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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Domi Up Spray is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment or surgery. It contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. It may cause side effects such as feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ONDANSETRON-2MG

Manufacturer/Marketer :

Lincoln Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Domi Up Spray

Domi Up Spray belongs to a group of medications called ' anti-emetics' primarily used in the prevention of vomiting (being sick) and nausea (feeling sick) that usually occur after cancer chemotherapy, radiation treatment or surgery. Nausea is an uneasy feeling in which a person feels an urge to vomit while vomiting is the natural response to the body to forcefully discharge the stomach contents.

Domi Up Spray contains 'Ondanestron' that works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Take Domi Up Spray as prescribed. Your doctor will advise you on how often you take Domi Up Spray based on your medical condition. A person taking Domi Up Spray often experience side effects that include a feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Although, not every person faces the side effects of Domi Up Spray, and even some of the unpleasant effects of Domi Up Spray do not require medical attention.

The use of Domi Up Spray is restricted in persons who are allergic to any of the ingredients present in this medicine. Tell your doctor if you are facing liver, kidney, or heart disorders. Domi Up Spray should be used during pregnancy or breastfeeding after consulting a doctor. Domi Up Spray contains lactose so tell your doctor if you have an intolerance to some sugars.

Uses of Domi Up Spray

Treatment of Nausea, Vomiting.

Directions for Use

Tablet: It can be taken with or without a meal as advised by the doctor. Swallow the tablet as a whole with a glass of water. Do not break, crush or chew it. Oral disintegrating tablet/Mouth dissolving tablet (tablet MD): Check the label for directions before use. Do not handle the tablet with wet hands. Place the tablet in the mouth and allow it to dissolve. Do not swallow it as a whole.

Medicinal Benefits

Domi Up Spray belongs to a group of medications called anti-emetics used to prevent nausea and vomiting associated with conditions like cancer chemotherapy, radiotherapy, surgery, pregnancy and motion sickness in adults and children above 4 years of age. When serotonin level increases in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Domi Up Spray acts by inhibiting the release of this serotonin, thereby preventing nausea and vomiting. 

How Domi Up Spray Works

Domi Up Spray contains 'Ondanestron' that works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Domi Up Spray

  • Sensations of flushing
  • Constipation
  • Headache
  • Confusion
  • Dizziness
  • Fast heartbeat
  • Fever
  • Headache
  • Shortness of breath
  • Weakness

What if I have taken an overdose of Domi Up Spray

Do not take more than the prescribed dose of Domi Up Spray as it may cause overdose. The symptoms of overdose include sudden loss of vision for a short time, irregular heartbeat, constipation, fainting, dizziness or lightheadedness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Tell your doctor if you are dealing with an uneven heart, liver problems, or any other problem. Tell your doctor if you are taking medicine for epilepsy, cancer medicines, and abnormal heartbeats. Domi Up Spray may affect a person's ability to drive. Therefore, should avoid driving or operating any machine. People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of protein phenylalanine in the blood) should not take Domi Up Spray as it may cause serious conditions. The liver patient should not take more than 8 mg of Domi Up Spray daily. Domi Up Spray should be used during pregnancy or breastfeeding after consultation with a doctor. Taking Domi Up Spray with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
OndansetronRizatriptan
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Domi Up Spray 15ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronRizatriptan
Severe
How does the drug interact with Domi Up Spray 15ml:
When Domi Up Spray 15ml, is taken with rizatriptan it increases the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in body).

How to manage the interaction:
Although there is a possible interaction between Domi Up Spray 15ml and Rizatriptan, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking of hands and legs, incoordination, stomach cramps, nausea, vomiting, and loose stools, contact a doctor. Do not discontinue any medications without consulting a doctor.
OndansetronClozapine
Severe
How does the drug interact with Domi Up Spray 15ml:
Although it is a very rare adverse effect, taking Domi Up Spray 15ml with clozapine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with clozapine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronFluvoxamine
Severe
How does the drug interact with Domi Up Spray 15ml:
When Domi Up Spray 15ml is taken with fluvoxamine, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with fluvoxamine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronImipramine
Severe
How does the drug interact with Domi Up Spray 15ml:
Coadministration of Domi Up Spray 15ml along with imipramine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Taking Domi Up Spray 15ml along with imipramine together can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without consulting a doctor.
OndansetronVemurafenib
Severe
How does the drug interact with Domi Up Spray 15ml:
Although it is a very rare adverse effect, taking Domi Up Spray 15ml with vemurafenib increases the risk of an abnormal heart rhythm. If you're dealing with other heart illnesses or electrolyte imbalances (for example, magnesium or potassium loss likely due to serious or prolonged diarrhoea or vomiting), you may be at greater risk.

