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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:24 PM IST
D-Venizep 100 Tablet is used to treat depression. It contains clonazepam and desvenlafaxine which work by increasing the levels of chemical messengers in the brain that help maintain mental balance. In some cases, this medicine may cause side effects such as nausea, tiredness, constipation, confusion, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About D-Venizep 100 Tablet

D-Venizep 100 Tablet belongs to a group of medicines called 'antidepressants'. It is used in the treatment of depression. Depression is a common mood disorder which negatively affects a person's daily life, described as feelings of sadness, loss, or anger. Depression symptoms can vary from mild to severe and include sadness, thoughts of death or suicide, loss of interest, weight loss or gain unrelated to dieting, trouble sleeping, loss of energy, feeling worthless or guilty, and difficulty thinking.

D-Venizep 100 Tablet is a combination of two drugs: clonazepam and desvenlafaxine. Clonazepam (benzodiazepine) works by increasing levels of a calming chemical, gamma-amino-butyric acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Take D-Venizep 100 Tablet with or without food. The tablet form should be swallowed as a whole with a glass of water, do not chew or crush the tablet. In some cases, you may experience common side effects such as nausea, tiredness, constipation, confusion, insomnia (difficulty in sleeping), memory impairment, uncoordinated body movements, low sexual desire, depression, erectile dysfunction, and ejaculation disorder. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking D-Venizep 100 Tablet for as long as your doctor has prescribed. Do not take D-Venizep 100 Tablet if you are pregnant or breastfeeding unless specified by the doctor. D-Venizep 100 Tablet causes drowsiness, and sleepiness, do not drive unless you are alert. D-Venizep 100 Tablet should not be given to children and adolescents aged 18 years to treat depression. D-Venizep 100 Tablet is habit-forming so take it only if prescribed by a doctor. Avoid consuming alcohol with D-Venizep 100 Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of D-Venizep 100 Tablet

Treatment of Depression (Mood Disorder)

Medicinal Benefits

D-Venizep 100 Tablet belongs to a group of medicines called 'antidepressants', containing clonazepam and desvenlafaxine. It is used in the treatment of depression. It improves mood, helps relieve anxiety and tension, and helps you sleep better. It also prevents extreme mood changes and increases your energy level, so you do not feel low. Clonazepam increases levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of D-Venizep 100 Tablet

  • Headache
  • Nausea
  • Tiredness
  • Dry mouth
  • Constipation
  • Confusion
  • Insomnia (difficulty in sleeping)
  • Memory impairment
  • Ejaculation disorder
  • Difficulty in urination
  • Uncoordinated body movements
  • Depression
  • Erectile dysfunction
  • Low sexual desire

Drug Warnings

Do not take D-Venizep 100 Tablet if you are allergic to any ingredients present in it. Inform your doctor if you are taking antidepressants, antipsychotic medication, antihypertensives, or pain medication. Talk to your doctor if you have a history of seizures, bipolar disorder, suicide attempts, or schizophrenia. Patients with liver diseases, diabetes, heart disease, lung disease, and bleeding disorders should use D-Venizep 100 Tablet with caution. Please do not stop the treatment abruptly, as it can cause withdrawal reactions. D-Venizep 100 Tablet is not recommended for children and adolescents under 18 years of age as it increases suicidal tendencies in this population. D-Venizep 100 Tablet is habit-forming so take it only if prescribed by a doctor. Consult your doctor immediately if you experience suicidal thoughts like killing or harming yourself while on this medication. Do not take D-Venizep 100 Tablet if you are pregnant or breastfeeding unless prescribed. D-Venizep 100 Tablet causes drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with D-Venizep 100 Tablet as it could lead to increased drowsiness and dizziness.

Drug Interactions

Drug-Drug Interactions: D-Venizep 100 Tablet may have interaction with pain killers (tramadol, aspirin, acetaminophen, pethidine), narcotic pain relievers (morphine, codeine), blood thinners (warfarin), cholesterol medications (pravastatin), fits medicine (phenobarbital, phenytoin, sodium valproate, carbamazepine), anti-depression medication (aripiprazole, escitalopram), blood pressure medications (metoprolol), medications to treat stomach problems (cimetidine).

Drug-Food Interactions: Avoid consuming alcohol along with D-Venizep 100 Tablet as it may increase the sedative effects, and one can also experience impairment in thinking and judgment.

