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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Defza 1 mg Tablet is used to treat Duchene muscular dystrophy in adults and children above 2 years of age. It contains Deflazacort, which binds to immune cells, resulting in the inhibition of inflammation and autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. It makes organ transplantation possible and treats muscle disorders like Duchenne muscular dystrophy. Some people may experience side effects such as nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhoea and fast heartbeats. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DEFLAZACORT-1MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Defza 1 mg Tablet

Defza 1 mg Tablet is used to treat Duchene muscular dystrophy in adults and children above 2 years of age. Autoimmune disease is a health disorder in which the immune system doesn't work normally & is unable to distinguish between a foreign cell & a native cell. This condition results in an immune system that starts to attack native cells & organs, leading to medical problems like Duchenne muscular dystrophy.

Defza 1 mg Tablet is an immunosuppressive drug that works by binding to immune system cells and turns off the receptors that lead to their abnormal functioning or damaging effects. Defza 1 mg Tablet binds to immune cells, resulting in the inhibition of inflammation & autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. Thus, a Defza 1 mg Tablet class of drugs is beneficial in autoimmune diseases and inflammation that causes harm in various organs, especially in joints in arthritis & skin psoriasis. Defza 1 mg Tablet makes organ transplantation possible & treats muscle disorders like Duchenne muscular dystrophy.

Defza 1 mg Tablet is available in both oral tablet and suspension dosage forms. The tablet form of Defza 1 mg Tablet can be taken with or without food and swallowed whole with a water glass. Do not crush, chew or break it. The liquid form of Defza 1 mg Tablet can be taken as advised by your doctor with a measuring cup. Your doctor will recommend how often you take Defza 1 mg Tablet based on your medical condition. Some people may experience nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhoea and fast heartbeats. Most of these side effects of Defza 1 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Do not quit taking deflazacort without consulting your physician. Symptoms such as loss of appetite, a disturbed stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss may be caused by stopping the medication suddenly.

Before starting Defza 1 mg Tablet, please inform your doctor that you are allergic (hypersensitive) to Defza 1 mg Tablet. Extra care is to be taken when a patient has an already existing infection being treated (systemic infection) or has recently had some live virus vaccines. Doctors' consultation is required as Defza 1 mg Tablet is not safe to use during pregnancy.

Uses of Defza 1 mg Tablet

Treatment of Duchenne muscular dystrophy (DMD).

Directions for Use

Swallow this tablet whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the course. Do not chew or crush it. If you cannot swallow the tablet as a whole, you may break the pill into half and take both halves one at a time.

Medicinal Benefits

Defza 1 mg Tablet is beneficial in inflammatory diseases, including asthma, arthritis, and allergies. It is used in the treatment of Duchenne muscular dystrophy (DMD). It raises the amount of glucocorticoid in the body. It works by reducing the formation of inflammatory substances and suppressing immunity to prevent self-damage caused by the immune system (auto-immune reactions occurring in organ transplants, autoimmune diseases, or cancer). Defza 1 mg Tablet is a steroid that interacts with overactive immune cells, slows their activity, and decreases the damaging effects they cause in the body. 

How Defza 1 mg Tablet Works

Defza 1 mg Tablet is an immunosuppressive drug that works by binding to immune system cells and turns off the receptors that lead to their abnormal functioning or damaging effects. Defza 1 mg Tablet binds to immune cells, resulting in the inhibition of inflammation & autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. Thus, a Defza 1 mg Tablet class of drugs is beneficial in autoimmune diseases and inflammation that causes harm in various organs, especially in joints in arthritis & skin psoriasis. Defza 1 mg Tablet makes organ transplantation possible & treats muscle disorders like Duchenne muscular dystrophy.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Defza 1 mg Tablet

Most of the side effects of Defza 1 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Common side effects include upper respiratory tract infection, excessive abdominal fat, runny or stuffy nose, skin redness, irritability, abdominal discomfort or pain, irregular behaviour, fever, back pain, acne, nausea, restlessness, nosebleeds and stretch marks.

