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  3. Cyramza 100 Injection 10 ml

Cyramza 100 Injection 10 ml, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cyramza 100 Injection is used for treating Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer. It contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death. Thus, it treats certain cancers. Cyramza 100 Injection may cause side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions.

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Composition :

RAMUCIRUMAB-100MG

Manufacturer/Marketer :

Eli Lilly and Company (India) Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cyramza 100 Injection

Cyramza 100 Injection is an anti-cancer medicine used alone or in combination with other combination medicines for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma, hepatocellular cancer, colorectal cancer, and non-small cell lung cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Cyramza 100 Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Cyramza 100 Injection may cause some side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Cyramza 100 Injection will be administered by a doctor experienced in the administration of cancer medicine. Do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Cyramza 100 Injection or its components. Inform your doctor if you have any cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver/kidney disease, as it can cause adverse effects. Cyramza 100 Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Cyramza 100 Injection

Treatment of Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer

Directions for Use

A doctor who is trained or experienced in the administration of chemotherapeutic agents will administer Cyramza 100 Injection. Do not self-administer.

Medicinal Benefits

Cyramza 100 Injection contains Trastuzumab, which is used for treating patients with different types of cancer. This medicine works by inhibiting the excess production of a human vascular endothelial growth factor receptor 2, which is responsible for the growth and spread of cancer cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

How Cyramza 100 Injection Works

Cyramza 100 Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cyramza 100 Injection 10 ml
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.

What if I have taken an overdose of Cyramza 100 Injection

As Cyramza 100 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Cyramza 100 Injection should be avoided if you are allergic to it or any other components of this medicine. Before taking Cyramza 100 Injection, inform your doctor if you have any history of cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver or kidney disease, as it can cause adverse effects. Cyramza 100 Injection may cause Cyramza 100 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, an increased risk of hemorrhage, infusion-related reactions, gastrointestinal perforation, and clinical deterioration in patients with cirrhosis during the treatment. Hence, careful observation should be performed for any reactions in the patient. Cyramza 100 Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Cyramza 100 Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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RamucirumabDiclofenac
Severe
RamucirumabKetorolac
Severe

Drug-Drug Interactions

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RamucirumabDiclofenac
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Co-administration of Diclofenac and Cyramza 100 Injection 10 ml can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Diclofenac and Cyramza 100 Injection 10 ml can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
RamucirumabKetorolac
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Coadministration of ketorolac with Cyramza 100 Injection 10 ml can cause bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Cyramza 100 Injection 10 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
RamucirumabPrasugrel
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Co-administration of Prasugrel with Cyramza 100 Injection 10 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Cyramza 100 Injection 10 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabApixaban
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Using Cyramza 100 Injection 10 ml together with apixaban may increase the risk of bleeding.

How to manage the interaction:
Even though combining Cyramza 100 Injection 10 ml and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
RamucirumabClopidogrel
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
The use of Cyramza 100 Injection 10 ml together with clopidogrel may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Clopidogrel and Cyramza 100 Injection 10 ml, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
RamucirumabDabigatran etexilate
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Taking Dabigatran etexilate with Cyramza 100 Injection 10 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cyramza 100 Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabFondaparinux
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Using Cyramza 100 Injection 10 ml together with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Fondaparinux and Cyramza 100 Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
RamucirumabAspirin
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Combined use of aspirin with Cyramza 100 Injection 10 ml may result in gut ulcers and bleeding.

How to manage the interaction:
There may be a possibility of interaction between Aspirin and Cyramza 100 Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you notice unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
RamucirumabPiroxicam
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Coadministration of Piroxicam with Cyramza 100 Injection 10 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Piroxicam with Cyramza 100 Injection 10 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

It is unknown whether Cyramza 100 Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Cyramza 100 Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cyramza 100 Injection. You should not become pregnant while you are receiving Cyramza 100 Injection for at least three months from the last dose of Cyramza 100 Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Cyramza 100 Injection should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least two months from the last dose of medicine.

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Driving

Caution

Cyramza 100 Injection will be administered to hospitalized patients. Driving is not recommended.

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Liver

Safe if prescribed

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Cyramza 100 Injection. Based on population PK analysis, no dose adjustment is advised for patients with mild liver impairment. Patients with Child-Pugh B or C cirrhosis who received single-agent Cyramza 100 Injection reported clinical deterioration.

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Kidney

Safe if prescribed

Hence, if you have a pre-existing or a history of kidney disease, inform your doctor. Based on population PK analysis, no dose adjustment is advised for patients with kidney impairment.

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Children

Unsafe

Cyramza 100 Injection is not recommended for use in children as the safety and efficacy are not established.

Have a query?

FAQs

Cyramza 100 Injection is used to treat Colorectal Cancer, Stomach Cancer, Hepatocellular cancer and Non-small cell lung cancer.

Cyramza 100 Injection contains Ramucirumab, which works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Inform your doctor whether you have received any other cancer treatment. Cyramza 100 Injection may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, infusion-related reactions, gastrointestinal perforation, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Cyramza 100 Injection.

Country of origin

India

Manufacturer/Marketer address

Plot# 92, Sector 32, Institutional Area, Gurgaon-122001, Haryana, India
Other Info - CYR0010

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.drugs.com/mtm/ramucirumab.html
  2. https://www.cyramza.com/mcrc
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/125477s002lbl.pdf
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