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compositionComposition:DEFERASIROX-250MG
prescription
Prescription Medicine
info
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Deferataj 250mg Tablet DT is used to treat iron overload due to transfusional hemosiderosis (the accumulation of iron in the body due to frequent blood transfusions) or non-transfusion-dependent thalassemia (patients who do not require lifelong regular transfusions for survival). It works by binding to the extra iron and facilitates its removal from the body through faeces. In some cases, this medicine may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, and skin rashes.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DEFERASIROX-250MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Deferataj 250mg Tablet DT

Deferataj 250mg Tablet DT is an oral prescription medicine used to treat chronic iron overload in the body. This condition often happens when you receive frequent blood transfusions or have certain blood disorders. By removing excess iron, this medicine helps prevent damage to your vital organs over time.

To get the best results, you must take Deferataj 250mg Tablet DT once daily at the same time every day, on an empty stomach or with a light meal. Staying consistent with this daily routine is key to keeping your iron levels in a safe range.

While taking this medicine, you might experience mild side effects like nausea, diarrhoea, or skin rashes. However, it is crucial to contact your doctor immediately if you experience severe abdominal pain, yellowing of your eyes or skin, or a sudden decrease in urination.

Do not take this if you have severe kidney disease, advanced liver disease, or high-risk myelodysplastic syndrome. Before starting Deferataj 250mg Tablet DT, tell your doctor if you have a history of ulcers, bleeding in your stomach, or blood disorders.

This medicine can interact with certain pain relievers, blood thinners, and antacids, which can increase your risk of stomach bleeding or lower the medicine's effectiveness. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist before starting this treatment.

Uses of Deferataj 250mg Tablet DT

Deferataj 250mg Tablet DT is used for treating chronic iron overload that occurs due to blood transfusions. The detailed uses of Deferataj 250mg Tablet DT are as follows:

  • Chronic iron overload from blood transfusions: When you receive multiple blood transfusions, your body accumulates excess iron that it cannot naturally remove. Deferataj 250mg Tablet DT binds to this extra iron so your body can pass it out through waste.
  • Chronic iron overload in non-transfusion-dependent thalassemia: Some blood disorders cause your body to absorb too much iron from food, even without blood transfusions. Deferataj 250mg Tablet DT helps lower these elevated iron levels to safe ranges.

Key Benefits

Deferataj 250mg Tablet DT helps protect your vital organs, such as your liver, heart, and pancreas, from the toxic effects of iron buildup.

Benefits may include:

  • By removing excess iron from your body, Deferataj 250mg Tablet DT helps protect important organs such as the liver, heart, and pancreas from iron-related damage, supporting long-term health.
  • Regular treatment helps keep iron levels under control, reducing the risk of complications associated with chronic iron overload.
  • Unlike older iron-removal therapies that required lengthy daily infusions under the skin, Deferataj 250mg Tablet DT is available as an oral tablet, making treatment more convenient and easier to fit into your daily routine.
  • Its easy-to-take oral formulation allows you to manage your condition at home with minimal disruption to your everyday activities.
Side effects of Deferataj 250mg Tablet DT
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Deferataj 250mg Tablet DT should be taken on an empty stomach, at least 30 minutes before a meal.
  • Follow your doctor's instructions on the dosage and timing of this medication. However, it is suggested to take Deferataj 250mg Tablet DT at the same time each day to maintain a consistent level of medicine in your body.
  • Swallow the whole Deferataj 250mg Tablet DT with a glass of water.
  • Do not break, chew, or crush it.

How Deferataj 250mg Tablet DT Works

Deferataj 250mg Tablet DT works as an iron chelator, which binds tightly to the free, excess iron molecules and forms a stable compound that your body can easily process. This bound iron is then naturally filtered out and excreted from your body, primarily through your bowel movements (faeces). This process gradually lowers your total body iron stores to a safer level.
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Alcohol

Caution

Consuming alcohol along with Deferataj 250mg Tablet DT is not advisable, as it may cause unpleasant side effects, or you also may become more sensitive to the effects of alcohol.

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Pregnancy

Consult your doctor

Deferataj 250mg Tablet DT is not usually recommended if you are pregnant. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks. Please consult the doctor.

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Breast Feeding

Consult your doctor

Deferataj 250mg Tablet DT is not usually recommended if you are a lactating woman. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.

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Driving

Caution

It is not known whether Deferataj 250mg Tablet DT alters the ability to drive, so do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.

