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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Last Updated Oct 9, 2024 | 12:36 PM IST
Difclin 100mg Injection is an antibiotic medicine used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections, and periodontitis. This medicine contains doxycycline which works by inhibiting the protein synthesis of the bacterial cell and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea.
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Manufacturer/Marketer

Baxton Pharmacia Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Difclin 100mg Injection

Difclin 100mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Difclin 100mg Injection may also be used to treat or prevent anthrax.

Difclin 100mg Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Difclin 100mg Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Difclin 100mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Difclin 100mg Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Difclin 100mg Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Difclin 100mg Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Difclin 100mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Difclin 100mg Injection

Treatment of Bacterial infections

Medicinal Benefits

Difclin 100mg Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

Directions for Use

Difclin 100mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Difclin 100mg Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

Drug Warnings

Do not take Difclin 100mg Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Difclin 100mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug Interactions

Drug-Drug Interactions: Difclin 100mg Injection may interact with retinoid medications taken by mouth (acitretin, isotretinoin), blood thinners (warfarin), heart disease medicine (digoxin), anti-seizure medications (phenytoin, carbamazepine), antacids containing aluminium, calcium, or magnesium, bismuth subsalicylate, iron supplements, and oral birth control pills. 

Drug-Food Interactions: Food containing calcium and iron should be avoided within 2 hours of Difclin 100mg Injection as it may affect Difclin 100mg Injection effectiveness.

Drug-Disease Interactions: Inform your doctor if you have kidney problems, liver problems, swollen food pipe (esophagitis), lupus disease (an autoimmune disease), or muscle disease (myasthenia gravis).

Drug-Drug Interactions Checker List

  • ACITRETIN
  • ISOTRETINOIN
  • WARFARIN
  • DIGOXIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • ALUMINIUM
  • CALCIUM
  • MAGNESIUM
  • BISMUTH SUBSALICYLATE

Habit Forming

No

Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Difclin 100mg Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Difclin 100mg Injection.
  • Avoid intake of alcoholic beverages with Difclin 100mg Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Difclin 100mg Injection in fighting off infections.

Special Advise

  • Wear sunglasses and sunscreen when you go out in the sun as Difclin 100mg Injection can make your skin sensitive to light.
  • Maintain a gap of 2 hours between Difclin 100mg Injection and iron supplements and antacids as taking them together might affect the working of Difclin 100mg Injection.
  • Difclin 100mg Injection might affect certain lab tests, inform the person doing the tests that you are taking Difclin 100mg Injection.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

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Alcohol

Caution

It is not known if alcohol affects Difclin 100mg Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Difclin 100mg Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Difclin 100mg Injection in pregnant women. In some cases, taking Difclin 100mg Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Difclin 100mg Injection.

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Breast Feeding

Caution

Difclin 100mg Injection is excreted in the breast milk. However, the extent of absorption of Difclin 100mg Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Difclin 100mg Injection.

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Driving

Caution

It is not known if Difclin 100mg Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Difclin 100mg Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Difclin 100mg Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Difclin 100mg Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

Country of origin

India

Manufacturer/Marketer address

1St Floor, C-3, Scf 1013, New Motor Market, Manimajra, Chandigarh, 160101
Other Info - DIF0042

Author Details

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FAQs

Difclin 100mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Difclin 100mg Injection may also be used to treat or prevent anthrax.
Difclin 100mg Injection stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Difclin 100mg Injection helps treat bacterial infections.
No, Difclin 100mg Injection should not be stopped even if you feel better as it is an antibiotic medication and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form and will also become difficult to treat due to antibiotic resistance.
If you are taking Difclin 100mg Injection, avoid taking antacids containing aluminium, calcium or magnesium or other drugs containing these cations; oral zinc, iron salts or bismuth preparations within 2 hours of consumption of Difclin 100mg Injection as they may affect the absorption of Difclin 100mg Injection. Avoid taking dairy products within 2 hours of taking Difclin 100mg Injection as they may also impair the absorption of Difclin 100mg Injection.
Use of Difclin 100mg Injection during tooth development (last half of pregnancy, infancy, and in children below the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.
Difclin 100mg Injection may make your skin sensitive to sunlight. So, apply sunscreen while going out and wear protective clothing and sunglasses. Avoid prolonged and unnecessary exposure to sunlight.
Difclin 100mg Injection may lower the effectiveness of hormonal contraceptives such as birth control pills, rings, patches, or injections. Consult your doctor if you have any concerns, your doctor may advise regarding other forms of contraception.
Difclin 100mg Injection does not completely prevent malaria caused by P. falciparum as Difclin 100mg Injection is given as a prophylactic regimen (protection) whenever anyone enters a malaria-prone area.

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