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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Eldepryl 10mg Tablet is used in the treatment of Parkinson's disease. It contains Selegiline, which increases the level of dopamine and restores its level in the brain. Thereby, improves the symptoms of Parkinson's disease. Some people may experience a sore mouth, swollen gums, loss of balance, difficulty in controlling movements, headache, dizziness, nausea, sleep disorders, mouth ulcers or constipation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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rxMedicinePrescription drug

Whats That

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Composition :

SELEGILINE-10MG

Manufacturer/Marketer :

Themis Medicare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Eldepryl 10mg Tablet

Eldepryl 10mg Tablet belongs to a class of antiparkinson drugs called monoamine oxidase-B inhibitors used in the treatment of Parkinson’s disease. Parkinson’s disease is a central nervous system disorder that affects movement. It causes stiffness, shaking, difficulty in walking, coordination and balance. In Parkinson’s patients, there is a decrease in dopamine (a chemical messenger that is important for movement control) levels as the nerve cells that produce dopamine begin to die.

Eldepryl 10mg Tablet contains Selegiline that works by inhibiting the action of an enzyme called monoamine oxidase-B that naturally breaks down dopamine. Thereby, increases the level of dopamine and restores its level in the brain thereby improving the symptoms of Parkinson’s disease.

Take Eldepryl 10mg Tablet with or without food as advised by your doctor and swallow whole with a glass of water. Do not crush, chew or break it. Your doctor will advise you how often you take Eldepryl 10mg Tablet based on your medical condition. Some people may experience a sore mouth, swollen gums, loss of balance, difficulty in controlling movements, headache, dizziness, nausea, sleep disorders, mouth ulcers or constipation. Most of these side effects of Eldepryl 10mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Eldepryl 10mg Tablet or any other medicines, please tell your doctor. Avoid taking Eldepryl 10mg Tablet if you are pregnant or breastfeeding and consult a doctor. Eldepryl 10mg Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Eldepryl 10mg Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Eldepryl 10mg Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, any unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Eldepryl 10mg Tablet.

Uses of Eldepryl 10mg Tablet

Treatment of Parkinson's disease.

Directions for Use

Take Eldepryl 10mg Tablet as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, break or chew it.

Medicinal Benefits

Eldepryl 10mg Tablet is an antiparkinson agent that is used in the treatment of Parkinson’s disease. In Parkinson’s patients, the nerve cells that produce dopamine (a chemical messenger that is important for movement control) begin to die. So, there is a decrease in dopamine levels. Eldepryl 10mg Tablet works by inhibiting the action of the monoamine oxidase-B enzyme that naturally breaks down dopamine. Thereby, increases dopamine in the brain and restores its levels. Thus, it improves the symptoms of Parkinson’s disease. Eldepryl 10mg Tablet can be used alone or in combination with other medicines such as levodopa to reduce uncontrolled movements.

How Eldepryl 10mg Tablet Works

Eldepryl 10mg Tablet contains Selegiline that works by inhibiting the action of an enzyme called monoamine oxidase-B that naturally breaks down dopamine. Thereby, increases the level of dopamine and restores its level in the brain thereby improving the symptoms of Parkinson’s disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Eldepryl 10mg Tablet

  • Sore mouth
  • Swollen gums
  • Loss of balance
  • Difficulty in controlling movements
  • Headache
  • Dizziness
  • Nausea
  • Sleep disorders
  • Mouth ulcers
  • Constipation

What if I have taken an overdose of Eldepryl 10mg Tablet

Do not take more than the prescribed dose of Eldepryl 10mg Tablet as it may cause overdose. The symptoms of overdose include dizziness, fainting, drowsiness, agitation, irritability, hallucinations, severe headache, seizures (fits), or sweating. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Eldepryl 10mg Tablet or any other medicines, please tell your doctor. Avoid taking Eldepryl 10mg Tablet if you are pregnant or breastfeeding and consult a doctor. Eldepryl 10mg Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Eldepryl 10mg Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Eldepryl 10mg Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of the prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Eldepryl 10mg Tablet.

Drug-Drug Interactions

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SelegilineAtomoxetine
Critical
SelegilineAmitriptyline
Critical

Drug-Drug Interactions

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SelegilineAtomoxetine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Eldepryl 10mg Tablet with Atomoxetine can increase the risk of high blood pressure.

How to manage the interaction:
Taking Eldepryl 10mg Tablet with Atomoxetine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience sudden and severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
SelegilineAmitriptyline
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Amitriptyline together with Eldepryl 10mg Tablet can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Eldepryl 10mg Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SelegilineDexamfetamine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Dextroamphetamine with Eldepryl 10mg Tablet can increase the blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Dexamphetamine and Eldepryl 10mg Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting-call a doctor right away. Do not stop using any medications without a doctor's advice.
SelegilineNortriptyline
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Nortriptyline with Eldepryl 10mg Tablet might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Nortriptyline with Eldepryl 10mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SelegilineCitalopram
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Eldepryl 10mg Tablet with Citalopram can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Eldepryl 10mg Tablet with Citalopram together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
SelegilineDuloxetine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Taking duloxetine with Eldepryl 10mg Tablet may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Duloxetine and Eldepryl 10mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
SelegilineParoxetine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
When Paroxetine is taken with Eldepryl 10mg Tablet, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Paroxetine with Eldepryl 10mg Tablet can possibly lead to an interaction but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SelegilineClomipramine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Eldepryl 10mg Tablet can increase the effects of Clomipramine on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Eldepryl 10mg Tablet with Clomipramine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
SelegilineDextromethorphan
Critical
How does the drug interact with Eldepryl 10mg Tablet:
Co-administration of Dextromethorphan and Eldepryl 10mg Tablet may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Eldepryl 10mg Tablet with Dextromethorphan can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
SelegilineMephentermine
Critical
How does the drug interact with Eldepryl 10mg Tablet:
When Mephentermine is combined with Eldepryl 10mg Tablet, may increase the risk of high blood pressure.