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Liver

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Deferataj 250mg Tablet DT should be used under the supervision of healthcare provider

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Heart

Caution

Deferataj 250mg Tablet DT should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Deferataj 250mg Tablet DT.

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Geriatrics

Caution

Deferataj 250mg Tablet DT should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Deferataj 250mg Tablet DT

If you accidentally take too much Deferataj 250mg Tablet DT, seek emergency medical attention or contact a poison control centre immediately. Overdose can lead to severe stomach upset, liver or kidney issues, and other serious health complications.

Diet & Lifestyle Advise

  • Avoid vitamin C supplements: High doses of vitamin C can increase how much iron your body absorbs and may interact with how this medicine works. Only take vitamin C if specifically directed by your doctor.
  • Stay well hydrated: Drink plenty of water throughout the day. This helps your kidneys flush out waste and reduces the strain on your kidneys while taking this medicine.
  • Avoid iron-fortified foods: Limit your intake of foods that are heavily fortified with iron, and avoid using cast-iron cookware, as this can add extra iron to your food.
  • Limit alcohol consumption: Alcohol can put extra stress on your liver. Since both iron overload and this medicine can affect your liver, it is best to limit or avoid alcohol.
health query

Have a query?

How Soon It Starts Working

  • The time required for Deferataj 250mg Tablet DT to start to work: The exact onset time of Deferataj 250mg Tablet DT has not been clinically established.
  • The time for which the effects of Deferataj 250mg Tablet DT last: The duration of Deferataj 250mg Tablet DT’s effect is clinically not established.

What if you forget to take Deferataj 250mg Tablet DT

If you miss a dose, take it as soon as you remember on that day. However, if it is almost time for your next dose, skip the missed one and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Deferataj 250mg Tablet DT at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Get regular blood tests: You will need frequent blood and urine tests to monitor your kidney and liver function, as well as your iron levels. Do not skip these appointments.
  • Schedule eye and ear exams: This medicine can occasionally affect your vision and hearing. Your doctor may recommend regular checkups to monitor for any changes.
  • Do not take with aluminium-containing antacids: These products can bind to the medicine in your stomach and stop it from working correctly.
  • Watch for skin changes: If you develop any skin rash that spreads, blisters, or peels, stop taking the medicine and contact your doctor immediately.
  • Report unusual bruising or bleeding: If you notice unusual bruising, nosebleeds, or blood in your urine, notify your healthcare provider right away.

Drug-Drug Interactions

verifiedApollotooltip
  • Aluminium-containing antacids: May bind to Deferataj 250mg Tablet DT in your digestive tract, reducing its absorption and making it less effective.
  • Blood thinners (e.g., warfarin): Taking these medicines with Deferataj 250mg Tablet DT can increase your risk of stomach ulcers and internal bleeding.
  • NSAID pain relievers (e.g., ibuprofen): May increase the risk of stomach irritation, ulcers, and internal bleeding.
  • Certain cholesterol-lowering drugs (e.g., cholestyramine): May lower the levels of Deferataj 250mg Tablet DT in your body, reducing its effectiveness.
  • Antihyperglycemic agents (e.g., repaglinide): Deferataj 250mg Tablet DT can increase the levels of repaglinide in your body, raising the risk of low blood sugar (hypoglycaemia).
DeferasiroxRisedronic acid
Severe
DeferasiroxRuxolitinib
Severe

Drug-Drug Interactions

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DeferasiroxRisedronic acid
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Taking Risedronic acid (oral form) with Deferataj 250mg Tablet DT can increase the risk of bleeding and ulcers in the stomach.

How to manage the interaction:
Taking Risedronic acid with Deferataj 250mg Tablet DT together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools. Do not discontinue any medications without consulting a doctor.
DeferasiroxRuxolitinib
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Using Deferataj 250mg Tablet DT together with Ruxolitinib may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking Deferataj 250mg Tablet DT and Ruxolitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience abdominal pain, bloating, dizziness, lightheadedness, loss of hunger, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools call a doctor. Do not discontinue any medications without consulting a doctor.
DeferasiroxDexamethasone
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Taking Dexamethasone with Deferataj 250mg Tablet DT may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Deferataj 250mg Tablet DT if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of gastrointestinal injury such as abdominal pain, bloating, dizziness, lightheadedness, loss of appetite, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools. Do not discontinue the medication without consulting a doctor.
DeferasiroxLeflunomide
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Leflunomide may cause liver problems and using it with Deferataj 250mg Tablet DT may increase that risk.

