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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dessin Nasal Spray is an antidiuretic medicine. It is used as replacement therapy in central cranial diabetes insipidus. It is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma. Some of the common side effects include weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing.

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Consume Type :

NASAL

Return Policy :

Not Returnable

About Dessin Nasal Spray

Dessin Nasal Spray belongs to the class of 'antidiuretics', primarily used as replacement therapy in central cranial diabetes insipidus, a condition in which the body fails to control water balance, resulting in excessive urination. Dessin Nasal Spray is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma or surgery in the pituitary gland.

Dessin Nasal Spray contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, Dessin Nasal Spray is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration. 

Dessin Nasal Spray is for intranasal use only. Your doctor will decide the dosage depending on your medical condition. The common side effects of Dessin Nasal Spray include conjunctivitis/red eyes, weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing (sense of warmth) of the face. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting Dessin Nasal Spray, let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart problems/failure, swelling or scarring of the nasal lining, and illnesses that cause fluid/mineral imbalance. While using Dessin Nasal Spray, avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Pregnant and breastfeeding women should consult their doctor before using Dessin Nasal Spray. 

Uses of Dessin Nasal Spray

Dessin Nasal Spray is used in the treatment of central cranial diabetes insipidus, polyuria, and polydipsia

Directions for Use

Intranasal solution/Nasal spray: Read the instruction leaflet (if provided) carefully before using and prime the nozzle, if required. Blow your nose. Tilt your head back and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. When pressing down the pump, apply even pressure and press down quickly to produce a consistent spray. Repeat the same process for another nostril if required. Wipe off the tip with a clean tissue and replace the cap.Nasal drops: Read the instruction leaflet (if provided) carefully and use it as suggested by the doctor. Insert the tip of the dropper into the end of the medicine dispensing tube marked with measurements. Squeeze the dropper until the solution has reached the desired measurement. You can also use a syringe to fill the tube. Hold the tip of the tube, gently insert it into one nostril, and put the other end of the tube into your mouth. Hold your breath, tilt back your head, and blow slowly through your mouth into the tube so the solution reaches your nose.

Medicinal Benefits

Dessin Nasal Spray is a hormone analogue that contains Desmopressin, a synthetic form of Vasopressin (an antidiuretic hormone that controls fluid balance). Dessin Nasal Spray mimics the natural hormone vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination. Dessin Nasal Spray is not indicated for the treatment of nephrogenic diabetes insipidus.

How Dessin Nasal Spray Works

Dessin Nasal Spray contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, Dessin Nasal Spray is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dessin Nasal Spray

  • Conjunctivitis/red eyes
  • Weakness
  • Headache
  • Nose bleeds
  • Nasal congestion/stuffy nose
  • Rhinitis/runny nose
  • Nausea
  • Upset stomach
  • Abdominal pain
  • Flushing of the face 

What if I have taken an overdose of Dessin Nasal Spray

Avoid taking more than the prescribed dose of Dessin Nasal Spray as it can cause serious side effects. Overdose of Dessin Nasal Spray include hyponatremia (low levels od sodium levels in the blood). Seek immediate medical attention if you observe any of these side effects.

Drug Warnings

Before starting Dessin Nasal Spray, let your doctor know if you have any history of allergic reactions to antidiuretic hormones, severe kidney disease, hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart failure, illnesses that cause fluid/mineral imbalance (cystic fibrosis), and fluid retention. Please consult your doctor before starting Dessin Nasal Spray if you are pregnant, planning to conceive or are a breastfeeding mother. Alcohol consumption may interfere with the working of Dessin Nasal Spray; hence it is advised to limit or avoid its intake. Dessin Nasal Spray should be used in children only when prescribed by the doctor.