How to manage the interaction:
Mephentermine with Eldepryl 10mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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SELEGILINE-10MGTyramine-containing food
Moderate

Drug-Food Interactions

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SELEGILINE-10MGTyramine-containing food
Moderate
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Consuming Eldepryl 10mg Tablet with Tyramine-containing food it may increase the blood pressure. Avoid consuming Eldepryl 10mg Tablet with Tyramine-containing food.

Diet & Lifestyle Advise

  • Avoid intake of tyramine rich foods such as broad beans, Bovril, mature cheese, fermented soya bean products or yeast extracts.
  • Eat more fibre rich foods to ease constipation.
  • Drink plenty of water to avoid headaches due to dehydration.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Eldepryl 10mg Tablet Substitute

Substitutes safety advice
  • Selgin 10 mg Tablet 10's

    by Others

    8.46per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Eldepryl 10mg Tablet as it may increase the risk of adverse effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Eldepryl 10mg Tablet is a Category C pregnancy drug and is usually not recommended for pregnant women. Please consult a doctor if you are pregnant as Eldepryl 10mg Tablet is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Unsafe

Eldepryl 10mg Tablet is not recommended for breastfeeding mothers. However, please consult a doctor before taking Eldepryl 10mg Tablet if you are a breastfeeding mother.

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Driving

Unsafe

Eldepryl 10mg Tablet may cause drowsiness or dizziness and make you fall asleep suddenly. It is an offence to drive if Eldepryl 10mg Tablet affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking Eldepryl 10mg Tablet.

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Liver

Caution

Take Eldepryl 10mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Eldepryl 10mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Eldepryl 10mg Tablet is not recommended for children as the safety and efficacy were not established.

FAQs

Eldepryl 10mg Tablet is used in the treatment of Parkinson's disease.

Eldepryl 10mg Tablet contains Selegiline, an antiparkinson agent that works by inhibiting the action of monoamine oxidase-B enzyme that naturally breaks down dopamine. Thereby, increases dopamine in the brain and restores its levels. Thus, improves the symptoms of Parkinson’s disease.

You recommend avoiding tyramine rich foods such as broad beans, Bovril, mature cheese, fermented soya bean products or yeast extracts as it may cause severe high blood pressure.

Eldepryl 10mg Tablet may cause low blood pressure in some patients, especially while standing up suddenly from a sitting or lying down position and cause symptoms such as dizziness, sweating, nausea or fainting. Hence, to avoid orthostatic hypotension, you are recommended to get up slowly after lying down or sitting.

Eldepryl 10mg Tablet is not recommended for glaucoma (damage of optic nerve that is essential for good vision) patients as it may increase the fluid pressure inside the eye. However, regular monitoring of pressure in the eyes is recommended while on treatment with Eldepryl 10mg Tablet.

You are recommended to avoid taking Eldepryl 10mg Tablet with escitalopram as it may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, diarrhoea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking Eldepryl 10mg Tablet with other medicines.

No, Eldepryl 10mg Tablet does not cure Parkinson’s disease. Eldepryl 10mg Tablet is only used to reduce the symptoms of Parkinson’s disease.

Eldepryl 10mg Tablet should not be used with pain killers like meperidine, tramadol, methadone, propoxyphene and cough syrups containing dextromethorphan. Using together can cause severe side effects and can worsen your present condition.

Eldepryl 10mg Tablet is safe if used in the dose and duration prescribed by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor’s instructions carefully and inform your doctor if you experience any side effects.

Eldepryl 10mg Tablet which contains selegiline, is not classified as a stimulant. However, it can have stimulating effects on the brain, such as causing mood changes, anxiety, agitation, hallucinations, confusion, and sleep disturbances.

No, Eldepryl 10mg Tablet is not considered addictive. However, use Eldepryl 10mg Tablet as prescribed by your doctor. Do not exceed the recommended dose.

Yes, Eldepryl 10mg Tablet should be tapered (changing dose) gradually under the guidance of your doctor. It should not be suddenly stopped as it can cause confusion, sweating, stiff muscles, and high fever. Your doctor will provide a tapering schedule to safely reduce your dosage.

Yes, Eldepryl 10mg Tablet is considered neuroprotective. It helps slow down the progression of Parkinson's disease by increasing the amount of dopamine in the brain, which is essential for controlling movement.

Eldepryl 10mg Tablet can cause weight loss in some individuals. However, not everyone will experience this side effect. Take a balanced diet with sufficient calories, proteins, fats, and carbohydrates to manage this side effect.

The common side effects of Eldepryl 10mg Tablet are sore mouth, swollen gums, loss of balance, difficulty in controlling movements, headache, dizziness, nausea, sleep disorders, mouth ulcers or constipation. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - EL49997

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