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  1. Home
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  3. Donep-M Forte Tablet 15's

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Donep-M Forte Tablet is used to treat Alzheimer's disease (memory loss). It contains Donepezil and Memantine, which balance the levels of chemical messengers in the brain and help transmit nerve signals. It may cause side effects such as vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Donep-M Forte Tablet 15's, Pack of 15 TABLETS
Donep-M Forte Tablet 15's, Pack of 15 TABLETS
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Composition :

DONEPEZIL-5MG + MEMANTINE-10MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Donep-M Forte Tablet

Donep-M Forte Tablet is used to treat Alzheimer's disease (memory loss). Alzheimer's disease is a progressive neurodisorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells (neurons) to die. 

Donep-M Forte Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Take Donep-M Forte Tablet as prescribed by your doctor. You are advised to take Donep-M Forte Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. Preferably, take it before just bedtime. In some cases, you may experience vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Donep-M Forte Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Donep-M Forte Tablet may cause dizziness and sleepiness. So, do not drive a car or operate any machinery that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donep-M Forte Tablet as it may cause diarrhoea. Before using Donep-M Forte Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.

Uses of Donep-M Forte Tablet

Treatment of Alzheimer's disease (memory loss).

Directions for Use

Swallow Donep-M Forte Tablet as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Donep-M Forte Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals. Donepezil is a cholinesterase inhibitor that works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.

How Donep-M Forte Tablet Works

Donep-M Forte Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor that works by preventing the breakdown of the chemical acetylcholine and improving the function of nerve cells in the brain. Memantine works by lowering the level of the chemical in the brain which is responsible for causing symptoms of Alzheimer's disease. Together, both of them balance the levels of chemical messengers in the brain and help transmit nerve signals.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Donep-M Forte Tablet

  • Vomiting
  • Loss of appetite
  • Dryness in the mouth
  • Dizziness
  • Weight loss
  • Nausea
  • Diarrhoea
  • Headache

What if I have taken an overdose of Donep-M Forte Tablet

Do not take more than the prescribed dose of Donep-M Forte Tablet as it may cause overdose. The symptoms of overdose include slow heart rate, severe dizziness, drowsiness, vomiting, sweating, weakness, trouble walking, agitation, confusion, unusual thoughts or behaviour, hallucinations, fainting, fits, shallow or weak breathing. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Donep-M Forte Tablet if you are allergic to Donep-M Forte Tablet or any of its ingredients. Donep-M Forte Tablet may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Increase the intake of fluids to keep yourself hydrated while taking Donep-M Forte Tablet as it may cause diarrhoea. Before using Donep-M Forte Tablet , inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. Take Donep-M Forte Tablet preferably just before bedtime.

Drug-Drug Interactions

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DonepezilIopamidol
Severe
DonepezilBupropion
Severe

Drug-Drug Interactions

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DonepezilIopamidol
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
The combined use of iopamidol and Donep-M Forte Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizures or head injury.

How to manage the interaction:
Taking Donep-M Forte Tablet 15's with Iopamidol together can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor if you experience any symptoms like shortness of breath, irregular heart rhythms, or problems with movement and memory. Do not stop using any medications without a doctor's advice.
DonepezilBupropion
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
Taking bupropion with Donep-M Forte Tablet 15's may increase the levels of Donep-M Forte Tablet 15's and the risk of developing seizures.

How to manage the interaction:
Co-administration of bupropion along with Donep-M Forte Tablet 15's can lead to an interaction, but it can be taken when recommended by a doctor. However, if you experience sudden dizziness, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DonepezilIohexol
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
Coadministration of Iohexol and Donep-M Forte Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Although taking Donep-M Forte Tablet 15's and Iohexol together can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
DonepezilCyclopentolate
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
Coadministration of Cyclopentolate with Donep-M Forte Tablet 15's can reduce the levels and effects of Cyclopentolate.

How to manage the interaction:
There may be a possibility of interaction between Cyclopentolate and Donep-M Forte Tablet 15's, but it can be taken when prescribed by a doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, or rapid heartbeat consult your doctor immediately. Do not stop using any medications without talking to your doctor.
DonepezilMetrizamide
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
The combined use of metrizamide and Donep-M Forte Tablet 15's can increase the risk of developing seizures. If you have a history of seizures or a head injury, contact your doctor immediately.

How to manage the interaction:
Although there is a possible interaction between Donep-M Forte Tablet 15's and Metrizamide, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
DonepezilTramadol
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
Coadministration of Donep-M Forte Tablet 15's with tramadol can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Taking Donep-M Forte Tablet 15's with tramadol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, increased heart rate, blurred vision, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DonepezilIomeprol
Severe
How does the drug interact with Donep-M Forte Tablet 15's:
Co-administration of Iomeprol and Donep-M Forte Tablet 15's can increase the risk of developing seizures. The risk increases in patients with a history of seizure or head injury.

How to manage the interaction:
Co-administration of Donep-M Forte Tablet 15's with Iomeprol can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor if you experience any symptoms like shortness of breath, irregular heart rhythms, or problems with movement and memory. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Find the humour in your daily life. Try to watch light-hearted shows to help relieve stress.

  • You can try increasing your mindfulness, by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.

  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve diarrhoea.

  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.

  • Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake. 

  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.

  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of memory loss.

