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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cregnex 500k Injection is used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. It contains Polymyxin B, which destroys bacterial cell membranes and kills infection-causing bacteria. Thereby, it helps treat bacterial infections. In some cases, Cregnex 500k Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea.

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Whats That

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Synonym :

POLYMYXIN B SULPHATE

Manufacturer/Marketer :

Converge Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cregnex 500k Injection

Cregnex 500k Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms.

Cregnex 500k Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

In some cases, Cregnex 500k Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in Cregnex 500k Injection. Consult the doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Cregnex 500k Injection

Treatment of Bacterial infections

Directions for Use

Cregnex 500k Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Cregnex 500k Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. Cregnex 500k Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

How Cregnex 500k Injection Works

Cregnex 500k Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Cregnex 500k Injection

As Cregnex 500k Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not receive Cregnex 500k Injection if you are allergic to any of its components. Consult the doctor if you are pregnant or breastfeeding. Seek medical attention if you experience symptoms of kidney problems (unable to pass urine, change in how much urine you pass), nerve problems (weakness, irritation, feeling sleepy, blurred eyesight, change in balance, numbness or tingling around the mouth or in the arms or legs, or trouble breathing), or Clostridium difficile associated diarrhoea/CDAD (stomach pain, cramps, very loose, watery, or bloody stool). Let the doctor know if you are taking any prescription/non-prescription medicines, including supplements or herbal products.

Drug-Drug Interactions

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Polymyxin bCholera, live attenuated
Severe

Drug-Drug Interactions

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Polymyxin bCholera, live attenuated
Severe
How does the drug interact with Cregnex 500K Injection:
Taking Cregnex 500K Injection and Cholera together may lead to a decrease in the effectiveness of the vaccine.

How to manage the interaction:
There may be a possibility of interaction between Cregnex 500K Injection and Cholera, live attenuated, but it can be taken if prescribed by a doctor. It is advised not to receive the cholera vaccination until at least 14 days after finishing your Cregnex 500K Injection therapy in order to ensure an appropriate immune response. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Cregnex 500K Injection:
Coadministration of Amikacin with Cregnex 500K Injection may increase the risk of severe side effects.

How to manage the interaction:
Although taking Amikacin and Polymyxin- b together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience ringing in the ears, difficulty breathing, vomiting, irregular urination, swelling, muscle pain, dizziness, or palpitation. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cregnex 500K Injection:
Using Cregnex 500K Injection together with streptomycin can increase the risk or severity of developing hearing loss, breathing problems, and kidney problems.

How to manage the interaction:
Although taking Cregnex 500K Injection and Streptomycin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, hearing loss, ringing in the ears, vertigo, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Cregnex 500K Injection:
Co-administration of Cregnex 500K Injection and Vecuronium together may cause serious breathing problems.

How to manage the interaction:
Taking Cregnex 500K Injection with Vecuronium together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any breathing difficulty, consult the doctor. Do not stop using any medications without a doctor's advice.
Polymyxin bTubocurarine
Severe
How does the drug interact with Cregnex 500K Injection:
Co-administration of Cregnex 500K Injection and Tubocurarine together may cause serious breathing problems.

How to manage the interaction:
There may be a possibility of interaction between Cregnex 500K Injection and Tubocurarine, but it can be taken if prescribed by a doctor. However, if you experience any breathing difficulty, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cregnex 500K Injection:
Co-administration of Deferasirox and Cregnex 500K Injection may increase the risk of kidney problems.

How to manage the interaction:
Although taking Cregnex 500K Injection and Deferasirox together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, swelling, breathing difficulty, bone pain, muscle pain, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
Polymyxin bBacitracin
Severe
How does the drug interact with Cregnex 500K Injection:
Taking Cregnex 500K Injection and Bacitracin together can increase the risk of kidney and inner ear damage

How to manage the interaction:
Although taking Cregnex 500K Injection and Bacitracin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience ringing in the ears, hearing loss, vertigo, nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
Polymyxin bIodamide
Severe
How does the drug interact with Cregnex 500K Injection:
Co-administration of Iodamide with Cregnex 500K Injection may increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Cregnex 500K Injection and Iodamide, you can take these medicines together if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pain, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cregnex 500K Injection:
When Neomycin and Cregnex 500K Injection are taken together, there is an increased possibility of severe side effects.

How to manage the interaction:
Taking Cregnex 500K Injection with Neomycin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, hearing loss, ringing in the ears, vertigo, consult a doctor. Do not discontinue any medications without a doctor's advice.
Polymyxin bBCG vaccine
Severe
How does the drug interact with Cregnex 500K Injection:
When the BCG vaccine is used with Cregnex 500K Injection, its effectiveness may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Cregnex 500K Injection and BCG vaccine, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include whole grains, fruits, and vegetables in your diet. 
  • Taking probiotics after antibiotic treatment and eating high-fibre and prebiotic foods may help reduce side effects and support digestion.
  • Exercising regularly helps in improving overall health. 
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress.
  • Avoid processed and fried food.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Cregnex 500k Injection. Please consult the doctor.

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Pregnancy

Caution

The safety of polymyxin B in pregnancy has not been established. If you are pregnant or planning pregnancy, inform the doctor before receiving Cregnex 500k Injection.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Cregnex 500k Injection. Caution is advised while administering Cregnex 500k Injection to lactating women.

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Driving

Consult your doctor

It is unknown if Cregnex 500k Injection affects your ability to drive. Drive only if you are alert.

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Liver

Consult your doctor

If you have a history of liver problems, inform the doctor before receiving Cregnex 500k Injection.

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Kidney

Caution

If you have a history of kidney problems, inform the doctor before receiving Cregnex 500k Injection.

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Children

Safe if prescribed

Cregnex 500k Injection may be safe for use in children if prescribed by the doctor.

Have a query?

FAQs

Cregnex 500k Injection is used to treat Bacterial infections.

Cregnex 500k Injection works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Diarrhoea might be a side effect of Cregnex 500k Injection. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult the doctor if the condition persists or worsens.

Cregnex 500k Injection may cause nerve problems. Consult the doctor if you experience weakness, irritation, change in balance, feeling sleepy, blurred eyesight, trouble breathing, numbness or tingling sensation in the arms and legs.

Cregnex 500k Injection will be administered by a healthcare professional. Do not self-administer.

Yes, Cregnex 500k Injection is safe when used only under the doctor’s supervision. However, it may cause pain at the injection site, flushing, dizziness, and diarrhoea while using it.

The common side effects of Cregnex 500k Injection may include pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

7-2-1813,/5/A/1, Vasavi's Central Court, Unit-II , 3rd Floor, Czech Colony, Sanath Nagar, Hyderabad - 500018., Telangana state, India.
Other Info - CRE0228

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