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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Doxific Injection is an antibiotic medicine used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections, and periodontitis. This medicine contains doxycycline which works by inhibiting the protein synthesis of the bacterial cell and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea.
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Composition :

DOXYCYCLINE-100MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Doxific Injection

Doxific Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxific Injection may also be used to treat or prevent anthrax.

Doxific Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Doxific Injection will be administered by a healthcare professional; do not self-administer. In some cases, Doxific Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Doxific Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Doxific Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Doxific Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Doxific Injection

Treatment of Bacterial infections

Directions for Use

Doxific Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Doxific Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

How Doxific Injection Works

Doxific Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Doxific Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

What if I have taken an overdose of Doxific Injection

Doxific Injection is administered by a healthcare professional in a hospital setting. Hence, the chances of overdose are less. Overdose can cause nausea, vomiting, diarrhea, photosensitivity (skin reaction to the sun), indigestion, loss of appetite and mild rash. Your doctor may initiate necessary treatment if an overdose is suspected.

Drug Warnings

Do not take Doxific Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Doxific Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug-Drug Interactions

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DoxycyclineIsotretinoin
Critical
DoxycyclineTretinoin
Critical

Drug-Drug Interactions

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DoxycyclineIsotretinoin
Critical
How does the drug interact with Doxific Injection:
Taking isotretinoin with Doxific Injection may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking isotretinoin and Doxific Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
DoxycyclineTretinoin
Critical
How does the drug interact with Doxific Injection:
Coadministration of Tretinoin with Doxific Injection can increase the risk of side effects like vision problems.

How to manage the interaction:
Taking Tretinoin with Doxific Injection is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineEtretinate
Critical
How does the drug interact with Doxific Injection:
Taking Doxific Injection with etretinate may increase the risk of vision problems.

How to manage the interaction:
Taking Etretinate with Doxific Injection is not recommended, but can be taken if prescribed by a doctor. However, consult a doctor if you experience headache, nausea, vomiting, and visual disturbances. Do not discontinue any medication without consulting a doctor.
DoxycyclineAcitretin
Critical
How does the drug interact with Doxific Injection:
Coadministration of Acitretin with Doxific Injection can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Acitretin with Doxific Injection together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineMagnesium lactate
Severe
How does the drug interact with Doxific Injection:
Magnesium lactate reduces the absorption and effectiveness of Doxific Injection.

How to manage the interaction:
Although taking Doxific Injection with Magnesium lactate can possibly result in an interaction, they can be taken together as advised by your doctor. It is recommended to take Doxific Injection 2 hours before or 6 hours after taking magnesium lactate. Do not stop using any medications without consulting a doctor.
DoxycyclineCalcium acetate
Severe
How does the drug interact with Doxific Injection:
Co-administration of Doxific Injection with calcium acetate can reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between calcium acetate and Doxific Injection, it can be taken together if prescribed by a doctor. It is adviced to take Doxific Injection 2 hrs before or 6 hours after taking calcium acetate. Do not stop using any medications without talking to a doctor.
DoxycyclineMipomersen
Severe
How does the drug interact with Doxific Injection:
Taking Doxific Injection with mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Doxific Injection with Mipomersen can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineAtracurium
Severe
How does the drug interact with Doxific Injection:
Co-administration of atracurium with Doxific Injection may increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Atracurium and Doxific Injection, bit it can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
DoxycyclineSodium citrate
Severe
How does the drug interact with Doxific Injection:
Coadministration of Sodium Citrate with Doxific Injection can reduce the effectiveness of Doxific Injection.

How to manage the interaction:
Although taking Sodium Citrate with Doxific Injection can possibly result in decreased efficacy, they can be taken together if prescribed by a doctor. It is advised to separate sodium citrate and Doxific Injection by three to four hours. Do not stop using any medications without consulting a doctor.
DoxycyclineAmoxicillin
Severe
How does the drug interact with Doxific Injection:
Co-administration of amoxicillin with Doxific Injection may reduce the therapeutic effect of amoxicillin.

How to manage the interaction:
Although there is a possible interaction between Amoxicillin and Doxific Injection, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Doxific Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Doxific Injection.
  • Avoid intake of alcoholic beverages with Doxific Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Doxific Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Doxific Injection Substitute

Substitutes safety advice
  • Doxy T 100 Capsule 8's

    by AYUR

    4.50per tablet
  • Minicycline Capsule 10's

    3.11per tablet
  • Codox Capsule 10's

    3.11per tablet
  • Pepdox 100 Capsule 10's

    9.45per tablet
  • Dox-100 Tablet 8's

    3.94per tablet
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Alcohol

Caution

It is not known if alcohol affects Doxific Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Doxific Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Doxific Injection in pregnant women. In some cases, taking Doxific Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Doxific Injection.

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Breast Feeding

Caution

Doxific Injection is excreted in the breast milk. However, the extent of absorption of Doxific Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Doxific Injection.

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Driving

Caution

It is not known if Doxific Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Doxific Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Doxific Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Doxific Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

FAQs

Doxific Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxific Injection may also be used to treat or prevent anthrax.
Doxific Injection stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Injection helps treat bacterial infections.
No, Doxific Injection should not be stopped even if you feel better as it is an antibiotic medication and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form and will also become difficult to treat due to antibiotic resistance.
If you are taking Doxific Injection, avoid taking antacids containing aluminium, calcium or magnesium or other drugs containing these cations; oral zinc, iron salts or bismuth preparations within 2 hours of consumption of Doxific Injection as they may affect the absorption of Doxific Injection. Avoid taking dairy products within 2 hours of taking Doxific Injection as they may also impair the absorption of Doxific Injection.
Use of Doxific Injection during tooth development (last half of pregnancy, infancy, and in children below the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.
Doxific Injection may make your skin sensitive to sunlight. So, apply sunscreen while going out and wear protective clothing and sunglasses. Avoid prolonged and unnecessary exposure to sunlight.
Doxific Injection may lower the effectiveness of hormonal contraceptives such as birth control pills, rings, patches, or injections. Consult your doctor if you have any concerns, your doctor may advise regarding other forms of contraception.
Doxific Injection does not completely prevent malaria caused by P. falciparum as Doxific Injection is given as a prophylactic regimen (protection) whenever anyone enters a malaria-prone area.

Country of origin

INDIA

Manufacturer/Marketer address

37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (INDIA)
Other Info - DOX0268

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