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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:39 PM IST
Duovir-N Tablet is used for the treatment of HIV infection. It works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body and also increasing the CD4 cell (white blood cells that protect against infection) count in your blood. It may cause common side effects such as nausea, vomiting, diarrhea, headache, tiredness, insomnia (difficulty in sleeping), rash, and muscle damage. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. It can cause birth defects; so use effective contraception while taking this medicine, and for 12 weeks after stopping it.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Cipla Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Duovir-N Tablet

Duovir-N Tablet is a combination of three drugs: lamivudine, zidovudine, and nevirapine. Duovir-N Tablet works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body and also increasing the CD4 cell (white blood cells that protect against infection) count in your blood. Duovir-N Tablet is generally prescribed for the treatment of HIV infection.

lamivudine and zidovudine is nucleosidase reverse transcriptase inhibitor, both medicines together decrease the amount of virus in your body by inhibiting HIV reverse transcription via viral DNA chain termination, whereas Niverapine is a non-nucleosidase reverse transcriptase inhibitor, works by lowering the amount of HIV in the blood. Duovir-N Tablet  will not cure HIV infection or AIDS, however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.

Take Duovir-N Tablet by mouth with a glass full of water.  Take it on an empty stomach, preferably at bedtime, to reduce side effects. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Common side effects of Duovir-N Tablet are Nausea, Vomiting, Diarrhea, Headache, Tiredness, Insomnia (difficulty in sleeping), Rash, Muscle damage, Anemia (low number of red blood cells), and Decreased white blood cell count (neutrophils).

Duovir-N Tablet should not be prescribed for people who are allergic to any one of the components in the name. $ name carries a boxed warning for the risk of life-threatening (including fatal) hepatotoxicity, skin reactions, hematologic toxicity, myopathy, lactic acidosis and severe hepatomegaly with steatosis, and exacerbations of hepatitis B. Duovir-N Tablet may cause dizziness or sleepiness, so don't drive or do anything requiring concentration until you know how it affects you. It can cause birth defects, use effective contraception while taking Duovir-N Tablet , and 12 weeks after stopping it. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Do not stop taking Duovir-N Tablet without your doctor’s advice.

Uses of Duovir-N Tablet

Treatment of Human immunodeficiency virus infection.

Medicinal Benefits

Duovir-N Tablet is a combination of three medicines that slows down or stops the progression of HIV infections. Duovir-N Tablet work by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood. Duovir-N Tablet is also used in preventing pregnancy complications.

Directions for Use

Take it on an empty stomach, preferably at bedtime, to reduce side effects or take it as advised by the doctor. Swallow it as a whole with a glass of water. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Duovir-N Tablet

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Tiredness
  • Insomnia (difficulty in sleeping)
  • Rash
  • Muscle damage
  • Anemia (low number of red blood cells)
  • Decreased white blood cell count (neutrophils)
  • Chills and fever
  • Indigestion
  • Difficulty with bowel movements

Drug Warnings

Duovir-N Tablet should not be prescribed for people who are allergic to any one of the components in the name. Duovir-N Tablet carries a boxed warning for the risk of life-threatening (including fatal) hepatotoxicity, skin reactions, hematologic toxicity, myopathy, lactic acidosis and severe hepatomegaly with steatosis, and exacerbations of hepatitis B. Duovir-N Tablet may cause dizziness or sleepiness, so don't drive or do anything requiring concentration until you know how it affects you. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Do not stop taking Duovir-N Tablet without your doctor’s advice.

Drug Interactions

Drug-Drug Interaction: Care should be exercised when Duovir-N Tablet is administered in combination with antibiotics(clarithromycin, chloramphenicol, Doxorubicin),  anti-viral (acyclovir, atazanavir, efavirenz),anti-fungal(fluconazole, ketoconazole).

Drug-Food Interaction: avoid taking alcohol and st .johnwarts with Duovir-N Tablet .

Drug-Disease Interaction: People affected with liver disease, kidney disease, blood disorders, and Bone disorders should not take Duovir-N Tablet .

Drug-Drug Interactions Checker List

  • EFAVIRENZ
  • INDINAVIR
  • RITONAVIR
  • CHLORAMPHENICOL
  • CARBAMAZEPINE
  • FLUCONAZOLE
  • KETOCONAZOLE
  • GANCICLOVIR
  • LOPINAVIR

Habit Forming

No

Diet & Lifestyle Advise

  • Getting moderate exercise. Being physically active three to six times a week can help improve your mood and outlook and improve your overall quality of life.
  • quit smoking and avoid alcohol
  •  Take healthy diet for someone living with HIV is one that is rich in whole grains, low-fat dairy products, protein, and lots of fresh fruits and vegetables.
  •  If you have HIV, you can get infections more easily. so always wash your hands well and often, and practice good food safety to avoid foodborne illness.

Special Advise

  • Take it on an empty stomach, preferably at bedtime, to reduce side effects.
  • Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
  • $ name can cause congenital disabilities. Use effective contraception while taking Lamivudine + Zidovudine + Nevirapine and 12 weeks after stopping it.
  • Duovir-N Tablet may cause the weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
  • Your doctor may monitor your kidney and liver functions regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine, or yellowing of the eyes or skin.

Disease/Condition Glossary

HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). There is currently no effective cure. Once people get HIV, they have it for life. But with proper medical care, HIV can be controlled. People with HIV who get effective treatment can live long, healthy lives and protect their partners. Some people have flu-like symptoms within 2 to 4 weeks after infection (called acute HIV infection). These symptoms may last for a few days or several weeks. Possible symptoms include Fever, Chills, Rash, Night sweats, Muscle aches, Sore throat, Fatigue, Swollen lymph nodes, and Mouth ulcers.

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Alcohol

Unsafe

Duovir-N Tablet with alcohol causes liver damage. so Inform Your doctor while prescribing the Duovir-N Tablet .

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Pregnancy

Caution

Duovir-N Tablet can be used in pregnancy by the advice of your doctor because studies do not show any defects in the unborn baby as Duovir-N Tablet passes through the placenta.

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Breast Feeding

Caution

Duovir-N Tablet can be used in breastfeeding mothers by the advice of your doctor because studies do not show any defects in baby as Duovir-N Tablet passes through breast milk.

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Driving

Unsafe

Duovir-N Tablet may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.

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Liver

Caution

If you take Duovir-N Tablet , Your doctor may monitor your liver functions regularly. Inform your doctor if you develop abdominal pain symptoms, loss of appetite, yellowing of the eyes or skin. If needed dose adjustments can be made by your doctor.

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Kidney

Caution

If you take Duovir-N Tablet , Your doctor may monitor your kidney functions regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite darkened urine. If needed dose adjustments can be done by your doctor.

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Children

Unsafe

Duovir-N Tablet cannot be used in children below 12 years. If their age is >35 can be prescribed and dose adjustments can be done by your doctor.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DUO0032

FAQs

Duovir-N Tablet is used for the treatment of HIV infection.
Skipping doses of Duovir-N Tablet increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
Yes,Duovir-N Tablet cause the weakening of bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Patients taking nevirapine one of the component of Duovir-N Tablet may develop severe liver disease or skin reactions that can cause death. The risk of these reactions is greatest during the first 18 weeks of treatment, but these reactions also can occur later.

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