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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Doxybuz 100 mg Injection is an antibiotic medicine used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections, and periodontitis. This medicine contains doxycycline which works by inhibiting the protein synthesis of the bacterial cell and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea.
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Whats That

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Composition :

DOXYCYCLINE-100MG

Manufacturer/Marketer :

Alniche Life Sciences Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Doxybuz 100 mg Injection

Doxybuz 100 mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxybuz 100 mg Injection may also be used to treat or prevent anthrax.

Doxybuz 100 mg Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxybuz 100 mg Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Doxybuz 100 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Doxybuz 100 mg Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Doxybuz 100 mg Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Doxybuz 100 mg Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Doxybuz 100 mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Doxybuz 100 mg Injection

Treatment of Bacterial infections

Directions for Use

Doxybuz 100 mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Doxybuz 100 mg Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

How Doxybuz 100 mg Injection Works

Doxybuz 100 mg Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxybuz 100 mg Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Doxybuz 100 mg Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

What if I have taken an overdose of Doxybuz 100 mg Injection

Doxybuz 100 mg Injection is administered by a healthcare professional in a hospital setting. Hence, the chances of overdose are less. Overdose can cause nausea, vomiting, diarrhea, photosensitivity (skin reaction to the sun), indigestion, loss of appetite and mild rash. Your doctor may initiate necessary treatment if an overdose is suspected.

Drug Warnings

Do not take Doxybuz 100 mg Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Doxybuz 100 mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
DoxorubicinBaricitinib
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Doxybuz 100 mg Injection:
Coadministration of Doxybuz 100 mg Injection with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Doxybuz 100 mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinBaricitinib
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Combining Doxybuz 100 mg Injection with Baricitinib can increase the likelihood and seriousness of side effects.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Doxybuz 100 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
DoxorubicinChloroquine
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Using chloroquine together with doxurubicin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Doxybuz 100 mg Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinGatifloxacin
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Taking Gatifloxacin and Doxybuz 100 mg Injection can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Doxybuz 100 mg Injection together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxorubicinDisopyramide
Severe
How does the drug interact with Doxybuz 100 mg Injection:
The combined use of Doxybuz 100 mg Injection and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Doxybuz 100 mg Injection and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinHaloperidol
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Co-administration of Doxybuz 100 mg Injection and Haloperidol can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Doxybuz 100 mg Injection with Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinAmisulpride
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Using Amisulpride together with Doxybuz 100 mg Injection can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Doxybuz 100 mg Injection and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinEtanercept
Severe
How does the drug interact with Doxybuz 100 mg Injection:
When Etanercept is used with Doxybuz 100 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Doxybuz 100 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinNilotinib
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Coadministration of Doxybuz 100 mg Injection and Nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxybuz 100 mg Injection and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxorubicinBaricitinib
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Using baricitinib together with Doxybuz 100 mg Injection may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Doxybuz 100 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Doxybuz 100 mg Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Doxybuz 100 mg Injection.
  • Avoid intake of alcoholic beverages with Doxybuz 100 mg Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Doxybuz 100 mg Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Doxybuz 100 mg Injection Substitute

Substitutes safety advice
  • Doxy T 100 Capsule 8's

    by AYUR

    4.50per tablet
  • Minicycline Capsule 10's

    by Others

    3.11per tablet
  • Codox Capsule 10's

    by Others

    3.11per tablet
  • Pepdox 100 Capsule 10's

    by Others

    9.45per tablet
  • Dox-100 Tablet 8's

    by Others

    3.89per tablet
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Alcohol

Caution

It is not known if alcohol affects Doxybuz 100 mg Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Doxybuz 100 mg Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Doxybuz 100 mg Injection in pregnant women. In some cases, taking Doxybuz 100 mg Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Doxybuz 100 mg Injection.

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Breast Feeding

Caution

Doxybuz 100 mg Injection is excreted in the breast milk. However, the extent of absorption of Doxybuz 100 mg Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Doxybuz 100 mg Injection.

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Driving

Caution

It is not known if Doxybuz 100 mg Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Doxybuz 100 mg Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Doxybuz 100 mg Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Doxybuz 100 mg Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

FAQs

Doxybuz 100 mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxybuz 100 mg Injection may also be used to treat or prevent anthrax.

Doxybuz 100 mg Injection stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxybuz 100 mg Injection helps treat bacterial infections.

No, Doxybuz 100 mg Injection should not be stopped even if you feel better as it is an antibiotic medication and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form and will also become difficult to treat due to antibiotic resistance.

If you are taking Doxybuz 100 mg Injection, avoid taking antacids containing aluminium, calcium or magnesium or other drugs containing these cations; oral zinc, iron salts or bismuth preparations within 2 hours of consumption of Doxybuz 100 mg Injection as they may affect the absorption of Doxybuz 100 mg Injection. Avoid taking dairy products within 2 hours of taking Doxybuz 100 mg Injection as they may also impair the absorption of Doxybuz 100 mg Injection.

Use of Doxybuz 100 mg Injection during tooth development (last half of pregnancy, infancy, and in children below the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.

Doxybuz 100 mg Injection may make your skin sensitive to sunlight. So, apply sunscreen while going out and wear protective clothing and sunglasses. Avoid prolonged and unnecessary exposure to sunlight.

Doxybuz 100 mg Injection may lower the effectiveness of hormonal contraceptives such as birth control pills, rings, patches, or injections. Consult your doctor if you have any concerns, your doctor may advise regarding other forms of contraception.

Doxybuz 100 mg Injection does not completely prevent malaria caused by P. falciparum as Doxybuz 100 mg Injection is given as a prophylactic regimen (protection) whenever anyone enters a malaria-prone area.

Country of origin

INDIA

Manufacturer/Marketer address

Alniche Life Sciences Pvt. Ltd., S-14, 2nd Floor, Janta Market Rajouri Garden, New Delhi – 110 027
Other Info - DOX0286

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