CTX-GLS 500 Injection

CTX-GLS 500 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, CTX-GLS 500 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
CTX-GLS 500 Injection contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, CTX-GLS 500 Injection helps treat cancer. CTX-GLS 500 Injection suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, CTX-GLS 500 Injection may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. CTX-GLS 500 Injection may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

CTX-GLS 500 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. CTX-GLS 500 Injection works by stopping or slowing the growth of cancer cells in the body. Thereby, CTX-GLS 500 Injection helps treat cancer. Additionally, CTX-GLS 500 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. CTX-GLS 500 Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.

• Nausea
• Vomiting
• Stomatitis (inflamed and sore mouth)
• Weakness
• Malaise (general discomfort)
• Fever
• Leukopenia (low white blood cell count)
• Alopecia (hair loss)

Do not take CTX-GLS 500 Injection if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. CTX-GLS 500 Injection may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Drug-Drug Interactions: CTX-GLS 500 Injection may have interaction with protease inhibitors, ACE inhibitors, immunomodulators (natalizumab), chemotherapy agents (paclitaxel), thiazide diuretics, anti-HIV (zidovudine), antiarrhythmics (amiodarone), anti-fungal (amphotericin B), NSAID (indomethacin), immunosuppressant (azathioprine), alkylating agents (busulfan).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow or obstruction.

• NATALIZUMAB
• PACLITAXEL
• ZIDOVUDINE
• AMIODARONE
• AMPHOTERICIN B
• INDOMETHACIN
• AZATHIOPRINE
• BUSULFAN

• Eat a healthy diet and exercise regularly to maintain proper weight.
• Avoid smoking and alcohol consumption.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
• Avoid fast food, fried food, processed meats, refined carbs and added sugar.
• Get optimal sleep; rest well.

• Monitoring of complete blood count whilst on treatment with CTX-GLS 500 Injection is advised.
• Women of childbearing potential must use highly effective contraception during treatment and for up to 1 year after the last dose.
• Male patients who are sexually active with a female partner of child-bearing potential must use condoms during treatment and for up to 6 months after the last dose.

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner leading to the formation of tumours. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder in which the body excretes too much protein in the urine. Symptoms include foamy urine, weight gain, and swelling around the eyes and in the ankles and feet.