Habit Forming

No

Therapeutic Class

CENTRAL NERVOUS SYSTEM AGENTS

Donep-M Forte Tablet Substitute

Substitutes safety advice

  • Donamem 10 Tablet 10's

    ₹24.93per tablet

  • Cogmentin 10 mg Tablet 15's

    by AYUR

    ₹21.03per tablet

  • Alzil-M 10 Tablet 10's

    ₹27.50per tablet

  • Larentine D-10 Tablet 10's

    by AYUR

    ₹22.23per tablet

  • Remenda-M Tablet 10's

    ₹16.63per tablet

Product Substitutes

Info icon

Donamem 10 Tablet 10's

₹249.3

MRP ₹277

Info icon

Cogmentin 10 mg Tablet 15's

₹315.5

MRP ₹350.5

Info icon

Alzil-M 10 Tablet 10's

₹275

MRP ₹305.5

Info icon

Larentine D-10 Tablet 10's

₹222.3

MRP ₹247

Info icon

Remenda-M Tablet 10's

₹166.3

MRP ₹189

Info icon

Donep M Forte Tablet 10's

₹236.3

MRP ₹262.5

Info icon

Donetine-M 10 Tablet 10's

₹152.1

MRP ₹169

Info icon

Don2mem-10 Tablet 10's

₹135

MRP ₹150

Info icon

Dope Plus 10mg Tablet 10's

₹234.5

MRP ₹260.5

Info icon

Donecept M Forte Tablet 10's

₹174.24

MRP ₹193.6

Info icon

Arizex Forte Tablet 10's

₹222.3

MRP ₹247

Info icon

Braineuron Tablet 10's

₹154.8

MRP ₹172

Info icon

Talimem 10 mg Tablet 10's

₹117

MRP ₹130

Info icon

Donect M 10 mg Tablet 10's

₹130.5

MRP ₹145

Info icon

Dzep-M Tablet 10's

₹162

MRP ₹180

Info icon

Neudonect M-10 Tablet 10's

₹189

MRP ₹210

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Alcohol

Caution

Taking alcohol, along with Donep-M Forte Tablet , may increase its drowsiness effect and cause excessive sleepiness.

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Pregnancy

Caution

Donep-M Forte Tablet is a pregnancy category C drug. It is not known whether it will harm the baby. So, take only if prescribed by a doctor.

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Breast Feeding

Caution

It is not known whether Donep-M Forte Tablet passes through breast milk or not. So, caution should be exercised if you are breastfeeding.

bannner image

Driving

Unsafe

Donep-M Forte Tablet is known to cause drowsiness, so please do not drive a car or operate any machinery which requires mental alertness.

bannner image

Liver

Caution

Donep-M Forte Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Donep-M Forte Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Caution

The safety and efficacy of Donep-M Forte Tablet in children have not been established.

FAQs

Donep-M Forte Tablet is used to treat Alzheimer's disease (memory loss), a progressive neurodisorder that affects the brain.
Donep-M Forte Tablet is a combination medication containing Donepezil and Memantine, which treat Alzheimer’s disease. Donepezil works by improving the function of nerve cells in the brain by preventing the breakdown of the chemical acetylcholine. Memantine works by lowering the level of chemicals in the brain, which is responsible for causing symptoms of Alzheimer's disease. Together, they balance the levels of chemical messengers in the brain and help transmit nerve signals.
No, it is recommended not to take Donep-M Forte Tablet before s surgery as it contains Donepezil, which is a cholinesterase inhibitor and is likely to exaggerate muscle relaxation during anaesthesia. So, please inform your doctor before surgery if you are taking Donep-M Forte Tablet as he might stop it &2 hours before undergoing surgery.
Yes, the use of Donep-M Forte Tablet can cause diarrhoea. In some cases, the patient may experience diarrhoea. So, please increase the intake of fluids to avoid dehydration. And also do not take any other medicines without speaking to a doctor.
Yes, Donep-M Forte Tablet is known to cause weight loss. So, while taking Donep-M Forte Tablet , you should constantly monitor your body weight to avoid major weight loss.
Taking Donep-M Forte Tablet in more than the recommended dose can cause unpleasant side-effects such as dizziness, tremor, agitation, convulsion, coma, nausea, vomiting, changes in heart rhythm, decreased blood pressure, and change in body fluid/salt balance.
Yes, Alzheimer's disease (memory loss) generally occurs in people who are elderly and aged. So, Donep-M Forte Tablet is safe for the elderly population, but the dose should be given by a doctor depending upon any underlining disease condition you are suffering from. Also, never self medicate.
Donep-M Forte Tablet may cause side effects like vomiting, weight loss, loss of appetite, dryness in the mouth, dizziness, nausea, diarrhoea, and headache. Most of these side effects of Donep-M Forte Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Alzheimer's disease is a progressive neurologic disorder that affects the brain. It causes the brain to shrink (atrophy) and brain cells to die. One of the very common causes of Alzheimer's disease is dementia (memory loss), which affects the person's ability to function independently.
Take Donep-M Forte Tablet preferably just before bedtime or as advised by the doctor.
Donep-M Forte Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Donep-M Forte Tablet can be taken along with my other regular medicines if advised by the doctor. Please consult the doctor before taking other medicines with Donep-M Forte Tablet to prevent any interactions/side effects.
Do not discontinue Donep-M Forte Tablet without consulting your doctor. To treat your condition effectively, keep taking Donep-M Forte Tablet for the prescribed duration.
Store Donep-M Forte Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Donep-M Forte Tablet is contraindicated if you are allergic to any of its components.
Inform your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma.
Taking more than the recommended dose of Donep-M Forte Tablet may cause an overdose. The symptoms of overdose include slow heart rate, severe dizziness, drowsiness, vomiting, sweating, weakness, trouble walking, agitation, confusion, unusual thoughts or behaviour, hallucinations, fainting, fits, and shallow or weak breathing. If you suspect the patient has taken an overdose or notice signs of overdose, please consult a doctor immediately.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - DON0096

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Author Details

Doctor imageDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206439lbl.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020690s035,021720s008,022568s005lbl.pdf
  3. https://www.drugs.com/mtm/donepezil-and-memantine.html
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