Cyramza 500 Injection is an anti-cancer medicine used alone or in combination with other combination medicines for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma, hepatocellular cancer, colorectal cancer, and non-small cell lung cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Cyramza 500 Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Cyramza 500 Injection may cause some side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Cyramza 500 Injection will be administered by a doctor experienced in the administration of cancer medicine. Do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Cyramza 500 Injection or its components. Inform your doctor if you have any cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver/kidney disease, as it can cause adverse effects. Cyramza 500 Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Cyramza 500 Injection contains Trastuzumab, which is used for treating patients with different types of cancer. This medicine works by inhibiting the excess production of a human vascular endothelial growth factor receptor 2, which is responsible for the growth and spread of cancer cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

• Nausea
• Vomiting
• Diarrhoea
• Nose bleeds
• Headache
• Fatigue
• Injection site reactions
• Pain at the site of injection
• Increased blood pressure
• Dry mouth
• Mouth sores
• Fever
• Back pain

Cyramza 500 Injection should be avoided if you are allergic to it or any other components of this medicine. Before taking Cyramza 500 Injection, inform your doctor if you have any history of cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver or kidney disease, as it can cause adverse effects. Cyramza 500 Injection may cause Cyramza 500 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, an increased risk of hemorrhage, infusion-related reactions, gastrointestinal perforation, and clinical deterioration in patients with cirrhosis during the treatment. Hence, careful observation should be performed for any reactions in the patient. Cyramza 500 Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Cyramza 500 Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions: Cyramza 500 Injection may interact with monoclonal antibodies (etanercept, golimumab, infliximab, natalizumab, abciximab), antiviral drugs (indinavir, efavirenz, atazanavir), anticoagulants (apixaban, dicumarol), etc.

Drug-Food Interactions: No interaction found.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, lung disease, liver/kidney disease or allergic reactions.

• ATAZANAVIR
• NATALIZUMAB
• ETANERCEPT

• Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
• Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
• Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
• Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
• Avoid smoking and alcohol consumption.

• Avoid intercourse while on treatment with Cyramza 500 Injection.
• Regular, complete blood count monitoring is advised during the treatment.
• Liver function tests (LFT) and kidney function tests (RFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
• Regular ECG, blood pressure, and electrolytes should be monitored while taking the medicine.

Stomach Cancer (Gastric adenocarcinoma) is a type of cancer that develops from the stomach lining. When the cancer cells spread to other organs of the body, it is called metastatic. This condition can occur mainly due to smoking, a highly processed or salty diet, and severe bacterial infection of H. pylori. Symptoms of stomach cancer include feeling bloated after eating, feeling full after eating small amounts of food, nausea, heartburn or indigestion.

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing.

Hepatocellular carcinoma: It occurs when the cancer/ malignant cells grow out of control in the liver. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Colorectal cancer: Also known as colon cancer (growth of cancer cells in the colon) or rectal cancer (cancer cells grow in the rectum area), is a condition in which the cancerous or malignant cells grow out of control in the colon or rectum. Symptoms may include diarrhoea, constipation, bloody stools, change in bowel habits, abdominal discomfort, etc.