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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Oct 30, 2024 | 5:53 AM IST

Divalnus ER 500 Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity. Thereby helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Prescription drug

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Manufacturer/Marketer

URENUS PHARMACEUTICALS PVT LTD

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Divalnus ER 500 Tablet 10's

Divalnus ER 500 Tablet 10's belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Divalnus ER 500 Tablet 10's is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divalnus ER 500 Tablet 10's contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity. Thereby helps in controlling seizures. Divalnus ER 500 Tablet 10's increases the amount of a chemical substance called GABA, this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 

Take Divalnus ER 500 Tablet 10's with or without food. You are advised to take Divalnus ER 500 Tablet 10's as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Divalnus ER 500 Tablet 10's without consulting your doctor to avoid worsening of seizures. Do not take Divalnus ER 500 Tablet 10's if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Divalnus ER 500 Tablet 10's. Consult your doctor before taking Divalnus ER 500 Tablet 10's if you are breastfeeding. Avoid driving or operating machinery as Divalnus ER 500 Tablet 10's causes dizziness, and may affect thinking and motor skills. Avoid consuming alcohol along with Divalnus ER 500 Tablet 10's as it could lead to increased dizziness. Care should be taken while giving Divalnus ER 500 Tablet 10's to children below 2 years as there is a higher risk of liver intoxication during the first 6 months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Divalnus ER 500 Tablet 10's

Treatment of Epilepsy, bipolar disorder, migraine.

Medicinal Benefits

Divalnus ER 500 Tablet 10's belongs to a group of medicines called anticonvulsants or anti-epileptics. Divalnus ER 500 Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, Divalnus ER 500 Tablet 10's is also used to treat mood disorders and to prevent migraine headaches. Divalnus ER 500 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Divalnus ER 500 Tablet 10's treats mood disorder by increasing the amount of a chemical substance called GABA, this helps block the nerve transmission across the brain and provides a calming effect. Divalnus ER 500 Tablet 10's prevents migraine headaches by limiting the transmission of nerve pain. Divalnus ER 500 Tablet 10's is used alone or in combination to treat simple seizures, complex partial seizures and complex absence seizures. Divalnus ER 500 Tablet 10's is used in combination to treat multiple seizures, such as absence seizures.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush the tablet/capsule.Oral solution: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Divalnus ER 500 Tablet 10's

  • Abdominal pain
  • Back pain
  • Constipation
  • Diarrhoea
  • Dizziness
  • Nausea
  • Increased appetite
  • Vomiting
  • Vision problems
  • Weight changes
  • Problems with walking or coordination

Drug Warnings

Do not take Divalnus ER 500 Tablet 10's if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Divalnus ER 500 Tablet 10's if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendency while taking Divalnus ER 500 Tablet 10's. Divalnus ER 500 Tablet 10's may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Divalnus ER 500 Tablet 10's without consulting your doctor to avoid worsening of seizures. Do not take Divalnus ER 500 Tablet 10's if you are pregnant as it could cause serious birth defects. If you are of child-bearing age, use effective contraception while taking Divalnus ER 500 Tablet 10's. Consult your doctor before taking Divalnus ER 500 Tablet 10's if you are breastfeeding. Avoid driving or operating machinery as Divalnus ER 500 Tablet 10's causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Divalnus ER 500 Tablet 10's as it could lead to increased dizziness. Care should be taken while giving Divalnus ER 500 Tablet 10's to children below 2years as there is a higher risk of liver intoxication during the first 6months of treatment.

Drug Interactions

Drug-Drug Interactions: Divalnus ER 500 Tablet 10's may have interaction with pain killers (aspirin), anti-epileptics (pregabalin, topiramate, phenobarbital, primidone, phenytoin, carbamazepine, lamotrigine, felbamate, ethosuximide), anti-HIV (zidovudine), anti-depressant (duloxetine, escitalopram, amitriptyline, nortriptyline), anti-psychotic (aripiprazole, lurasidone, quetiapine), anti-anxiety (alprazolam), anti-TB (rifampicin), anti-coagulant (warfarin), antibiotics (imipenem, meropenem), and benzodiazepine (diazepam).

