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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Darbecon 25Mcg/0.42Ml Inj is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). It helps to reverse anaemia and reduce the need for blood transfusion. It contains Darbepoetin alfa, which works by providing signals to the bone marrow to make more red blood cells. In chronic kidney disease, when the kidney fails to produce sufficient erythropoietin protein that aids in the formation of red blood cells, this medicine stimulates the production of this protein in the bone marrow. It may cause common side effects such as shortness of breath, cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain.
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Manufacturer/Marketer :

Concord Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Darbecon 25Mcg/0.42Ml Inj

Darbecon 25Mcg/0.42Ml Inj belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darbecon 25Mcg/0.42Ml Inj helps to reverse anaemia and reduce the need for blood transfusion. Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

Darbecon 25Mcg/0.42Ml Inj contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darbecon 25Mcg/0.42Ml Inj is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darbecon 25Mcg/0.42Ml Inj stimulates the production of this protein in the bone marrow. 

Darbecon 25Mcg/0.42Ml Inj will be injected by the healthcare provider. Do not self-administer. The most common side effects of Darbecon 25Mcg/0.42Ml Inj are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these sides effects of Darbecon 25Mcg/0.42Ml Inj do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to darbepoetin alfa or epoetin alfa, please inform your doctor before taking Darbecon 25Mcg/0.42Ml Inj to avoid any complications. Also, mention all the other medications you are taking to affect the way Darbecon 25Mcg/0.42Ml Inj works. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be signs that the body has stopped responding to Darbecon 25Mcg/0.42Ml Inj. 

Uses of Darbecon 25Mcg/0.42Ml Inj

Treatment of Anaemia (in cancer and chronic kidney disease)

Directions for Use

Darbecon 25Mcg/0.42Ml Inj will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Darbecon 25Mcg/0.42Ml Inj is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn cause low red blood cells count causing anaemia.  This medicine is primarily indicated for treating anaemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells' cancer. Darbecon 25Mcg/0.42Ml Inj contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

How Darbecon 25Mcg/0.42Ml Inj Works

Darbecon 25Mcg/0.42Ml Inj contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darbecon 25Mcg/0.42Ml Inj is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darbecon 25Mcg/0.42Ml Inj stimulates the production of this protein in the bone marrow.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Darbecon 25Mcg/0.42Ml Inj

  • Shortness of breath
  • Cough
  • Hypotension (low blood pressure)
  • Headache
  • Body aches
  • Diarrhoea
  • Injection site pain 
  • Abdominal pain (stomach pain) 

 

What if I have taken an overdose of Darbecon 25Mcg/0.42Ml Inj

Do not use more than the prescribed dose of Darbecon 25Mcg/0.42Ml Inj as it may cause overdose and lead to severe hypertension (high blood pressure). If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Darbecon 25Mcg/0.42Ml Inj can enhance the risk of serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may also shorten survival time in some people with certain types of cancer. Inform your doctor before taking Darbecon 25Mcg/0.42Ml Inj if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Darbecon 25Mcg/0.42Ml Inj if you are pregnant or breastfeeding unless prescribed by the doctor. Darbecon 25Mcg/0.42Ml Inj may affect a person's ability to drive as it may cause convulsion during initial days of treatment, so a person taking Darbecon 25Mcg/0.42Ml Inj should avoid driving or operating any machine. Darbecon 25Mcg/0.42Ml Inj should not be given to children below 12 years of age, as safety and effectiveness have not been established. Avoid consuming alcohol along with Darbecon 25Mcg/0.42Ml Inj as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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Darbepoetin alfaPomalidomide
Severe
Darbepoetin alfaThalidomide
Severe

Drug-Drug Interactions

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Darbepoetin alfaPomalidomide
Severe
How does the drug interact with Darbecon 25Mcg/0.42Ml Inj:
Taking Darbecon 25Mcg/0.42Ml Inj with Pomalidomide can increase the risk of dangerous blood clots.

