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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Doxulip 20Mg Inj * is an anti-cancer medicine used to treat cancer. It contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs; this causes double-helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, it treats cancer.

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Synonym :

DOXORUBICIN HYDROCHLORIDE

Composition :

DOXORUBICIN-200MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Doxulip 20Mg Inj *

Doxulip 20Mg Inj * is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Doxulip 20Mg Inj * is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Doxulip 20Mg Inj * contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Doxulip 20Mg Inj * may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Doxulip 20Mg Inj *. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Doxulip 20Mg Inj * should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Doxulip 20Mg Inj * is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Doxulip 20Mg Inj *

Treatment of Breast Cancer

Directions for Use

A trained healthcare professional will administer Doxulip 20Mg Inj *. Hence, do not self-administer.

Medicinal Benefits

Doxulip 20Mg Inj * contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Doxulip 20Mg Inj * is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma.

How Doxulip 20Mg Inj * Works

Doxulip 20Mg Inj * contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Doxulip 20Mg Inj *

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discolouration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain

What if I have taken an overdose of Doxulip 20Mg Inj *

Since Doxulip 20Mg Inj * is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Doxulip 20Mg Inj * may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

Doxulip 20Mg Inj * should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Doxulip 20Mg Inj * is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Doxulip 20Mg Inj * without a doctor’s advice, as it can cause serious health conditions. Doxulip 20Mg Inj * is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
DoxorubicinAmiodarone
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Doxulip 20Mg Inj *:
Coadministration of Doxulip 20Mg Inj * with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Doxulip 20Mg Inj * is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinAmiodarone
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Coadministration of Doxulip 20Mg Inj * with amiodarone may increase the risk of abnormal cardiac rhythms.

How to manage the interaction:
Although taking Doxulip 20Mg Inj * with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor . Do not stop taking any medications without visiting a doctor.
DoxorubicinChloroquine
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Using chloroquine together with doxurubicin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Doxulip 20Mg Inj * together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinInfliximab
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Combining Infliximab with Doxulip 20Mg Inj * can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Doxulip 20Mg Inj * can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinThalidomide
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Taking thalidomide together with Doxulip 20Mg Inj * may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Doxulip 20Mg Inj * together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DoxorubicinNilotinib
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Coadministration of Doxulip 20Mg Inj * and Nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxulip 20Mg Inj * and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxorubicinEscitalopram
Severe
How does the drug interact with Doxulip 20Mg Inj *:
When Doxulip 20Mg Inj * is taken with Escitalopram, the amount of Doxulip 20Mg Inj * in the blood can go up.

How to manage the interaction:
There may be a possibility of interaction between Escitalopram and Doxulip 20Mg Inj *, but it can be taken if prescribed by a doctor. This can make the side effects of Doxulip 20Mg Inj * worse. If you notice any of these symptoms - feeling dizzy, lightheaded, or faint, having a fast or irregular heartbeat, feeling short of breath, or having prolonged diarrhea or vomiting - contact your doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinBaricitinib
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Using baricitinib together with Doxulip 20Mg Inj * may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Doxulip 20Mg Inj * if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DoxorubicinAmisulpride
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Using Amisulpride together with Doxulip 20Mg Inj * can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Doxulip 20Mg Inj * and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinEfavirenz
Severe
How does the drug interact with Doxulip 20Mg Inj *:
Taking Efavirenz and Doxulip 20Mg Inj * can increase the risk or severity of irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Doxulip 20Mg Inj * together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Doxulip 20Mg Inj * Substitute

Substitutes safety advice
  • Doxoruba 10 mg Injection 5 ml

    39.06per tablet
  • Doxoruba 50 mg Injection 25 ml

    39.20per tablet
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Doxulip 20Mg Inj * is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Doxulip 20Mg Inj *. Use reliable methods of birth control while on treatment with Doxulip 20Mg Inj *.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Doxulip 20Mg Inj *. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Doxulip 20Mg Inj * may cause dizziness and tiredness; therefore, avoid driving vehicles or operating machinery until you return to normal.

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Liver

Caution

Doxulip 20Mg Inj * should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Consult your doctor

Doxulip 20Mg Inj * is used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children). Your doctor may recommend a suitable dosage based on your child's condition.

FAQs

Doxulip 20Mg Inj * is used to treat Breast Cancer.
Doxulip 20Mg Inj * contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.
Doxulip 20Mg Inj * can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Doxulip 20Mg Inj *.
Yes, Doxulip 20Mg Inj * is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.
The common side effects of Doxulip 20Mg Inj * may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhoea, and pain at the injection site. Most of these side effects are mild and temporary, and they often resolve on their own over time. However, if you experience persistent, severe, or worsening side effects, it's crucial to consult your doctor.
It is not recommended for use in breastfeeding women as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before prescribing Doxulip 20Mg Inj *.
Doxulip 20Mg Inj * is an anti-cancer medication used to treat various types of cancer. It belongs to the class of anthracycline topoisomerase inhibitors.
Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended during the treatment.

Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - DOX0097

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