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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:40 PM IST
Diof DS Suspension is used to treat various infections caused by bacteria and dysentery caused due to amoeba. It contains Ofloxacin and Metronidazole, which kills the bacteria and parasites that are responsible for causing infections. In some cases, you may experience nausea, vomiting, upset of stomach, loss of appetite, dry mouth, and metallic taste. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer

Zuventus Healthcare Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Diof DS Suspension

Diof DS Suspension is a combination of antibacterial (ofloxacin) and anti-amoebic (metronidazole) used to treat various infections caused by bacteria and dysentery caused due to amoeba. A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple very quickly. Amoebic dysentery can be caused due to Entamoeba histolytica, Giardia lamblia, or Clostridium difficile.

Diof DS Suspension is a combination of two antibiotics that include Ofloxacin and Metronidazole. Ofloxacin prevents the division of bacterial cells. It also inhibits the repairing of bacterial cells. Both these actions lead to the killing of the bacteria. Metronidazole kills parasites and anaerobic bacteria that are responsible for causing infections. It works by damaging their DNA. Both are bactericidal in nature, and collectively they help in treating the disease effectively.

Take Diof DS Suspension as prescribed. Your doctor will recommend how often you take Diof DS Suspension based on your medical condition. In some cases, you may experience nausea, vomiting, upset of stomach, loss of appetite, dry mouth, and metallic taste. Metronidazole can also cause headache, dizziness, drowsiness, and confusion. Most of these side effects of Diof DS Suspension do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. If you experience any allergic reaction symptoms such as rashes, itching, swelling, shortness of breath, etc., please consult your doctor immediately.

It is not advisable to stop taking Diof DS Suspension suddenly to avoid unpleasant side effects. The full course prescribed by the doctor should be completed. Inform your doctor if you have any lung disease, epilepsy, sleeping disorder, or difficulty sleeping (sleep apnoea), severe liver disease, or problem with alcohol or other prescription recreational drugs. Diof DS Suspension should not be used by the pregnant women (especially during the first trimester), breastfeeding mother and patients with liver diseases, low blood white cells (leukopenia), seizures (fits), gastro intestine diseases (like Crohn's disease, Inflammatory bowel disease etc.) and other neurological related diseases. Do not drive or operate heavy machinery as it can lower your mental alertness and cause dizziness.

Uses of Diof DS Suspension

Treatment of Bacterial infection, Diarrhea, Dysentry, Intestinal infection.

Medicinal Benefits

Diof DS Suspension is a combination of two antibiotics that include Ofloxacin and Metronidazole. Ofloxacin prevents the division of bacterial cells. It also inhibits the repairing of bacterial cells. Both these actions lead to the killing of the bacteria. Metronidazole kills parasites and bacteria that are responsible for causing infections. It works by damaging their DNA. Both are bactericidal in nature.

Directions for Use

Tablet: Take it with or without food (excluding dairy products) as advised by the doctor. Swallow it with a glass of water. Do not break, crush or chew it.Suspension: Shake the bottle well before use. Check the label for directions and take it with or without food in doses as prescribed by the doctor with the help of a measuring cup.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Diof DS Suspension

  • Nausea
  • Vomiting
  • Upset stomach
  • Loss of appetite
  • Dry mouth
  • Metallic taste
  • Headache

Drug Warnings

If you are allergic to ofloxacin, metronidazole, or any other antibacterial or anti-amoebic agents, please inform your doctor to avoid any unwanted side effects like swallowing or breathing problems, swelling of your lips, face, throat, or tongue. Taking Diof DS Suspension may increase the chances of developing tendinitis (swelling of a tissue that joins a bone to a muscle) or a tendon rupture. Dairy products should be avoided along with Diof DS Suspension. And also, exposure to sunlight should be avoided while taking Diof DS Suspension as it may cause increased phototoxicity or photosensitivity. Patients with an irregular heartbeat (QT prolongation) should tell their doctor before taking Diof DS Suspension. Some medicines like pain killers (ibuprofen or diclofenac,) anti-asthma (theophylline), anti-diabetic (glibenclamide), anti-gout (probenecid), anti-cancer (5-fluorouracil), antidepressant (lithium), antiepileptic (phenobarbital, phenytoin), blood thinner (warfarin) should not be taken with Diof DS Suspension to avoid worsening of the condition. Diof DS Suspension should not be given to the pregnant mother (during the first trimester) and in nursing mothers as it passes into the breast milk. Please inform you, doctor, before taking Diof DS Suspension if you have a history of problems with your liver, blood, low white blood cell count (leukopenia), nervous system (convulsions). Do not drink alcohol with Diof DS Suspension as it may cause flushing and drowsiness which can alter your mental alertness.

