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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dasafav 20 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Composition :

DASATINIB-20MG

Manufacturer/Marketer :

Aureate Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

About Dasafav 20 Tablet

Dasafav 20 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. Dasafav 20 Tablet is used in the treatment of chronic myelogenous leukemia (CML) in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) who are resistant or intolerant to prior therapy, in patients with newly diagnosed chronic Ph+ chronic myelogenous leukemia (CML). This medicine is also used in the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

Dasafav 20 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Dasafav 20 Tablet may cause certain side effects, such as skin rash, fatigue, headache, musculoskeletal pain, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, GI bleeding, muscle inflammation, myalgia, and difficulty breathing. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Dasafav 20 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Dasafav 20 Tablet based on the severity of your condition.

Dasafav 20 Tablet should be avoided if you are allergic to it or any other components present in it. Before taking Dasafav 20 Tablet, caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, cardiac problems, and myelosuppression as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Dasafav 20 Tablet. Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Dasafav 20 Tablet

Treatment of Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia

Directions for Use

Take Dasafav 20 Tablet as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Dasafav 20 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins (BCR-ABL tyrosine kinase) that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. Dasafav 20 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.

How Dasafav 20 Tablet Works

Dasafav 20 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dasafav 20 Tablet

  • Nausea
  • Diarrhoea
  • Decreased platelet count
  • Fatigue
  • Edema
  • Vomiting
  • Diarrhea
  • Headache
  • Back pain
  • Dizziness
  • Skin rash
  • Difficulty breathing
  • GI bleeding
  • Myalgia

What if I have taken an overdose of Dasafav 20 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Dasafav 20 Tablet are unusual bruising or bleeding, fever, sore throat, chills, and/or other signs of infection, shortness of breath, fast heartbeat, headache, pale skin, confusion and tiredness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Dasafav 20 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, or gastrointestinal disorders, as the use of Dasafav 20 Tablet in these patients may cause serious side effects. Dasafav 20 Tablet may cause myelosuppression, fluid retention, gastrointestinal haemorrhage, QT prolongation, congestive heart failure, Left ventricular dysfunction and Myocardial infarction. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Dasafav 20 Tablet is given in children above one year of age only if prescribed by the doctor. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DasatinibHalofantrine
Critical
DasatinibDronedarone
Critical

Drug-Drug Interactions

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DasatinibHalofantrine
Critical
How does the drug interact with Dasafav 20 Tablet:
Using Halofantrine together with Dasafav 20 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dasafav 20 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
DasatinibDronedarone
Critical
How does the drug interact with Dasafav 20 Tablet:
Using dronedarone together with Dasafav 20 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dasafav 20 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibMesoridazine
Critical
How does the drug interact with Dasafav 20 Tablet:
Using Mesoridazine together with Dasafav 20 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Dasafav 20 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibPimozide
Critical
How does the drug interact with Dasafav 20 Tablet:
Using Pimozide together with Dasafav 20 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dasafav 20 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibAnagrelide
Severe
How does the drug interact with Dasafav 20 Tablet:
Using Anagrelide together with Dasafav 20 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Dasafav 20 Tablet and Anagrelide, but it can be taken if prescribed by a doctor. If you have symptoms like fainting, dizziness, breathlessness, or heart palpitations, consult a doctor. Do not stop using any medications without a doctor's advice.
DasatinibMefenamic acid
Severe
How does the drug interact with Dasafav 20 Tablet:
Co-administration of Mefenamic acid with Dasafav 20 Tablet can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefenamic acid with Dasafav 20 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
DasatinibAmiodarone
Severe
How does the drug interact with Dasafav 20 Tablet:
Co-administration of Dasafav 20 Tablet with Amiodarone may increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although taking Dasafav 20 Tablet with Amiodarone may cause an interaction, it is safe if a doctor has prescribed it. If you develop dizziness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor. Do not stop taking any medications without visiting a doctor.
DasatinibEtanercept
Severe
How does the drug interact with Dasafav 20 Tablet:
Using Etanercept together with Dasafav 20 Tablet may increase the risk of infections.

How to manage the interaction:
Although taking Etanercept and Dasafav 20 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, muscle pains, breathing difficulty, and discomfort or burning when you urinate, consult a doctor. Do not stop taking any medications without consulting a doctor.
DasatinibIvabradine
Severe
How does the drug interact with Dasafav 20 Tablet:
Coadministration of Ivabradine with Dasafav 20 Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Ivabradine with Dasafav 20 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience dizziness, shortness of breath, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
DasatinibBaricitinib
Severe
How does the drug interact with Dasafav 20 Tablet:
Using baricitinib together with Dasafav 20 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Dasafav 20 Tablet, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DASATINIB-20MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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DASATINIB-20MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice can significantly increase the blood levels and effects of Dasafav 20 Tablet. Avoid consumption of Grapefruit juice with Dasafav 20 Tablet. However, contact a doctor if you experience dizziness, shortness of breath, heart palpitations, pain, or burning during urination.

Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Dasafav 20 Tablet Substitute

Substitutes safety advice
  • Dasanat 20 Tablet 60's

    41.00per tablet
  • Spnib 20 Tablet 60's

    16.43per tablet
  • Sprycel 20mg Tablet

    1131.87per tablet
  • Beedan 20 mg Tablets 60's

    85.33per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Dasafav 20 Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Dasafav 20 Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Dasafav 20 Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Dasafav 20 Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Dasafav 20 Tablet. Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Dasafav 20 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Dasafav 20 Tablet or until you become alert.

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Liver

Caution

Use Dasafav 20 Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Dasafav 20 Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Dasafav 20 Tablet is safe for use in children above one year of age if prescribed by the doctor.

FAQs

Dasafav 20 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Dasafav 20 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Dasafav 20 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Dasafav 20 Tablet as antacids may alter the absorption of this medicine.

Country of origin

India

Manufacturer/Marketer address

2nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - DA48291

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