Domril O 10 mg/20 mg Capsule belongs to a group of medicines called gastrointestinal agents used to treat heartburn, indigestion, epigastric pain, gastro-oesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. Zollinger-Ellison syndrome is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production.

Domril O 10 mg/20 mg Capsule is a combination of two drugs, namely: Omeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Omeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Domril O 10 mg/20 mg Capsule helps in treating acidity.

Take Domril O 10 mg/20 mg Capsule 30-60 minutes prior to food. You are advised to take Domril O 10 mg/20 mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor if you have a history of gastrointestinal bleeding or intestinal obstruction. Consult your doctor before taking Domril O 10 mg/20 mg Capsule if you are pregnant or breastfeeding. Domril O 10 mg/20 mg Capsule may cause sleepiness, so drive only if you are alert. Domril O 10 mg/20 mg Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Domril O 10 mg/20 mg Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Domril O 10 mg/20 mg Capsule belongs to a group of medicines called gastrointestinal agents used to treat heartburn, indigestion, epigastric pain, gastro-oesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Domril O 10 mg/20 mg Capsule is a combination of two drugs, namely: Omeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Omeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Domril O 10 mg/20 mg Capsule helps in treating acidity.

• Dry mouth
• Stomach pain
• Diarrhoea
• Headache
• Flatulence

Do not take Domril O 10 mg/20 mg Capsule if you are allergic to any of its contents; if you are taking nelfinavir (anti-HIV); if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Domril O 10 mg/20 mg Capsule if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. Talk to your doctor before taking Domril O 10 mg/20 mg Capsule if you have osteoporosis as Domril O 10 mg/20 mg Capsule may increase the risk of bone fractures on long-term treatment. Consult your doctor before taking Domril O 10 mg/20 mg Capsule if you are pregnant or breastfeeding. Domril O 10 mg/20 mg Capsule may cause sleepiness, so drive only if you are alert. Domril O 10 mg/20 mg Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Domril O 10 mg/20 mg Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Drug-Drug Interactions: Domril O 10 mg/20 mg Capsule may interact with painkillers (aspirin), antibiotics (ciprofloxacin), statin (atorvastatin), anti-HIV (atazanavir), blood thinner (clopidogrel, warfarin, cilostazol), a drug used to treat hypothyroidism (levothyroxine), anti-fungal (ketoconazole, itraconazole, voriconazole), anti-cancer (erlotinib, methotrexate), anti-depressant (citalopram, escitalopram, duloxetine), anti-anxiety (alprazolam), vitamin (cyanocobalamin), anti-convulsant (phenytoin), gastroprokinetic agent (cisapride), cardiac glycoside (digoxin), immunosuppressant (tacrolimus), anti-tuberculosis (rifampicin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interaction: Inform your doctor if you have epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).

• ASPIRIN
• CIPROFLOXACIN
• ATORVASTATIN
• KETOCONAZOLE
• ITRACONAZOLE
• VORICONAZOLE
• ERLOTINIB
• METHOTREXATE
• CITALOPRAM
• ESCITALOPRAM
• DULOXETINE
• ALPRAZOLAM
• CYANOCOBALAMIN
• PHENYTOIN
• CISAPRIDE
• DIGOXIN
• TACROLIMUS
• RIFAMPICIN

• Eat smaller meals more often.

• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

• Maintain a healthy weight by regular exercising.

• Avoid lying down after eating as it causes acid reflux.

• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.

• Practise relaxation techniques and avoid stress by doing yoga or meditation.

• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 

• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

• Inform your doctor before taking Domril O 10 mg/20 mg Capsule if you are due to have Chromogranin A test.

• Domril O 10 mg/20 mg Capsule may cause changes in a blood test to check liver functioning. Inform the person doing the tests that you are taking Domril O 10 mg/20 mg Capsule.

• Talk to your doctor before taking Domril O 10 mg/20 mg Capsule if you have osteoporosis as Domril O 10 mg/20 mg Capsule may increase the risk of bone fractures on long-term treatment.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.

Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion

Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.