How to manage the interaction:
Taking Leflunomide with Deferataj 250mg Tablet DT together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or any other unusual signs, make sure to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
DeferasiroxTheophylline
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Taking Deferataj 250mg Tablet DT with theophylline may significantly increase the blood levels of theophylline.

How to manage the interaction:
Although taking Deferataj 250mg Tablet DT and theophylline together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, diarrhea, loss of hunger, headache, shaking, confusion, restlessness, sleeplesness, fits, heart palpitations, and/or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
DeferasiroxBacitracin
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Deferataj 250mg Tablet DT may cause kidney problems and combining it with bacitracin may increase that risk.

How to manage the interaction:
Although taking Bacitracin and Deferataj 250mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxStreptomycin
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Coadministration of Deferataj 250mg Tablet DT and Streptomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Deferataj 250mg Tablet DT and Streptomycin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience a fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash consult a doctor. Do not discontinue any medications without consulting a doctor.
DeferasiroxStreptokinase
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Combining Streptokinase with Deferataj 250mg Tablet DT can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Co-administration of Streptokinase with Deferataj 250mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxNabumetone
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Taking Nabumetone and Deferataj 250mg Tablet DT together can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Nabumetone with Deferataj 250mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxKetoconazole
Severe
How does the drug interact with Deferataj 250mg Tablet DT:
Coadministration of Ketoconazole and Deferataj 250mg Tablet DT may increase the risk of liver injury.

How to manage the interaction:
Although taking Ketoconazole and Deferataj 250mg Tablet DT together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Deferataj 250mg Tablet DT when used as directed.

DEFERASIROX-250MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-250MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Deferataj 250mg Tablet DT. Avoid consumption of caffeinated drinks during the treatment with Deferataj 250mg Tablet DT. If you experience any unusual symptoms call a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHELATING AGENTS]

FAQs

Deferataj 250mg Tablet DT is used to treat chronic iron overload due to blood transfusions (transfusional hemosiderosis).
Deferasirox is the active component in Deferataj 250mg Tablet DT. It is a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.
No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.
Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.
Deferataj 250mg Tablet DT is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.
The extra iron due to iron overload is stored in pancreas. This damages the pancreas and it does not produce insulin properly. Insulin is required by the body to utilise sugar/glucose efficiently. As insulin is not produced properly, it affects blood sugar levels.
Yes, iron overload is the same as haemochromatosis. Hemochromatosis, or iron overload, is a condition in which your body stores too much iron.
Yes, Deferataj 250mg Tablet DT can be used in children above 2 years if prescribed by the doctor. Talk to the doctor if you have any concerns regarding this.
Deferataj 250mg Tablet DT may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
It depends on the specific tablet type your doctor prescribes. Some formulations of Deferataj 250mg Tablet DT must be taken on an empty stomach, while others can be taken with a light meal. Check your prescription label or talk to your doctor or pharmacist for specific instructions.
Deferataj 250mg Tablet DT works gradually over several weeks and months. Your doctor will monitor your blood iron levels regularly to track your progress and see how well the medicine is working. Talk to your doctor or pharmacist to understand your specific treatment timeline.
Avoid taking aluminum-containing antacids, high-dose vitamin C supplements, and drinking excessive alcohol. You should also consult your doctor before taking any new over-the-counter pain relievers or herbal supplements.
Yes, Deferataj 250mg Tablet DT can affect kidney function in some patients. Your doctor will perform regular blood and urine tests to monitor your kidney health while you are taking this medication. Talk to your doctor or pharmacist if you notice a decrease in urination or swelling in your feet.
It is best to take Deferataj 250mg Tablet DT at the same time every day to maintain a consistent level of the medication in your body. Choose a time that is easy for you to remember and fits your daily routine.
It is highly recommended to limit or avoid alcohol while taking Deferataj 250mg Tablet DT. Both alcohol and this medicine can place extra stress on your liver, increasing the risk of liver damage. Talk to your doctor or pharmacist for personalised advice.
The safety of Deferataj 250mg Tablet DT during pregnancy has not been fully established. If you are pregnant, planning to become pregnant, or breastfeeding, do not start this medication without discussing the risks and benefits with your doctor.
A mild skin rash can sometimes occur. However, because some rashes can become severe, you should contact your doctor immediately if you notice a rash, itching, or skin peeling. Talk to your doctor or pharmacist for advice on managing skin reactions.

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Country of origin

India
Other Info - DE60558
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