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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Debrilyse Plus Tablet is used to treat pain and inflammation associated with conditions like osteoarthritis and rheumatoid arthritis. Additionally, it may also provide relief from toothache, ear pain, throat pain, muscle ache, and backache. This medicine reduces pain and inflammation by blocking the action of chemical messengers. It also increases the blood supply to the affected area and promotes healing.
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Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Debrilyse Plus Tablet

Debrilyse Plus Tablet is used to treat pain and inflammation associated with osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back) and rheumatoid arthritis (joint pain, especially in the hands and feet). It may also provide relief from toothache, ear pain, throat pain, muscle ache, and backache.

Debrilyse Plus Tablet contains Trypsin, Bromelain, Rutoside, and Diclofenac. Trypsin and Bromelain reduce pain and inflammation by increasing the blood supply to the affected area and promoting healing. Rutoside prevents swelling and inflammation by neutralizing the chemicals that cause cell damage. Diclofenac blocks the release of chemical substances that cause pain and inflammation.

Take Debrilyse Plus Tablet exactly as prescribed by your doctor. Debrilyse Plus Tablet may cause side effects such as nausea, vomiting, stomach pain, indigestion, heartburn, stomach upset, diarrhoea, and headache. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.

Consult your doctor if you are pregnant or breastfeeding. Debrilyse Plus Tablet is not recommended for children below 12 years of age. Debrilyse Plus Tablet may cause dizziness, so do not drive or operate heavy machinery unless you are alert. Keep your doctor informed about your health conditions and medications to rule out any interactions/side effects.

Uses of Debrilyse Plus Tablet

Treatment of Pain relief

Directions for Use

Take Debrilyse Plus Tablet with food to avoid stomach upset. Swallow the medicine as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Debrilyse Plus Tablet is a combination of four medicines: Trypsin, Bromelain, Rutoside, and Diclofenac. Trypsin and Bromelain are enzymes with antiseptic and anti-inflammatory properties. They reduce pain and inflammation by increasing the blood supply to the affected area and promoting healing. Rutoside is an antioxidant and anti-inflammatory agent. It prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) that prevents the production of chemical substances (prostaglandins) that cause pain and inflammation.

How Debrilyse Plus Tablet Works

Debrilyse Plus Tablet contains Trypsin, Bromelain, Rutoside, and Diclofenac. Trypsin and Bromelain reduce pain and inflammation by increasing the blood supply to the affected area and promoting healing. Rutoside prevents swelling and inflammation by neutralizing the chemicals that cause cell damage. Diclofenac blocks the release of chemical substances that cause pain and inflammation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Debrilyse Plus Tablet

  • Nausea
  • Vomiting
  • Stomach pain
  • Indigestion
  • Heartburn
  • Stomach upset
  • Diarrhoea
  • Headache

What if I have taken an overdose of Debrilyse Plus Tablet

Take Debrilyse Plus Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Debrilyse Plus Tablet if you are allergic to any of its contents. Inform your doctor if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, angina, bowel problems, blood clotting disorder, a habit of smoking, or liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Stop taking Debrilyse Plus Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
DiclofenacSulindac
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Debrilyse Plus Tablet:
Co-administration of Debrilyse Plus Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Debrilyse Plus Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacSulindac
Severe
How does the drug interact with Debrilyse Plus Tablet:
Co-administration of Debrilyse Plus Tablet and sulindac can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Debrilyse Plus Tablet and sulindac, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacDabigatran etexilate
Severe
How does the drug interact with Debrilyse Plus Tablet:
Concomitant use of Debrilyse Plus Tablet with dabigatran may increase the risk of stomach bleeding.

How to manage the interaction:
Taking Debrilyse Plus Tablet with dabigatran together possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, light headedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
DiclofenacDeferasirox
Severe
How does the drug interact with Debrilyse Plus Tablet:
Co-administration of Debrilyse Plus Tablet and deferasirox may increase your risk of developing stomach bleeding.

How to manage the interaction:
There may be a possible interaction between Debrilyse Plus Tablet and deferasirox but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, weakness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
DiclofenacKetorolac
Severe
How does the drug interact with Debrilyse Plus Tablet:
Co-administration of Debrilyse Plus Tablet and Ketorolac can increase the risk of side effects.