Drug Interactions

Drug-drug interaction: This medicine may have an interaction with pain killers (ibuprofen or diclofenac,) anti-asthma (theophylline), anti-diabetic (glibenclamide), anti-gout (probenecid), anti-cancer (5-fluorouracil), antidepressant (lithium), antiepileptic (phenobarbital, phenytoin), and blood thinner (warfarin).

Drug-Food Interaction:  Diof DS Suspension interacts with dairy products (like milk or yoghurt) or calcium-fortified juices alone.

Drug-Disease Interaction: Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder (rheumatoid arthritis), seizures (fits), low white blood cell count (leukopenia), epilepsy or if you participate in regular physical activity before starting Diof DS Suspension.

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • DICLOFENAC
  • THEOPHYLLINE
  • GLIBENCLAMIDE
  • PROBENECID
  • LITHIUM
  • PHENOBARBITAL
  • PHENYTOIN
  • WARFARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Diof DS Suspension may increase nervousness, sleeplessness, and anxiety caused by caffeine.
  • Probiotics should be taken after taking the full course of Diof DS Suspension in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
  • Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking Diof DS Suspension.
  • Avoid intake of alcoholic beverages with Diof DS Suspension as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Diof DS Suspension in fighting off infections.

Special Advise

You should consult a doctor if you have symptoms associated with dehydration like dry mouth, excessive thirst, wrinkled skin, little or no urination, dizziness and lightheadedness.

Disease/Condition Glossary

Bacterial Infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly of spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. People with weak immune systems or taking immunosuppressive medicine can make them more prone to bacterial infection.

Diarrhoea: It is the increase in bowel movement leading to increased and loose motions. 

Dysentery: It is inflammation of the intestine, particularly the colon, caused by the bacteria Shigella.

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Alcohol

Unsafe

Alcohol should not be consumed while taking Diof DS Suspension to avoid unpleasant side-effects like flushing, lightheadedness, dizzy and drowsy.

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Pregnancy

Unsafe

Diof DS Suspension should not be taken if you are pregnant or planning to have a baby. If you become pregnant while taking Diof DS Suspension, stop taking the medication, and contact your doctor immediately. Metronidazole should not be given in the first trimester of the pregnancy as it may cause harm to the fetus.

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Breast Feeding

Caution

Diof DS Suspension passes in the breast milk so the nursing mother should avoid taking Diof DS Suspension.

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Driving

Caution

Diof DS Suspension can cause dizziness in some patients. If you feel dizzy, please do not operate the car.

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Liver

Caution

Diof DS Suspension to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Diof DS Suspension to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Diof DS Suspension can be given to the children for typhoid fever, diarrhoea, stomach infection, amoebiasis, abdominal infection, diarrhoea and intestinal infection.

Country of origin

India

Manufacturer/Marketer address

Office No. 5119, 5th Floor, 'D' Wing, Oberoi Garden Estates, Chandivili, Andheri (E), Mumbai - 400 072
Other Info - DIO0012

Author Details

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FAQs

Diof DS Suspension is used to treat various infections caused by bacteria and dysentery caused due to amoeba.
It is not advised to take alcohol with Diof DS Suspension. Taking alcohol while taking Diof DS Suspension can cause serious side effects such as headaches, feeling or being sick, pain in the stomach, hot flushes, a fast or irregular heartbeat, dizziness, drowsiness, etc.
Diof DS Suspension makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.
If you miss a dose of Diof DS Suspension, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
No. Diof DS Suspension is an antibacterial medicine that acts only against bacterial infections and not against viral infections . You should not take Diof DS Suspension without prior consulting your doctor. Self-medication is dangerous and can lower the efficacy of Diof DS Suspension, leading to antibiotic resistance.
Yes, intake of Diof DS Suspension may cause dry mouth and you might be feeling thirsty frequently. Try to drink plenty of fluids (water with electrolytes) and probiotics. You may also have a dry lip for which you can use lip balm.
Avoid intake of Diof DS Suspension if you have a history of problems with your liver, blood or nervous system (convulsions or fits), low white blood cell count (leukopenia).

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