seek immediate medical help.

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