Diof Suspension is an antibiotic medicine used to treat bacterial infections in children. It is used in treating infections of the skin, throat, ear, and lungs caused by bacteria. It is also used in the treatment of dysentery (bloody stools) caused by amoeba. A bacterial infection occurs when harmful bacteria enter and grow in the body. This bacteria can infect any part of the body and multiply very quickly. Amoebic dysentery can be caused due to Entamoeba histolytica, Giardia lamblia, or Clostridium difficile.

Diof Suspension is a combination medicine containing Ofloxacin (fluoroquinolone) and Metronidazole (antimicrobials). Ofloxacin works by inhibiting the repair of the bacterial cell wall (a protective covering) and causing damage to the bacterial cell wall. This eventually leads to the death of the bacterial cell and thus prevents the growth of bacterial infections. Metronidazole kills parasites and anaerobic bacteria that are responsible for causing infections. It works by damaging their DNA.

Diof Suspension may cause certain side effects in your child such as indigestion, diarrhea, nausea, and stomach pain. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your paediatrician. Diof Suspension should be given as advised by your paediatrician. Do not give more than the prescribed dose of Diof Suspension to the child. Generally, the dose of the medicine will be decided by your paediatrician depending upon the type and severity of the infection.

Diof Suspension is intended for pediatric use only. Avoid giving Diof Suspension to your child if she/he is allergic to antibiotics. Keep your doctor informed about your child’s health condition including his current medications and medical history to rule out any side effects/interactions. Before administration, let your paediatrician know if your child has lung disease, muscle weakness, liver, and kidney disease.

Diof Suspension contains Ofloxacin and Metronidazole (antimicrobials). Both these drugs are broad-spectrum antibiotics that act against aerobic (grow in the presence of oxygen) and anaerobic (grow in the absence of oxygen) bacteria. Diof Suspension is used in the treatment of several bacterial infections and amoebic dysentry in children. Ofloxacin works by inhibiting the repair of the bacterial cell wall (a protective covering) and causing damage to the bacterial cell wall. This eventually leads to the death of the bacterial cell and thus prevents the growth of bacterial infections. Metronidazole works by damaging the DNA. This kills parasites and anaerobic bacteria that are responsible for causing infections.

• Nausea
• Diarrhea
• Stomach upset
• Indigestion
• Vomiting

Avoid giving Diof Suspension to your child if she/he is allergic to antibiotics. Keep your doctor informed about your child’s health condition including his current medications and medical history to rule out any side effects/interactions. Before administration, let your paediatrician know if your child has lung disease, muscle weakness, liver, and kidney disease. Dairy products should be avoided along with Diof Suspension.

Drug-Drug Interactions: Diof Suspension may interact with caffeine-containing medications, antacids, etc. Give Diof Suspension either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc,

Drug-Food Interactions: No interactions found/established. 

Drug-Disease Interactions: Inform your doctor before administering Diof Suspension if your child has any history of lung disease, kidney or liver disease.

• Include more fiber-enriched food in your child’s diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth.
• Fiber foods may help restore healthy gut bacteria after a course of antibiotics.
• Avoid giving too much calcium, or iron-enriched foods, as it might affect the working of Diof Suspension. 
• Make your child drink more fluids to avoid dehydration.
• Do not make your child drink or eat a lot of caffeine-containing products such as cola, or chocolate.

Bacterial infection: A bacterial infection occurs when harmful bacteria enter, grow, and infect the body. It can infect any part of the body and multiply very quickly. These infections vary from minor illnesses to severe brain infections like meningitis and encephalitis. When your child gets infected with these germs, they can experience generalized symptoms, like fevers, chills, and fatigue. Children with a weak immune system are more prone to infections.  

Amoebic dysentery: It is an intestinal infection caused by the protozoal parasite named Entamoeba histolytica. Symptoms may include fever, chills, bloody diarrhoea, and abdominal discomfort. It can also cause constipation in some children.