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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Divalrx XR-500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity. Thereby helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Divalrx XR-500 Tablet

Divalrx XR-500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Divalrx XR-500 Tablet is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divalrx XR-500 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity. Thereby helps in controlling seizures. Divalrx XR-500 Tablet increases the amount of a chemical substance called GABA, this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 

Take Divalrx XR-500 Tablet with or without food. You are advised to take Divalrx XR-500 Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Divalrx XR-500 Tablet without consulting your doctor to avoid worsening of seizures. Do not take Divalrx XR-500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Divalrx XR-500 Tablet . Consult your doctor before taking Divalrx XR-500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Divalrx XR-500 Tablet causes dizziness, and may affect thinking and motor skills. Avoid consuming alcohol along with Divalrx XR-500 Tablet as it could lead to increased dizziness. Care should be taken while giving Divalrx XR-500 Tablet to children below 2 years as there is a higher risk of liver intoxication during the first 6 months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Divalrx XR-500 Tablet

Treatment of Epilepsy, bipolar disorder, migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush the tablet/capsule.Oral solution: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.

Medicinal Benefits

Divalrx XR-500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Divalrx XR-500 Tablet is used to treat epilepsy/seizures/fits. Additionally, Divalrx XR-500 Tablet is also used to treat mood disorders and to prevent migraine headaches. Divalrx XR-500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Divalrx XR-500 Tablet treats mood disorder by increasing the amount of a chemical substance called GABA, this helps block the nerve transmission across the brain and provides a calming effect. Divalrx XR-500 Tablet prevents migraine headaches by limiting the transmission of nerve pain. Divalrx XR-500 Tablet is used alone or in combination to treat simple seizures, complex partial seizures and complex absence seizures. Divalrx XR-500 Tablet is used in combination to treat multiple seizures, such as absence seizures.

How Divalrx XR-500 Tablet Works

Divalrx XR-500 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity. Thereby helps in controlling seizures. Divalrx XR-500 Tablet increases the amount of a chemical substance called GABA, this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Divalrx XR-500 Tablet

  • Abdominal pain
  • Back pain
  • Constipation
  • Diarrhoea
  • Dizziness
  • Nausea
  • Increased appetite
  • Vomiting
  • Vision problems
  • Weight changes
  • Problems with walking or coordination

What if I have taken an overdose of Divalrx XR-500 Tablet

Do not take more than the prescribed dose of Divalrx XR-500 Tablet as it may cause overdose. The symptoms of overdose include heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Divalrx XR-500 Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Divalrx XR-500 Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendency while taking Divalrx XR-500 Tablet . Divalrx XR-500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Divalrx XR-500 Tablet without consulting your doctor to avoid worsening of seizures. Do not take Divalrx XR-500 Tablet if you are pregnant as it could cause serious birth defects. If you are of child-bearing age, use effective contraception while taking Divalrx XR-500 Tablet . Consult your doctor before taking Divalrx XR-500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Divalrx XR-500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Divalrx XR-500 Tablet as it could lead to increased dizziness. Care should be taken while giving Divalrx XR-500 Tablet to children below 2years as there is a higher risk of liver intoxication during the first 6months of treatment.

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateMeropenem
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Divalrx XR-500 Tablet:
Combining Sodium phenylbutyrate and Divalrx XR-500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Divalrx XR-500 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Meropenam and Divalrx XR-500 Tablet together can reduce the effect of Divalrx XR-500 Tablet.

How to manage the interaction:
Co-administration of Meropenam and Divalrx XR-500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Leflunomide and Divalrx XR-500 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Divalrx XR-500 Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Ketamine and Divalrx XR-500 Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Divalrx XR-500 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Divalrx XR-500 Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Divalrx XR-500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Using buprenorphine together with Divalrx XR-500 Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Divalrx XR-500 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Divalrx XR-500 Tablet:
The combined use of Ertapenem and Divalrx XR-500 Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Divalrx XR-500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Lithium with Divalrx XR-500 Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Divalrx XR-500 Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Teriflunomide and Divalrx XR-500 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Divalrx XR-500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Divalrx XR-500 Tablet:
Co-administration of Vorinostat with Divalrx XR-500 Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Divalrx XR-500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Divalrx XR-500 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Divalrx XR-500 Tablet belongs to pregnancy category D. Avoid taking Divalrx XR-500 Tablet if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Divalrx XR-500 Tablet may pass into breastmilk. Consult your doctor before taking Divalrx XR-500 Tablet if you are breastfeeding.

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Driving

Unsafe

Divalrx XR-500 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Unsafe

Divalrx XR-500 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Divalrx XR-500 Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight. Care should be taken in children below 2years as they are at a higher risk of liver toxicity.

FAQs

Divalrx XR-500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.

Divalrx XR-500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Divalrx XR-500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.

Divalrx XR-500 Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Divalrx XR-500 Tablet without consulting your doctor. To treat your condition effectually continue taking Divalrx XR-500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divalrx XR-500 Tablet , your doctor will reduce the dose gradually to avoid worsening of seizures.

Country of origin

India
Other Info - DIV0347

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