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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Duovir Tablet is used to treat HIV infection. It contains Lamivudine and Zidovudine which work by preventing the virus from multiplying, thereby reducing viral load in the body. In some cases, this medicine may cause side effects such as nausea, diarrhoea, headache, fatigue, cough, a feeling of discomfort, and stuffy nose. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Duovir Tablet

Duovir Tablet belongs to the class of medicines called 'anti-retroviral agents', used for the treatment of immunodeficiency virus (HIV) infection. HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body.

Duovir Tablet contains lamivudine and zidovudine. Duovir Tablet works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.

Take Duovir Tablet as advised by your doctor. Duovir Tablet may cause common side effects like nausea, diarrhoea, headache, fatigue, cough, a feeling of discomfort, and nasal congestion (stuffy nose). Most of these side effects gradually resolve over time and do not require medical attention. However, if these side effects persist or worsen, please consult your doctor immediately.

Inform your doctor if you are allergic to any of the components in Duovir Tablet . Please consult your doctor if you are pregnant, planning to conceive or breastfeeding. Let your doctor know if you have kidney, liver, or pancreatic disease. Please tell your doctor if you have a low red blood cell count (anaemia), low white blood cell count (neutropenia), osteonecrosis (death of bone tissue due to a lack of blood supply), or lactic acidosis.

Uses of Duovir Tablet

Treatment of Human immunodeficiency virus (HIV) infection

Directions for Use

Swallow Duovir Tablet as a whole with a glass of water. Do not chew, crush or break it.

Medicinal Benefits

Duovir Tablet contains a combination of two medicines, namely: lamivudine and zidovudine, that belong to the group of medications called anti-retroviral agents. Duovir Tablet is primarily used for the treatment of human immunodeficiency virus (HIV) infection. Duovir Tablet works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.

How Duovir Tablet Works

Duovir Tablet contains lamivudine and zidovudine. Duovir Tablet works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Duovir Tablet

  • Nausea
  • Diarrhoea
  • Stomach pain
  • Loss of appetite
  • Tiredness
  • Lack of energy
  • Fever (high temperature)
  • Headache
  • Hair loss (alopecia)
  • Fatigue
  • Cough
  • Muscle pain and discomfort
  • Joint pain
  • Feeling of discomfort
  • Difficulty in sleeping (insomnia)
  • Irritated or runny nose

What if I have taken an overdose of Duovir Tablet

Take Duovir Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include headache, vomiting, and extreme tiredness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you are allergic to any of the components in Duovir Tablet . Please consult your doctor if you are pregnant, planning to conceive or breastfeeding. Let your doctor know if you have kidney, liver, pancreatic, or bone marrow suppression. Please tell your doctor if you have a low red blood cell count (anaemia), low white blood cell count (neutropenia), osteonecrosis (death of bone tissue due to a lack of blood supply), lactic acidosis, or opportunistic infections. Duovir Tablet may cause muscle disorders, especially when used for a long period. Tell your doctor if you have or have ever had any disease of the muscles or muscle weakness. If you experience muscle pain or muscle weakness, call your doctor immediately.

Drug-Drug Interactions

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LamivudineEmtricitabine
Critical
LamivudineZalcitabine
Severe

Drug-Drug Interactions

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LamivudineEmtricitabine
Critical
How does the drug interact with Duovir Tablet 60's:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Emtricitabine with Duovir Tablet 60's is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
LamivudineZalcitabine
Severe
How does the drug interact with Duovir Tablet 60's:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Although there is a possible interaction between Duovir Tablet 60's and Zalcitabine, you can take these medicines together if prescribed by your doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
LamivudineLomitapide
Severe
How does the drug interact with Duovir Tablet 60's:
Taking Duovir Tablet 60's and lomitapide together can increase the risk of liver damage

How to manage the interaction:
There may be a possibility of interaction between Duovir Tablet 60's and Lomitapide, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include fever, rash, itching, loss of appetite, feeling sick, feeling tired, feeling unwell, pain in the upper right side of your stomach, dark urine, yellowing of the skin or eyes, chills, joint pain, swelling, bruising, stomach pain, liver damage, or bleeding. Do not stop using any medications without a doctor's advice.
LamivudineSorbitol
Severe
How does the drug interact with Duovir Tablet 60's:
Duovir Tablet 60's can cause higher levels of Sorbitol in the blood by reducing its excretion rate.

How to manage the interaction:
Taking Sorbitol with Duovir Tablet 60's together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
LamivudineLeflunomide
Severe
How does the drug interact with Duovir Tablet 60's:
Combining Duovir Tablet 60's with Leflunomide can increase the risk and severity of muscle problems.

How to manage the interaction:
Although there is a possible interaction between Duovir Tablet 60's and Leflunomide, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms it's important to contact your doctor right away: fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine or bleeding. Do not stop using any medications without talking to your doctor.
LamivudineTeriflunomide
Severe
How does the drug interact with Duovir Tablet 60's:
Teriflunomide can cause Duovir Tablet 60's to stay in the body longer, leading to higher levels in the blood.