Drug-Disease Interactions: D-Venizep 100 Tablet may interact with disease conditions such as heart problems, acute alcohol intoxication, epilepsy, glaucoma, renal/liver disease, respiratory depression, and drug dependency.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • ASPIRIN
  • ACETAMINOPHEN
  • PETHIDINE
  • MORPHINE
  • CODEINE
  • PRAVASTATIN
  • PHENOBARBITAL
  • PHENYTOIN
  • SODIUM VALPROATE
  • CARBAMAZEPINE
  • ARIPIPRAZOLE
  • ESCITALOPRAM
  • METOPROLOL
  • CIMETIDINE

Habit Forming

Yes

Diet & Lifestyle Advise

  • Maintain a healthy and well-balanced diet. 
  • Do not take stress as it may aggravate your condition.
  • Limit alcohol intake and quit smoking.
  • Engage in social activities frequently as it may improve self-esteem and confidence. 
  • Limit caffeine intake.
  • Maintaining a healthy diet and exercising regularly helps improve overall health and boost self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps relieve stress, improve mood, boost self-esteem, and provide restful sleep.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Special Advise

  • D-Venizep 100 Tablet causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of D-Venizep 100 Tablet can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • D-Venizep 100 Tablet is habit-forming so take it only if prescribed by a doctor.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
  • D-Venizep 100 Tablet is unsafe for usage if you're pregnant or are planning to get pregnant. Discuss with your doctor about changing/replacing the medicine with safer alternatives.
  • To avoid getting addicted to this drug, take it in prescribed quantities and as directed by your doctor. Do not self-medicate.

Disease/Condition Glossary

Depression: It is a mood disorder characterized by sadness, unhappiness, anger, hopelessness, or loss that interferes with a person's daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

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Alcohol

Caution

Avoid consumption of alcohol while taking D-Venizep 100 Tablet as it may cause an increased sedative effect.

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Pregnancy

Unsafe

D-Venizep 100 Tablet may cause toxic effects on the fetus. So, it is not recommended for pregnant women or planning to become pregnant. Consult your doctor for further advice.

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Breast Feeding

Caution

D-Venizep 100 Tablet should be used with caution in breastfeeding mothers. Your doctor may advise you to stop breastfeeding while taking this medication.

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Driving

Caution

Do not drive or operate heavy machinery as this me D-Venizep 100 Tablet may cause drowsiness.

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Liver

Caution

D-Venizep 100 Tablet should be used with caution in patients with severe liver impairment. Dose adjustments may be required in such cases.

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Kidney

Caution

D-Venizep 100 Tablet should be used with caution in patients with kidney problems. Dose adjustments may be required in such cases. Consult the doctor if you have concerns about using D-Venizep 100 Tablet in patients with kidney problems.

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Children

Caution

D-Venizep 100 Tablet should not be used in children unless prescribed by a child specialist.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - DVE0015

Author Details

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FAQs

D-Venizep 100 Tablet is used to treat depression.
D-Venizep 100 Tablet is a combination of two drugs: clonazepam and paroxetine. Clonazepam works by increasing levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.
When you start taking D-Venizep 100 Tablet , some patients might experience increased suicidal thoughts or actions. If you feel agitated or aggressive, visit your doctor. Also, do not miss any appointment with your doctor that is scheduled.
D-Venizep 100 Tablet causes weight gain due to increased appetite and mood changes. Eat a healthy diet and exercise regularly to maintain a healthy weight.
Do not discontinue D-Venizep 100 Tablet without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually, continue taking D-Venizep 100 Tablet for as long as prescribed. Moreover, stopping this medicine suddenly may result in withdrawal symptoms. Do not be reluctant to speak with your doctor if you feel any difficulty while taking D-Venizep 100 Tablet .
D-Venizep 100 Tablet may cause decreased sex-drive, problems with erection, and orgasm. Consult your doctor if you have any concerns regarding this.
D-Venizep 100 Tablet may cause drowsiness. Avoid activities requiring full attention, such as driving, and operating machinery while using this medication. Abruptly stopping D-Venizep 100 Tablet may result in significant withdrawal symptoms. Therefore, consult your doctor to gradually reduce the dosage before discontinuing use. This medication is habit-forming, so use it only exactly as prescribed by your doctor. Avoid alcohol consumption while taking D-Venizep 100 Tablet , as it may cause severe side effects. D-Venizep 100 Tablet is not safe for use during pregnancy or if you are planning to conceive. Discuss with your doctor about changing/replacing the medicine with safer alternatives. To prevent dependency, take the medication strictly as directed by your doctor and avoid self-medication.
D-Venizep 100 Tablet may cause weight gain due to increased appetite and mood changes. If you notice any weight changes, exercise regularly, stay hydrated, eat nutritious-rich food, get enough sleep, cut down on carbs and processed foods, reduce your intake of sugary beverages, and eat fibre-rich food.
Yes, D-Venizep 100 Tablet may cause sleepiness as a common side effect. If you experience sleepiness, avoid driving or operating heavy machinery until you are fully alert.
Yes, D-Venizep 100 Tablet may cause low sexual desire, erectile dysfunction, and ejaculation disorder. Consult the doctor if you notice any of these symptoms.
No, you should not drink alcohol while taking D-Venizep 100 Tablet as it may lead to increased drowsiness or dizziness. Always consult the doctor for specific guidance based on your condition.
D-Venizep 100 Tablet may take several weeks to show noticeable improvement in symptoms. However, the time can vary depending on the individual and the condition being treated. Therefore, always follow your doctor's guidance and continue taking the medication exactly as prescribed for best results.
D-Venizep 100 Tablet should be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.

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