Doxoll-400 Plus Tablet is a respiratory combination medication primarily used to treat cough associated with respiratory disorders like asthma and chronic obstructive pulmonary disease (COPD). Asthma is a breathing problem in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). Cough occurs as a reflex action in the throat when mucus or any other foreign irritant is in it.

The Doxoll-400 Plus Tablet consists of two medicines: Doxofylline (antibiotic) and Ambroxol (dilutes viscous cough). Doxofylline comes into the category of bronchodilators that relax the muscles of the airways and can widen up and breathe easily. On the other hand, Ambroxol is an 'expectorant' (promotes the secretion of sputum/cough) and a 'mucolytic agent' (makes sputum less viscous) to make breathing easier in asthma and COPD patients who have difficulty in breathing.

Take Doxoll-400 Plus Tablet preferably with food to avoid stomach upset and swallow whole with a glass of water. Do not crush, chew, or break it. Your doctor will recommend how often you take Doxoll-400 Plus Tablet based on your medical condition. Some people may experience nausea, taste change, stomach pain, photosensitivity, and numbness in the mouth, tongue, and throat. Most of these side effects of Doxoll-400 Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before using Doxoll-400 Plus Tablet tell your doctor if you ever had an allergy to Doxoll-400 Plus Tablet have kidney problems, liver problems, swollen food pipe (oesophagitis), lupus disease (an autoimmune disease), muscle disease (myasthenia gravis). Please do not drink alcohol with Doxoll-400 Plus Tablet as it may increase unpleasant side effects like drowsiness and dizziness. Doxoll-400 Plus Tablet is pregnancy category D (high risk) medicines, so its use in pregnant and nursing mothers is not recommended. Use of Doxoll-400 Plus Tablet during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). Its use should be avoided by pregnant women, breastfeeding mothers, and children below 8 years of age. Do not consume alcohol as it may cause excessive drowsiness when taken along with Doxoll-400 Plus Tablet .
 

Doxoll-400 Plus Tablet is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Doxoll-400 Plus Tablet is a combination of two medicines: Doxofylline and Ambroxol. Doxofylline (also known as Doxophylline) belongs to the class of bronchodilators. It works by relaxing muscles and widening the airways of the lungs. It minimizes the lung's airflow obstruction, relieving chest tightness, wheezing, and cough to make breathing easier. While  Ambroxol works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Doxoll-400 Plus Tablet breakdown the acid mucopolysaccharide fibres that make the mucous (sputum) thinner and less dense/viscous, removing sputum efficiently by coughing. However, the viscosity of sputum remains low for as long as treatment is maintained.

• Nausea
• Vomiting
• Taste change
• Stomach pain
• Photosensitivity
• Palpitations
• Headache
• Insomnia
• Dizziness
• Numbness in the mouth, tongue, and throat
• Dryness of mouth or throat
• Taste changes

Let your doctor know if you have any allergic reactions to medicines. Please inform your doctor if you have any history of heart, liver, and kidney diseases. Also, tell your doctor if you have a stomach ulcer, seizure (fits), high blood pressure, and diabetes before taking Doxoll-400 Plus Tablet . Doxoll-400 Plus Tablet causes hypokalaemia (low potassium levels in the blood), therefore should be used with caution in patients with bronchospasm. Special precautions should be taken in patients with hyperthyroidism and epilepsy. Doxoll-400 Plus Tablet can cause a rise in blood glucose levels. Hence monitor your blood glucose levels if you have diabetes and inform your doctor so that the dose can be adjusted accordingly. Let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. If you unexpectedly go into early labour or premature labour (before 9 months) or threatened abortion, do not use Doxoll-400 Plus Tablet and consult a doctor.

Drug-Drug Interactions: Doxoll-400 Plus Tablet may interact with indigestion remedies (antacids), supplements that contain aluminium, bismuth, calcium, magnesium or zinc, stomach ulcer medicines that contain bismuth, iron supplements, other antibiotics (rifampicin), acne medicines that contain vitamin A, such as isotretinoin, a blood thinner called warfarin, medicines for epilepsy, such as phenytoin or carbamazepine, and ciclosporin, a medicine to damp down your immune system.

Drug-Food Interactions: Limit alcohol intake since it may cause a rise in blood pressure leading to heart diseases. Avoid fatty foods and control your cholesterol and triglyceride levels.

Drug-Disease Interactions: Doxoll-400 Plus Tablet is contraindicated in patients with heart, liver, kidney, and lung diseases, neuropsychiatric disorders like seizures (fits) and depression, phenylketonuria (congenital disability caused by the build-up of an amino acid called phenylalanine in the body), hyperthyroidism (overactive thyroid), high blood pressure, hypoxemia (low oxygen levels in the blood), stomach ulcers, and viral infections.

• PHENYTOIN
• RIFAMPICIN
• CICLOSPORIN
• CARBAMAZEPINE
• WARFARIN
• ISOTRETINOIN
• VITAMIN A
• CALCIUM
• ZINC

• Take Doxoll-400 Plus Tablet as directed by the doctor and at regular intervals. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Doxoll-400 Plus Tablet .
• Know your triggers like allergens, such as pollen, dust, and food items that make your asthma severe.
• Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
• Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
• Learning breathing exercises will help you move more air in and out of your lungs.
• Drink warm fluids while you take Doxoll-400 Plus Tablet to help loosen congestion and lubricate the throat.

• It is advised to inform your doctor beforehand if you are using Doxoll-400 Plus Tablet and are advised to undergo any blood examinations since Doxoll-400 Plus Tablet may cause eosinophilia (increased white blood cell count).  
• It is advised to consult a Psychiatrist if you notice any mood changes like suicidal thoughts, aggressive behaviour, anxiety, depression, abnormal dreams, and hallucinations while using Doxoll-400 Plus Tablet . 

Asthma: It is a breathing problem in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. Due to this, a whistling sound is produced during normal breathing. Symptoms of asthma include coughing, wheezing, and chest tightness.

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases that block airflow and make it difficult to breathe. The most common conditions that makeup COPD are emphysema and chronic bronchitis. The main cause of COPD is tobacco chewing or smoking for a longer duration, which exposes the lungs to chemical irritants resulting in COPD.