Drug-Drug Interactions

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DesmopressinPrednisone
Critical
DesmopressinBetamethasone
Critical

Drug-Drug Interactions

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DesmopressinPrednisone
Critical
How does the drug interact with Dessin Nasal Spray:
Coadministration of Prednisone and Dessin Nasal Spray may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Dessin Nasal Spray and prednisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBetamethasone
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Dessin Nasal Spray with Betamethasone can increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Betamethasone and Dessin Nasal Spray can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, and/or sudden weight gain, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DesmopressinFluticasone Propionate
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Dessin Nasal Spray together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
Coadministration of Dessin Nasal Spray and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinPrednisolone
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Prednisolone and Dessin Nasal Spray may increase the risk of hyponatremia (low levels of sodium in the blood).

How to manage the interaction:
Taking Prednisolone with Dessin Nasal Spray is not generally advised as they lead to an interaction, they can be taken together if advised by a doctor. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DesmopressinTriamcinolone
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Dessin Nasal Spray together with triamcinolone may increase the risk of hyponatremia (a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Triamcinolone with Dessin Nasal Spray is not recommended, but it should be taken if advised by a doctor. However, if you experience nausea, vomiting, headache, tiredness, irritability, difficulty concentrating, confusion, muscle spasm, weakness, , decreased urination and loss of appetite(less desire to eat), contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinFluticasone furoate
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Dessin Nasal Spray together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
If you have to use Dessin Nasal Spray and Fluticasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBumetanide
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Bumetanide and Dessin Nasal Spray may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Dessin Nasal Spray and Bumetanide together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinCiclesonide
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Bumetanide and Dessin Nasal Spray may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Dessin Nasal Spray and Ciclesonide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinDexamethasone
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Dessin Nasal Spray with Dexamethasone may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Dexamethasone and Dessin Nasal Spray can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DesmopressinDeflazacort
Critical
How does the drug interact with Dessin Nasal Spray:
Co-administration of Deflazacort and Dessin Nasal Spray may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
  • Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
  • Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
  • Optimal water intake is recommended to prevent dehydration due to excessive urination.

Habit Forming

No

Therapeutic Class

HORMONES
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Alcohol

Caution

Alcohol consumption may interfere with the working of Dessin Nasal Spray; hence it is advised to limit or avoid its intake.

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Pregnancy

Caution

Dessin Nasal Spray should be used in pregnancy only when recommended by a doctor. Please consult your doctor before starting Dessin Nasal Spray if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Dessin Nasal Spray is excreted into the breast milk when used by a breastfeeding mother. Please seek medical advice before you start Dessin Nasal Spray if you are nursing.

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Driving

Safe if prescribed

Dessin Nasal Spray usually does not interfere with your driving ability. Do not drive or operate machinery if you experience unmanageable side effects with Dessin Nasal Spray.

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Liver

Caution

Please let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Dessin Nasal Spray.

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Kidney

Caution

Dessin Nasal Spray is contraindicated in patients with moderate to severe renal impairment. Please let your doctor know if you have any history of kidney diseases when prescribed Dessin Nasal Spray.

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Children

Caution

Dessin Nasal Spray should be used in children only when prescribed by the doctor.

FAQs

Dessin Nasal Spray is an antidiuretic medicine used as replacement therapy in central cranial diabetes insipidus. It is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma.
Dessin Nasal Spray contains Desmopressin, a human-made form of vasopressin (antidiuretic hormone). When your body cannot produce enough vasopressin, Dessin Nasal Spray is used to replace it. It helps treat cranial diabetes insipidus, polyuria, and polydipsia.
Do not use Dessin Nasal Spray if you have polyuria that has not been diagnosed as diabetes insipidus. It is advised to use the Dessin Nasal Spray only when the doctor has suggested it for you, depending on your medical condition.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.
Optimal intake of fluids is recommended to prevent dehydration. However, avoid excess intake of water and other liquids like coffee, tea, cola, and energy drinks during the treatment. Excessive fluid intake while using Dessin Nasal Spray may lead to a build-up of water, which dilutes the salt in the body leading to serious problems.

Country of origin

India

Manufacturer/Marketer address

Plot No. 24,Road No. 7,Shaktinagar, L.B. Nagar,Hyderabad-500 074,Andhra Pradesh,India
Other Info - DE24780

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