How to manage the interaction:
Although taking Domi Up Spray 15ml along with vemurafenib can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice
OndansetronDoxepin
Severe
How does the drug interact with Domi Up Spray 15ml:
When Domi Up Spray 15ml is taken with doxepin, it can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Domi Up Spray 15ml along with doxepin can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronOsimertinib
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with Osimertinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with Osimertinib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronNilotinib
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with nilotinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with nilotinib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronVandetanib
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with vandetanib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Domi Up Spray 15ml along with vandetanib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils, and low-fat dairy products will help to keep a person in good health and avoid chances of nausea and vomiting. 

  • One should avoid taking greasy or oily foods as this food triggers nausea and vomit.

  • Eat cool foods instead of hot and spicy foods.

  • Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up which has got lost due to vomiting. 

 

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Domi Up Spray Substitute

Substitutes safety advice
  • Ondem Syrup 30 ml

    1.26per tablet
  • Emeset Juicy Lemon Syrup 30 ml

    1.26per tablet
  • Vomikind Syrup 30 ml

    1.25per tablet
  • Zofer Syrup 30 ml

    by AYUR

    1.26per tablet
  • Vomikind MD 2 Tablet 10's

    4.46per tablet
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Alcohol

Unsafe

One should avoid consuming alcohol while taking Domi Up Spray as this medicine can interact with alcohol and may worsen the side effects.

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Pregnancy

Safe if prescribed

Domi Up Spray could be used during pregnancy after consulting a doctor.

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Breast Feeding

Safe if prescribed

Domi Up Spray could be used during breastfeeding after consulting a doctor.

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Driving

Caution

Domi Up Spray may cause lightheadedness in the body, so a person taking Domi Up Spray should avoid driving or operating any heavy machinery or tasks that require mental alertness.

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Liver

Safe if prescribed

In persons dealing with liver problems, the use of Domi Up Spray is allowed if prescribed by the doctor. However, in patients with severe liver problems should take a low dose of Domi Up Spray as much as possible. Do not take more than 8 mg of Domi Up Spray per day in case of liver disease.

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Kidney

Safe if prescribed

The use of Domi Up Spray is safe in patients dealing with kidney disorders. No dose adjustment is required.

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Children

Safe if prescribed

Domi Up Spray should not be given to the children below 4 years of age. The use of Domi Up Spray is safe in children above 4 years of age if prescribed by the doctor.

FAQs

Domi Up Spray is indicated in the treatment of nausea and vomiting.
Domi Up Spray works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.
Domi Up Spray may cause changes in the vision, so one should avoid driving or operating any machine that required mental alertness.
People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of protein phenylalanine in the blood) should not take Domi Up Spray as it may cause serious conditions. The liver patient should not take more than 8 mg of Domi Up Spray daily. Taking Domi Up Spray with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.
Domi Up Spray is an anti-sickness medicine that takes about 1-2 hours to show its action.
Domi Up Spray contains Ondansetron, an antiemetic drug.
Domi Up Spray is ineffective in preventing nausea associated with motion sickness.
Before taking the Domi Up Spray, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Yes, Domi Up Spray might make you feel sleepy or tired.
Domi Up Spray usually works quickly, usually within 30 minutes, but it can take up to two hours for the full effect.
Common side effects of Domi Up Spray may include warmth, constipation, headache, diarrhoea, drowsiness, and tiredness. However, not every person faces these side effects, and even some of the unpleasant effects of Domi Up Spray do not require medical attention.
Domi Up Spray was not found to be beneficial in the treatment of seasickness.
Domi Up Spray works by blocking the action of a chemical in the body (serotonin) that is responsible for causing nausea and vomiting. As a result, Domi Up Spray prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.
Yes, you can take Domi Up Spray half an hour to 1 hour before meals.
If you forget to take a dose of Domi Up Spray, take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.
Domi Up Spray may cause changes in the vision, so one should avoid driving or operating any machine that requires mental alertness.
Suppose you took more than the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Domi Up Spray may include constipation, dizziness or lightheadedness, fainting, irregular heartbeat, and sudden loss of vision for a short time. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.
No, Domi Up Spray is not a steroid. Domi Up Spray belongs to a class of drugs known as anti-emetics.
While specific dosing instructions will vary depending on your individual needs and medical history. Always follow your doctor's prescribed dosage and timing for taking these medications.
Take Domi Up Spray exactly as prescribed by the doctor. Take it at the same time daily as it will help you to remember taking the medication.
Yes, Domi Up Spray has also been prescribed during pregnancy to help with symptoms of nausea and vomiting in pregnancy.

Country of origin

INDIA

Manufacturer/Marketer address

LINCOLN HOUSE, B/h. Satyam Complex, Science City Road, Sola, Ahmedabad – 380 062., Gujarat, India,
Other Info - DOM0203

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