How to manage the interaction:
Although there is a possible interaction between Duovir Tablet 60's and Teriflunomide, you can take these medicines together if prescribed by your doctor. If you have any of these signs and symptoms, contact your doctor immediately: fever, chills, pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.
LamivudineBexarotene
Severe
How does the drug interact with Duovir Tablet 60's:
Taking bexarotene together with Duovir Tablet 60's increases the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
There may be a possibility of interaction between Duovir Tablet 60's and Bexarotene, but it can be taken if prescribed by a doctor. If you're having symptoms like nausea, vomiting, or abdominal pain, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
LamivudineMipomersen
Severe
How does the drug interact with Duovir Tablet 60's:
Taking Duovir Tablet 60's and mipomersen together can increase the risk of liver damage.

How to manage the interaction:
Although taking Duovir Tablet 60's and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include fever, rash, itching, loss of appetite, feeling sick, feeling tired, pain in the upper right side of your belly, dark urine, yellowing of the skin or eyes, chills, joint pain, swelling, bruising, loss of appetite, and bleeding. Do not stop using any medications without talking to your doctor.
ZidovudineEtanercept
Severe
How does the drug interact with Duovir Tablet 60's:
When Etanercept is used with Duovir Tablet 60's, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Etanercept with Duovir Tablet 60's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
ZidovudineInfliximab
Severe
How does the drug interact with Duovir Tablet 60's:
When Duovir Tablet 60's and Infliximab are taken together, the body breaks down Duovir Tablet 60's faster. This can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Duovir Tablet 60's together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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LAMIVUDINE-150MG+ZIDOVUDINE-300MGHigh fat foods
Mild

Drug-Food Interactions

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LAMIVUDINE-150MG+ZIDOVUDINE-300MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Consuming high-fat foods along with Duovir Tablet 60's may decrease its effectiveness. Avoid or limit the consumption of high-fat foods with Duovir Tablet 60's as it can increase the risk of side effects.

Diet & Lifestyle Advise

  • Take a diet high in vegetables, fruits, whole grains, and legumes.
  • Choose lean, low-fat sources of protein.
  • Limit sweets, soft drinks, and foods with added sugar. 
  • Take proteins, carbohydrates, and a good little fat in all meals and snacks in your regular diet.
  • Avoid eating raw eggs, meats, or seafood (including sushi and oysters/shellfish).
  • Wash fruits and vegetables thoroughly.
  • Use a separate cutting board for raw meats.
  • Wash hands, utensils, and cutting boards with soap and water after each use.
  • Exercise regularly. 
  • Avoid excessive alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Duovir Tablet Substitute

Substitutes safety advice
  • Lazid Tablet 60's

    21.25per tablet
  • VIROCOMB FC 150MG TABLET

    18.55per tablet
  • ZIDOVEX L TABLET

    19.17per tablet
  • Duovir Tablet 10's

    19.39per tablet
  • Zovilam 150mg/300mg Tablet

    18.68per tablet
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Alcohol

Caution

Duovir Tablet with alcohol can cause unpleasant side effects. So please consult your doctor before consumption of alcohol while taking Duovir Tablet .

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Pregnancy

Caution

Duovir Tablet is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

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Breast Feeding

Caution

Duovir Tablet is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or breastfeeding based on your clinical condition.

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Driving

Caution

Duovir Tablet may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.

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Liver

Caution

Duovir Tablet should be used with caution in liver patients due to the increased risk of worsening the patient's condition. So please consult your doctor before taking Duovir Tablet .

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Kidney

Caution

Duovir Tablet should be used with caution in kidney patients due to the increased risk of serious side effects. So please consult your doctor before taking Duovir Tablet .

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Children

Caution

Duovir Tablet should be used with caution in Children. Your doctor may prescribe Duovir Tablet by adjusting the dose based on the height and weight of the children.

FAQs

Duovir Tablet is used to treat HIV infection.
Duovir Tablet works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.
Duovir Tablet should be used with proper caution and doctor consultation if you have kidney disease, liver disease, pancreatic disease, low red blood cell count (anaemia), low white blood cell count (neutropenia), osteonecrosis (death of bone tissue due to a lack of blood supply), or lactic acidosis.
Stopping Duovir Tablet may increase the risk of treatment failure. So Duovir Tablet should not be stopped without consulting your doctor.
Please consult your doctor if you are using other medicines before starting Duovir Tablet . However, medicines like didanosine, co-trimoxazole, clarithromycin, fluconazole, rifampicin, ranitidine, and phenytoin may interact with Duovir Tablet and should not be used simultaneously.
Duovir Tablet belongs to anti-retroviral drugs used to treat HIV (human immunodeficiency virus) infection. HIV attacks the immune system, and without treatment, it can progress to AIDS (acquired immunodeficiency syndrome). This medication does not cure HIV but helps to prevent the virus from multiplying in your body, thereby reducing the viral load. It also helps increase the count of CD4 cells, which are white blood cells that protect the body against infections.
Yes, Duovir Tablet is safe if taken in the dose and duration exactly as prescribed by the doctor.
Duovir Tablet should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.
Yes, Duovir Tablet is effective in treating HIV (human immunodeficiency virus) infection. It works by inhibiting the replication of the virus, thus helping to reduce the viral load in the body and preventing the progression of HIV to AIDS. However, it is not a cure for HIV, it should be taken as part of a complete antiretroviral therapy (ART) plan, as prescribed by the doctor.
If you forget to take a dose of Duovir Tablet , take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
The side effects of Duovir Tablet include fatigue, nausea, diarrhoea, headache, cough, a feeling of discomfort, and nasal congestion (stuffy nose). Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DUO0037

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