How to manage the interaction:
Co-administration of Debrilyse Plus Tablet and Ketorolac can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacOmacetaxine mepesuccinate
Severe
How does the drug interact with Debrilyse Plus Tablet:
Taking Debrilyse Plus Tablet with Omacetaxine mepesuccinate can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Debrilyse Plus Tablet and Omacetaxine mepesuccinate but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacSirolimus
Severe
How does the drug interact with Debrilyse Plus Tablet:
Co-administration of Debrilyse Plus Tablet with Sirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Debrilyse Plus Tablet and Sirolimus can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
DiclofenacAcalabrutinib
Severe
How does the drug interact with Debrilyse Plus Tablet:
Taking acalabrutinib together with Debrilyse Plus Tablet may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Debrilyse Plus Tablet and Acalabrutinib can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacTolmetin
Severe
How does the drug interact with Debrilyse Plus Tablet:
Taking Debrilyse Plus Tablet with Tolmetin may increase the risk of side effects.

How to manage the interaction:
There may be a possible interaction between Debrilyse Plus Tablet and Tolmetin but can be taken if prescribed by doctor. However, consult your doctor immediately if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medications without consulting a doctor.
DiclofenacFurosemide
Severe
How does the drug interact with Debrilyse Plus Tablet:
Concomitant administration of Debrilyse Plus Tablet and furosemide may decrease the therapeutic efficacy of furosemide and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between Debrilyse Plus Tablet and furosemide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on the treadmill, bike riding, and swimming. You can also strengthen your muscles by lifting light weights.

  • Try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize levels of chemicals called cytokines, which ramp up inflammation.

  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

Debrilyse Plus Tablet Substitute

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Alcohol

Caution

It is not known if alcohol interacts with Debrilyse Plus Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

If you are pregnant, please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding. Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

Debrilyse Plus Tablet may cause blurred vision and dizziness. So, do not drive or operate heavy machinery unless you are alert.

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Liver

Caution

Debrilyse Plus Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Debrilyse Plus Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Debrilyse Plus Tablet is not recommended for children below 12 years of age.

FAQs

Debrilyse Plus Tablet is used to relieve pain and inflammation associated with osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back) and rheumatoid arthritis (joint pain, especially in the hands and feet). It may also provide relief from toothache, ear pain, throat pain, muscle ache, and backache.
Debrilyse Plus Tablet contains Trypsin, Bromelain, Rutoside, and Diclofenac. Trypsin and Bromelain reduce pain and inflammation by increasing the blood supply to the affected area and promoting healing. Rutoside prevents swelling and inflammation by neutralizing the chemicals that cause cell damage. Diclofenac blocks the release of chemical substances that cause pain and inflammation.
Debrilyse Plus Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is tenderness and swelling in the joints.
Avoid exceeding the dose and duration advised by the doctor. Debrilyse Plus Tablet should not be taken for longer durations unless prescribed by your doctor.
If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the scheduled dose. Avoid taking a double dose.
Debrilyse Plus Tablet may cause dizziness as it is one of its common side effects. However, please consult a doctor if this side effect persists for longer durations.
Debrilyse Plus Tablet is contraindicated in individuals with known allergies to its ingredients, and those with high blood pressure, heart issues, diabetes, asthma, bowel problems, liver/kidney issues, or a smoking habit. Consult a doctor if pregnant or breastfeeding. Discontinue and seek medical advice if stomach pain or signs of bleeding occur.
Do not take higher than the recommended dose of Debrilyse Plus Tablet as it can lead to increased side effects. Therefore, do not exceed the recommended dose. If your symptoms worsen, please consult your doctor.
Store Debrilyse Plus Tablet at room temperature in a dry place as advised on the label. Protect from light. Keep it out of reach of children.
Debrilyse Plus Tablet is typically for short-term use and can be stopped when pain and swelling subside. However, if your doctor has advised you, continue taking Debrilyse Plus Tablet .
Yes, the use of Debrilyse Plus Tablet can cause nausea and vomiting. Take it with food, milk or antacids to prevent nausea. If vomiting occurs, drink plenty of water or other fluids by taking small frequent sips. However, if these side effects persist, consult your doctor.
You are recommended to contact a doctor before taking Debrilyse Plus Tablet for dental pain or menstrual cramps, as it may not be suitable for all types of pain.
Debrilyse Plus Tablet causes side effects such as nausea, dizziness, vomiting, stomach pain, indigestion, heartburn, headache, and diarrhoea. These do not require any medical treatment as they will gradually reduce over time. Consult a doctor if these side effects persist for longer durations.
Debrilyse Plus Tablet is contraindicated if you are allergic to any of its contents. Inform your doctor if you have a history of stomach ulcers or perforations, bleeding disorders, heart attack, bypass surgery, blood circulation problems, intestinal inflammation, anemia, or kidney and liver issues.
Debrilyse Plus Tablet is prescribed during pregnancy and breastfeeding only if your doctor thinks that the benefits are greater than the potential risks. The safety of Debrilyse Plus Tablet during pregnancy or nursing has not been fully established. Therefore, consult your doctor before taking Debrilyse Plus Tablet if you are pregnant or nursing. Do not self-medicate.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - DEB0030

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