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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Defcort 24 Tablet is used to treat Duchenne muscular dystrophy in children above 2 years of age. It contains deflazacort, which binds to immune cells, resulting in the inhibition of inflammation and autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. It makes organ transplantation possible and treats muscle disorders like Duchenne muscular dystrophy. Some children may experience side effects such as nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhea, and fast heartbeats. Before giving this medicine, tell your doctor if your child is allergic to any of its components. Let the doctor know if your child is taking any other medication or has pre-existing medical conditions.

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Synonym :

CALCORT

Composition :

DEFLAZACORT-24MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Defcort 24 Tablet

Defcort 24 Tablet is used to treat Duchenne muscular dystrophy (DMD is a genetic disorder that causes muscles to weaken and waste away) in children over two years of age. DMD is a hereditary condition that causes gradual muscle weakness, usually in boys.

Defcort 24 Tablet contains Deflazacort, an immunosuppressive drug that works by reducing inflammation (swelling) and altering the immune system's function. As a result, Defcort 24 Tablet helps with autoimmune disorders and inflammation that damages different organs, particularly the joints in psoriasis and arthritis.

Defcort 24 Tablet should be administered as prescribed. Your doctor will recommend how often you give Defcort 24 Tablet to your child based on their medical condition. Some children may experience nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhea, and fast heartbeats. Most of these side effects do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your child's doctor. Do not quit giving deflazacort without consulting your doctor. Symptoms such as loss of appetite, a disturbed stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss may be caused by stopping the medication suddenly.

Before you start giving Defcort 24 Tablet, please inform your doctor if your child is allergic (hypersensitive) to Defcort 24 Tablet. Extra care is to be taken when a child has an already existing infection being treated (systemic infection) or has recently had some live virus vaccines.

Uses of Defcort 24 Tablet

Defcort 24 Tablet is used to treat Duchenne muscular dystrophy (DMD).

Directions for Use

Use the measuring cup or dropper in the pack to give your child the recommended dose. Shake the bottle well before each use.

Medicinal Benefits

Defcort 24 Tablet is used to treat Duchenne muscular dystrophy (DMD), a rare hereditary muscular disease that primarily affects children and young adults. DMD is characterized by the absence of dystrophin, a protein that aids in maintaining the integrity of muscle cells. Deflazacort is a corticosteroid, or steroid that mimics cortisone. It treats autoimmune diseases such as atopic dermatitis, psoriasis, rheumatoid arthritis, and eczema. It reduces the immune system's reactivity to these ailments, lessening symptoms, including pain, swelling, itching, and other allergic reactions.

How Defcort 24 Tablet Works

Defcort 24 Tablet contains Deflazacort, an immunosuppressive drug that works by reducing inflammation (swelling) and altering the immune system's function. As a result, Defcort 24 Tablet helps with autoimmune disorders and inflammation that damages different organs, particularly the joints in psoriasis and arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Defcort 24 Tablet

  • Runny or stuffy nose
  • Skin redness
  • Irritability
  • Abdominal discomfort or pain
  • Irregular behaviour
  • Fever
  • Back pain
  • Acne
  • Nausea
  • Restlessness
  • Nosebleeds
  • Stretch marks

What if I have taken an overdose of Defcort 24 Tablet

Do not give more than the recommended dose to your child, as it might cause an overdose. Seek immediate medical attention if your child experiences any unusual symptoms.

Drug Warnings

If your child with a history of tuberculosis (TB), heart disease or heart failure, stomach disorders (gastritis, peptic ulcer), diabetes (including family history), osteoporosis (bone disease), myasthenia gravis (muscle weakness), depression, mental distress, history of muscular problems caused by corticosteroids, kidney and liver dysfunction (including hepatic insufficiency and cirrhosis), you should consult a doctor before giving Defcort 24 Tablet to them. This medicine is not recommended for children less than 5 years of age unless advised by your doctor. Keep the children away from people who are sick. Avoid giving them live vaccines 4-6 weeks before starting Defcort 24 Tablet to prevent harmful reactions.

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
DeflazacortMifepristone
Severe

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
How does the drug interact with Defcort 24 Tablet:
Co-administration of Defcort 24 Tablet and Desmopressin may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DeflazacortMifepristone
Severe
How does the drug interact with Defcort 24 Tablet:
Taking Mifepristone with Defcort 24 Tablet may significantly reduce the blood levels of Defcort 24 Tablet, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Mifepristone and Defcort 24 Tablet together can possibly result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
DeflazacortFosaprepitant
Severe
How does the drug interact with Defcort 24 Tablet:
Coadministration of Fosaprepitant with Defcort 24 Tablet can increase the levels of Defcort 24 Tablet in the body.