Drug-Food Interactions: Avoid alcohol consumption while taking Divalnus ER 500 Tablet 10's as it might cause increased dizziness and sleepiness. Alcohol intake might also provoke seizures.

Drug-Disease Interactions: Divalnus ER 500 Tablet 10's may interact with disease conditions such as depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease and thrombocytopenia (low levels of platelets).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Habit Forming

No

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Divalnus ER 500 Tablet 10's as it may cause thrombocytopenia (low platelet levels).

  • Divalnus ER 500 Tablet 10's may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.

  • Divalnus ER 500 Tablet 10's might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Divalnus ER 500 Tablet 10's.

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalised and partial seizures. Generalised seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Mood disorder: It is a mental health disorder which mainly affects a person's emotional state. A mood disorder is associated with episodes of mood swings ranging from manic highs to depressive lows.

Migraine: Migraine is a neurological condition which is characterized by intense headaches. Symptoms include nausea, vomiting, and sensitivity to light and sound.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Divalnus ER 500 Tablet 10's as it may cause increased dizziness.

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Pregnancy

Unsafe

Divalnus ER 500 Tablet 10's belongs to pregnancy category D. Avoid taking Divalnus ER 500 Tablet 10's if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Divalnus ER 500 Tablet 10's may pass into breastmilk. Consult your doctor before taking Divalnus ER 500 Tablet 10's if you are breastfeeding.

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Driving

Unsafe

Divalnus ER 500 Tablet 10's causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Unsafe

Divalnus ER 500 Tablet 10's should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Divalnus ER 500 Tablet 10's can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight. Care should be taken in children below 2years as they are at a higher risk of liver toxicity.

Country of origin

India

Manufacturer/Marketer address

S No 14,20,21,22,23, 101 A Block, Western Plaza, Dargah Hussain Shahwali, Hyderabad Hyderabad Tg 500008 In.
Other Info - DIV0378

Author Details

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FAQs

Divalnus ER 500 Tablet 10's is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.
Divalnus ER 500 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Divalnus ER 500 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.
Divalnus ER 500 Tablet 10's limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.
Do not discontinue Divalnus ER 500 Tablet 10's without consulting your doctor. To treat your condition effectually continue taking Divalnus ER 500 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divalnus ER 500 Tablet 10's, your doctor will reduce the dose gradually to avoid worsening of seizures.
Divalnus ER 500 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Divalnus ER 500 Tablet 10's. Avoid getting pregnant while taking Divalnus ER 500 Tablet 10's as it could lead to serious birth defects. Do not stop taking Divalnus ER 500 Tablet 10's and consult your doctor immediately if you become pregnant.
Divalnus ER 500 Tablet 10's may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Divalnus ER 500 Tablet 10's.
Topiramate (anticonvulsant) should not be taken along with Divalnus ER 500 Tablet 10's as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It's crucial to consult with your doctor before discontinuing Divalnus ER 500 Tablet 10's. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Divalnus ER 500 Tablet 10's is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Divalnus ER 500 Tablet 10's can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.
Yes, Divalnus ER 500 Tablet 10's can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Divalnus ER 500 Tablet 10's, it's essential to consult with your doctor.
Yes, Divalnus ER 500 Tablet 10's can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Divalnus ER 500 Tablet 10's, seeking medical attention is crucial.
Avoid consumption of alcohol while taking Divalnus ER 500 Tablet 10's as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Divalnus ER 500 Tablet 10's, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
Overdose of Divalnus ER 500 Tablet 10's can be a severe medical emergency. If you or someone you know has taken an overdose of Divalnus ER 500 Tablet 10's, it's crucial to seek immediate medical attention.

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