What if I have taken an overdose of Defza 1 mg Tablet

Do not take more than the prescribed dose of Defza 1 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Patients with a history of tuberculosis (TB), heart disease or heart failure stomach disorders (gastritis, peptic ulcer), diabetes (including family history), osteoporosis (bone disease), myasthenia gravis (muscle weakness), depression, mental distress, history of muscular problems caused by corticosteroids, kidney & liver dysfunction (including hepatic insufficiency and cirrhosis), should consult a doctor before using Defza 1 mg Tablet.  This medicine is not recommended for children less than 5 years of age, lactating mothers and pregnant women. Avoid going near people who are sick or infected while using Defza 1 mg Tablet. Before taking Defza 1 mg Tablet for at least, 4-6 weeks do not take any live vaccine as it may cause severe allergic reactions. 

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
DeflazacortTelaprevir
Severe

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
How does the drug interact with Defza 1 mg Tablet 6's:
Co-administration of Defza 1 mg Tablet 6's and Desmopressin may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DeflazacortTelaprevir
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Coadministration of Telaprevir with Defza 1 mg Tablet 6's can increase the levels of Defza 1 mg Tablet 6's in the body.

How to manage the interaction:
Taking Telaprevir with Defza 1 mg Tablet 6's together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like high blood pressure, high blood glucose, muscle weakness, mood swings, acne, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and increased body fat, sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortCertolizumab
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Co-administration of Defza 1 mg Tablet 6's with Certolizumab may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Defza 1 mg Tablet 6's and Certolizumab, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DeflazacortAmprenavir
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Coadministration of Amprenavir with Defza 1 mg Tablet 6's can increase the levels of Defza 1 mg Tablet 6's in the body.

How to manage the interaction:
Taking Amprenavir with Defza 1 mg Tablet 6's together can result in an interaction. It can be taken if your doctor has advised it. However, if you experience symptoms like muscle weakness, excessive growth of facial or body hair, sudden dizziness, lightheadedness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortDarunavir
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Coadministration of Darunavir with Defza 1 mg Tablet 6's can increase the levels of Defza 1 mg Tablet 6's in the body. This increases the risk of side effects.

How to manage the interaction:
Taking Darunavir with Defza 1 mg Tablet 6's together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortPosaconazole
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Coadministration of Defza 1 mg Tablet 6's with posaconazole can increase the levels of Defza 1 mg Tablet 6's in your blood.

How to manage the interaction:
Although there is an interaction between posaconazole and Defza 1 mg Tablet 6's, it can be taken if your doctor has advised it. However, if you experience muscle weakness, mood swings, acne, stretch marks, easy bruising, menstrual irregularities, excessive growth of facial or body hair, or increased body fat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortDabrafenib
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Co- administration of Dabrafenib with Defza 1 mg Tablet 6's may significantly reduce the blood levels of Defza 1 mg Tablet 6's, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Dabrafenib and Defza 1 mg Tablet 6's together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
DeflazacortFluconazole
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Co-administration of Fluconazole with Defza 1 mg Tablet 6's can increase the levels of Defza 1 mg Tablet 6's in the body.

How to manage the interaction:
Taking Fluconazole with Defza 1 mg Tablet 6's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like muscle weakness, excessive growth of facial or body hair, or sudden dizziness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortLevofloxacin
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
coadministration of Levofloxacin and Defza 1 mg Tablet 6's can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone).

How to manage the interaction:
Although there is an interaction, Levofloxacin can be taken with Defza 1 mg Tablet 6's if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area. Do not stop using any medications without talking to a doctor.
DeflazacortDexamethasone
Severe
How does the drug interact with Defza 1 mg Tablet 6's:
Taking Dexamethasone with Defza 1 mg Tablet 6's may significantly reduce the blood levels of Defza 1 mg Tablet 6's, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Dexamethasone and Defza 1 mg Tablet 6's together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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DEFLAZACORT-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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DEFLAZACORT-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit juice while on Defza 1 mg Tablet 6's therapy may elevate Defza 1 mg Tablet 6's levels in the bloodstream. Avoid or limit the consumption of grapefruit and grapefruit juice.

Diet & Lifestyle Advise

A patient needs to take extra care of hygiene & stay away from places/people believed to be a cause of infection as this drug affects a patient's immune system & thus proper care is to be taken.

