Duotrol SR Tablet is used in treating type 2 diabetes mellitus. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance).

Duotrol SR Tablet contains Metformin and Glibenclamide. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.

Take Duotrol SR Tablet as prescribed by your doctor. You are advised to take Duotrol SR Tablet for as long as your doctor has prescribed it based on your medical condition. Sometimes, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or low blood sugar. Most of these side effects of Duotrol SR Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not consume if you are allergic to any components in the Duotrol SR Tablet . Duotrol SR Tablet is not recommended for children. If you are pregnant or planning for pregnancy, please inform your doctor before taking Duotrol SR Tablet . Duotrol SR Tablet should be used with caution in elderly patients. Avoid alcohol consumption with Duotrol SR Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Duotrol SR Tablet .

Duotrol SR Tablet contains Metformin and Glibenclamide. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Together Duotrol SR Tablet decreases the elevated blood sugar level after the meal along with the recommended diet and exercise.

• Nausea 
• Vomiting
• Diarrhoea
• Stomach ache
• Loss of appetite

Do not take Duotrol SR Tablet if you are allergic to metformin, glibenclamide or other contents. Duotrol SR Tablet may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems, as their normal functioning is required to eliminate excess lactic acid from the body. Do not consume excess alcohol, as it increases the risk of lactic acidosis. Inform your doctor if you have any hormonal problems, infectious diseases, or glucose-6-phosphate dehydrogenase - G6PD deficiency (an inherited condition that causes the breakdown of red blood cells).

Drug-Drug interactions: Inform the doctor if you are taking an antifungal drug (miconazole) or iodine contrast agents (used for X-ray or scan) while using Duotrol SR Tablet . Duotrol SR Tablet may interact with medications used to treat high blood pressure like (ritodrine, salbutamol, terbutaline, and bosentan), bile acid sequestrants (lower cholesterol levels), drugs used to treat skin inflammation such as corticosteroids, a drug used for diagnosis of adrenocortical insufficiency (tetracosactide), pain killer (phenylbutazone), antifungal drug (fluconazole), a medication used to treat mental illness (chlorpromazine), a medication used to reduce urine production (desmopressin), and medication used to treat endometriosis (danazol).

Drug-Food interactions: No interactions found.

Drug-Disease interactions: Duotrol SR Tablet should be used with caution in patients with liver, kidney, hormonal, infectious, and heart problems.

• MICONAZOLE
• RITODRINE
• SALBUTAMOL
• BOSENTAN
• PHENYLBUTAZONE
• FLUCONAZOLE
• CHLORPROMAZINE
• DESMOPRESSIN
• DANAZOL

• Prefer eating a meal that contains plenty of vegetables, fruits and whole grains. Opt for non-fat dairy products and lean meats.
• Eat at regular intervals. Do not take a long gap between a meal or snack.
• Monitor your blood glucose levels regularly as advised by your doctor.
• Keep a check on your weight. Shed excess weight by exercising regularly.
• Do not take stress as it shows the effect on blood sugar levels.
• Quit smoking and limit alcohol intake.

• Duotrol SR Tablet shows optimum effects when you follow healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc.

Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin or in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. If not properly treated, this condition may worsen over time and cause toxic effects.