How to manage the interaction:
Although there is a possible interaction between Pomalidomide and Darbecon 25Mcg/0.42Ml Inj, you can take these medicines together if prescribed by a doctor. However, If you experience chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Darbepoetin alfaThalidomide
Severe
How does the drug interact with Darbecon 25Mcg/0.42Ml Inj:
Taking thalidomide together with Darbecon 25Mcg/0.42Ml Inj may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Thalidomide and Darbecon 25Mcg/0.42Ml Inj, but it can be taken if your doctor has advised it. However, if you experience chest pain shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaCarfilzomib
Severe
How does the drug interact with Darbecon 25Mcg/0.42Ml Inj:
Combining Darbecon 25Mcg/0.42Ml Inj with Carfilzomib can increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Carfilzomib and Darbecon 25Mcg/0.42Ml Inj, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Darbepoetin alfaLenalidomide
Severe
How does the drug interact with Darbecon 25Mcg/0.42Ml Inj:
Taking Darbecon 25Mcg/0.42Ml Inj with Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Darbecon 25Mcg/0.42Ml Inj, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfil the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that give you enough energy to be active during the day; however, try to limit fats that make you fatty. Try to include olive oil, peanut oil, and corn oil into your diet.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ERYTHROPOIESIS STIMULATING AGENTS (ESAs)

Darbecon 25Mcg/0.42Ml Inj Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Darbecon 25Mcg/0.42Ml Inj as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Darbecon 25Mcg/0.42Ml Inj if you are pregnant unless prescribed by a doctor as Darbecon 25Mcg/0.42Ml Inj is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Darbecon 25Mcg/0.42Ml Inj; your doctor will decide whether Darbecon 25Mcg/0.42Ml Inj can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Darbecon 25Mcg/0.42Ml Inj causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Darbecon 25Mcg/0.42Ml Inj should not be given to children as the safety and efficacy have not been established.

FAQs

Darbecon 25Mcg/0.42Ml Inj is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darbecon 25Mcg/0.42Ml Inj helps to reverse anaemia and reduce the need for blood transfusion.
It is suggested to store the Darbecon 25Mcg/0.42Ml Inj in the refrigerator and protect it from light. However, a person should not freeze it.
It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.
A person who is allergic to any chemical compound present in Darbecon 25Mcg/0.42Ml Inj or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
Consult your doctor before taking Darbecon 25Mcg/0.42Ml Inj if you are pregnant or planning for pregnancy. Your doctor will prescribe Darbecon 25Mcg/0.42Ml Inj only if the benefits outweigh the risks.
Darbecon 25Mcg/0.42Ml Inj contains a protein "Darbepoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.
Darbecon 25Mcg/0.42Ml Inj may cause side effects such as injection site pain, cough, low blood pressure, headache, diarrhoea, body pains, shortness of breath or stomach pain. If these side effects persist or worsen, please consult your doctor.
After beginning treatment with Darbecon 25Mcg/0.42Ml Inj, it takes around 2 to 6 weeks for increase in haemoglobin level in blood.
Darbecon 25Mcg/0.42Ml Inj is used only if anaemia is due to chronic (long term) kidney disease and chemotherapy for some types of cancer (except for bone marrow and blood cells).
Darbecon 25Mcg/0.42Ml Inj may cause high blood pressure particularly in patients with long term kidney disease due to the rapid increase of red blood cells in the initial 3 months after starting Darbecon 25Mcg/0.42Ml Inj.
Darbecon 25Mcg/0.42Ml Inj is not used in the treatment of cancer. It is used in treatment of anemia (low levels of healthy red blood cells) in patients receiving chemotherapy for some types of cancer (except for bone marrow or blood cells cancer).
Darbecon 25Mcg/0.42Ml Inj should be used with extreme caution as it can cause serious side effects and can even be life-threatening. The patient should follow doctor’s recommendations strictly.
If you have deficiencies of folic acid, vitamin B12 or iron, you may not respond to Darbecon 25Mcg/0.42Ml Inj. It is important that you take measures to correct these deficiencies. Other reasons may be infections, bleeding, inflammation and bone marrow fibrosis. If you have any concerns, consult your doctor.
Darbecon 25Mcg/0.42Ml Inj is usually not recommended for children as the safety and effectiveness were not established. However, if you have any concerns regarding the use of Darbecon 25Mcg/0.42Ml Inj for children, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Survey No: 249, Brahmanapally(V), Hayathnagar(M),R.R.District, Hyderabad, Telangana, INDIA – 501511
Other Info - DAR0095

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Keep Refrigerated. Do not freeze.

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