 

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Defza 1 mg Tablet Substitute

Substitutes safety advice
  • Defcort 1 Tablet 10's

    2.70per tablet
  • Defcort 1 Tablet 6's

    4.50per tablet
  • Dezacor 1 mg Tablet 10's

    2.75per tablet
  • Defnalone 1 mg Tablet 10's

    1.50per tablet
  • Deflaz 1 mg Tablet 6's

    9.67per tablet
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Alcohol

Caution

The effect of taking both alcohol and Defza 1 mg Tablet may lead to bleeding & ulcers in the stomach. Doctors' consultation is recommended.

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Pregnancy

Unsafe

Not recommended in pregnant females.Defza 1 mg Tablet crosses the placenta and doses equivalent to >40 mg prednisolone daily increase the risk of fetal and neonatal damage.

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Breast Feeding

Caution

No adverse effect is reported yet it is advised to have doctors' consultation by breastfeeding mothers.

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Driving

Unsafe

A patient may experience muscle weakness/feeling tired. Do not drive and do not use tools or machines while using this drug.

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Liver

Caution

If you've ever had hepatitis B or if you are a carrier of hepatitis B, using Defza 1 mg Tablet can cause this virus to become active or get worse. You may need frequent liver function tests. If you need surgery, tell the surgeon ahead of time that you are using Defza 1 mg Tablet.

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Kidney

Caution

Before using Defza 1 mg Tablet by a kidney patient it is recommended to have a doctors consultation. It may affect the kidney in a few cases.

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Children

Unsafe

Defza 1 mg Tablet is not recommended for children below 5 years of age. Children between 5-10 years of age should consult a doctor before using Defza 1 mg Tablet.

FAQs

Defza 1 mg Tablet is used to treat Duchene muscular dystrophy. It may also be used to treat allergic and inflammatory disorders.
Not recommended in mild allergies. Defza 1 mg Tablet is recommended only on consulting a doctor as Defza 1 mg Tablet is a strong medicine that produces considerable side effects & thus used only in moderate to severe cases.
It is not recommended to stop by a patient himself/herself, especially by a patient undergoing organ transplantation as it may worsen the situation.
It is not recommended to be taken Defza 1 mg Tablet with alcohol as it may cause stomach bleeding.
No its is not recommended to be used in seasonal allergy or mild cases. Only on doctors consultation, Defza 1 mg Tablet may be used in extreme cases of seasonal allergy.
You should not use Defza 1 mg Tablet if you have taken live vaccines of mumps, measles, rubella (MMR), polio, rotavirus, yellow fever, typhoid, nasal flu (influenza), varicella (chickenpox), and zoster (shingles). Do not take Defza 1 mg Tablet if you have a compromised immune system, eye problems or weak bones.
Yes, Defza 1 mg Tablet is a steroid medication. It's a corticosteroid, also known as a glucocorticoid.
Defza 1 mg Tablet is less potent than Prednisone and is usually administered proportionately in higher doses.
No, Defza 1 mg Tablet is not a painkiller. It is a steroid medication.
Yes, it can be used to treat kidney stones.
Swallow it whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the course. Do not chew or crush it. If you cannot swallow the tablet as a whole, you may break the pill into half and take both halves one at a time.
It may be unsafe for some to use. So please inform your doctor about your medical conditions and medications. Your doctor will decide whether it is suitable for you or not.
Yes, it is safe to use Defza 1 mg Tablet if prescribed by the doctor. Take it in the dose and duration prescribed by the doctor.
Inadequate data available on the use of this drug in pregnant women to inform a drug-related risk. So, it should be used during pregnancy only if the benefit outweighs the risk to the fetus.
Common side effects of Defza 1 mg Tablet may include nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhoea and fast heartbeats. Most of these side effects of Defza 1 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Store in a cool and dry place away from sunlight. Please keep it away from pets and children.

Country of origin

INDIA

Manufacturer/Marketer address

7-2-A2, Hetero Corporate, Industrial Estates, Sanath Nagar, Hyderabad – 500 018. Telangana, INDIA
Other Info - DEF0027

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