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Darbecure-40 Injection

Darbecure-40 Injection

Prescription drug
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Consult Doctor

Manufacturer/Marketer

Emcure Pharmaceuticals Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

for this medicine

About Darbecure-40 Injection

Darbecure-40 Injection belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darbecure-40 Injection helps to reverse anaemia and reduce the need for blood transfusion. Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

Darbecure-40 Injection contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darbecure-40 Injection is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darbecure-40 Injection stimulates the production of this protein in the bone marrow. 

Darbecure-40 Injection will be injected by the healthcare provider. Do not self-administer. The most common side effects of Darbecure-40 Injection are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these sides effects of Darbecure-40 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to darbepoetin alfa or epoetin alfa, please inform your doctor before taking Darbecure-40 Injection to avoid any complications. Also, mention all the other medications you are taking to affect the way Darbecure-40 Injection works. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be signs that the body has stopped responding to Darbecure-40 Injection. 

Uses of Darbecure-40 Injection

Treatment of Anaemia (in cancer and chronic kidney disease)

Medicinal Benefits

Darbecure-40 Injection is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn cause low red blood cells count causing anaemia.  This medicine is primarily indicated for treating anaemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells' cancer. Darbecure-40 Injection contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

Directions for Use

Darbecure-40 Injection will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Darbecure-40 Injection

  • Shortness of breath
  • Cough
  • Hypotension (low blood pressure)
  • Headache
  • Body aches
  • Diarrhoea
  • Injection site pain 
  • Abdominal pain (stomach pain) 

 

Drug Warnings

Darbecure-40 Injection can enhance the risk of serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may also shorten survival time in some people with certain types of cancer. Inform your doctor before taking Darbecure-40 Injection if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Darbecure-40 Injection if you are pregnant or breastfeeding unless prescribed by the doctor. Darbecure-40 Injection may affect a person's ability to drive as it may cause convulsion during initial days of treatment, so a person taking Darbecure-40 Injection should avoid driving or operating any machine. Darbecure-40 Injection should not be given to children below 12 years of age, as safety and effectiveness have not been established. Avoid consuming alcohol along with Darbecure-40 Injection as it could lead to increased dizziness and sleepiness. 

Drug Interactions

Drug-Drug Interactions: Darbecure-40 Injection may have interaction with other chemotherapy drugs (thalidomide),  immunosuppressant medication (cyclosporine),  antihypertensive medicines (captopril). 

Drug-Food Interactions: Avoid alcohol consumption while taking Darbecure-40 Injection as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Darbecure-40 Injection may have interactions with disease conditions such as seizures, hemodialysis, hypertension, and thrombotic events
 

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • CYCLOSPORINE
  • CAPTOPRIL

Habit Forming

No

Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfil the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that give you enough energy to be active during the day; however, try to limit fats that make you fatty. Try to include olive oil, peanut oil, and corn oil into your diet.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Special Advise

  • Certain diagnostic tests like Complete blood count (CBC) can help check the count of red blood cells.
  • Have regular haemoglobin tests to check whether there is an improvement in the level of red blood cells after taking Darbecure-40 Injection or not.

Disease/Condition Glossary

Anaemia: It occurs when the body has a lower amount of red blood cells or haemoglobin than normal haemoglobin (iron-rich the protein responsible for allowing red blood cells to carry more oxygen from the lungs to the rest of the body).  In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia. Symptoms of anaemia in chronic kidney disease include fatigue or tiredness, shortness of breath, ashen skin, weakness, body aches, chest pain, dizziness, fainting, fast or irregular heartbeat, headache, sleep problems, and trouble in concentrating. 

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Darbecure-40 Injection as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Darbecure-40 Injection if you are pregnant unless prescribed by a doctor as Darbecure-40 Injection is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Darbecure-40 Injection; your doctor will decide whether Darbecure-40 Injection can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Darbecure-40 Injection causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Darbecure-40 Injection should not be given to children as the safety and efficacy have not been established.

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - DAR0064

Author Details

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FAQs

Darbecure-40 Injection is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darbecure-40 Injection helps to reverse anaemia and reduce the need for blood transfusion.
It is suggested to store the Darbecure-40 Injection in the refrigerator and protect it from light. However, a person should not freeze it.
It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.
A person who is allergic to any chemical compound present in Darbecure-40 Injection or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
Consult your doctor before taking Darbecure-40 Injection if you are pregnant or planning for pregnancy. Your doctor will prescribe Darbecure-40 Injection only if the benefits outweigh the risks.
Darbecure-40 Injection contains a protein "Darbepoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.

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Keep Refrigerated. Do not freeze.Prepaid payment required.

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