How to manage the interaction:
Taking Fosaprepitant with Defcort 24 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like high blood pressure, high blood glucose, muscle weakness, mood swings, acne, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortAmprenavir
Severe
How does the drug interact with Defcort 24 Tablet:
Coadministration of Amprenavir with Defcort 24 Tablet can increase the levels of Defcort 24 Tablet in the body.

How to manage the interaction:
Taking Amprenavir with Defcort 24 Tablet together can result in an interaction. It can be taken if your doctor has advised it. However, if you experience symptoms like muscle weakness, excessive growth of facial or body hair, sudden dizziness, lightheadedness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortNelfinavir
Severe
How does the drug interact with Defcort 24 Tablet:
Coadministration of Nelfinavir with Defcort 24 Tablet can increase the levels of Defcort 24 Tablet in the body.

How to manage the interaction:
Taking Nelfinavir with Defcort 24 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like high blood pressure, high blood glucose, muscle weakness, mood swings, acne, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and increased body fat, sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortAtazanavir
Severe
How does the drug interact with Defcort 24 Tablet:
Coadministration of Atazanavir with Defcort 24 Tablet can increase the levels of Defcort 24 Tablet in the body. This increases the risk of side effects.

How to manage the interaction:
Taking Atazanavir with Defcort 24 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortThalidomide
Severe
How does the drug interact with Defcort 24 Tablet:
Taking thalidomide together with Defcort 24 Tablet may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Defcort 24 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DeflazacortRifampicin
Severe
How does the drug interact with Defcort 24 Tablet:
Taking Rifampicin with Defcort 24 Tablet may reduce the blood levels of Defcort 24 Tablet, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between Defcort 24 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
DeflazacortSparfloxacin
Severe
How does the drug interact with Defcort 24 Tablet:
Sparfloxacin can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone), and the risk may be increased when combined with other drugs such as Defcort 24 Tablet.

How to manage the interaction:
Although there is an interaction, Sparfloxacin can be taken with Defcort 24 Tablet if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from your doctor. Do not stop using any medications without first talking to your doctor.
DeflazacortCladribine
Severe
How does the drug interact with Defcort 24 Tablet:
Co-administration of Defcort 24 Tablet with Cladribine may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Defcort 24 Tablet and Cladribine, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DEFLAZACORT-24MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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DEFLAZACORT-24MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit juice while on Defcort 24 Tablet therapy may elevate Defcort 24 Tablet levels in the bloodstream. Avoid or limit the consumption of grapefruit and grapefruit juice.

Diet & Lifestyle Advise

  • Your child needs to practice good hygiene and avoid places and people believed to be a cause of infection. This drug affects a child's immune system, so proper care must be taken.
  • Avoid eating grapefruit or drinking grapefruit juice while taking Defcort 24 Tablet, as it may interact with the medication.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Defcort 24 Tablet Substitute

Substitutes safety advice
  • Cortimax 24 mg Tablet 6's

    by Others

    46.20per tablet
  • Defza 24 Tablet 6's

    by Others

    48.50per tablet
  • Delacort 24 mg Tablet 10's

    by Others

    41.40per tablet
  • Orthocort 24 mg Tablet 6's

    by AYUR

    43.20per tablet
  • Kivicort-24 mg Tablet 6's

    by Others

    27.30per tablet
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Caution

Blood levels of Defcort 24 Tablet may rise in children with hepatic impairment. Consequently, it is essential to closely monitor and modify the deflazacort dosage to the lowest adequate level.

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Kidney

Caution

Limited information is available. If your child has kidney problems, inform the doctor beforehand.

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Children

Safe if prescribed

Defcort 24 Tablet is safe if prescribed by your doctor. However, please consult your doctor before giving Defcort 24 Tablet to your child. Defcort 24 Tablet is not recommended for children below 2 years of age.

FAQs

Defcort 24 Tablet is used to treat Duchene muscular dystrophy. It may also be used to treat allergic and inflammatory disorders.

You should not give Defcort 24 Tablet if your child has taken live vaccines of mumps, measles, rubella (MMR), polio, rotavirus, yellow fever, typhoid, nasal flu (influenza), varicella (chickenpox), and zoster (shingles). Do not give Defcort 24 Tablet if your child has a compromised immune system, eye problems, or weak bones.

Yes, Defcort 24 Tablet is a steroid medication. It's a corticosteroid, also known as a glucocorticoid.

No, Defcort 24 Tablet is not a painkiller. It is a steroid medication.

Yes, it is safe to use Defcort 24 Tablet if prescribed by the doctor. Give it in the dose and duration prescribed by the doctor.

Common side effects of Defcort 24 Tablet may include nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhea, and fast heartbeats. Most of these side effects of Defcort 24 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Store in a cool and dry place away from sunlight. Please keep it away from pets and children.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - DEF0013

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