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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
COTRIZINE DS TABLETS is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). It contains Trimethoprim and Sulfamethoxazole, which stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections. In some cases, you may experience certain common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

AAA Pharma Trade Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About COTRIZINE DS TABLETS

COTRIZINE DS TABLETS is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. COTRIZINE DS TABLETS does not work against infections caused by the virus, including cold and flu. 

COTRIZINE DS TABLETS is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, COTRIZINE DS TABLETS stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Your doctor will decide the dose and duration of COTRIZINE DS TABLETS based on your condition and the severity of the infection. In some cases, you may experience certain common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting COTRIZINE DS TABLETS , please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take COTRIZINE DS TABLETS on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking COTRIZINE DS TABLETS if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. COTRIZINE DS TABLETS is not recommended for children below 12 years.

Uses of COTRIZINE DS TABLETS

Treatment of Bacterial infections.

Directions for Use

Swallow COTRIZINE DS TABLETS as a whole with water; do not crush or chew it.

Medicinal Benefits

COTRIZINE DS TABLETS belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). COTRIZINE DS TABLETS is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, COTRIZINE DS TABLETS kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. COTRIZINE DS TABLETS is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

How COTRIZINE DS TABLETS Works

COTRIZINE DS TABLETS is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, COTRIZINE DS TABLETS stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of COTRIZINE DS TABLETS

  • High levels of potassium in the blood
  • Palpitations (abnormal heartbeats)
  • Thrush or candidiasis (fungal infection)
  • Headache
  • Nausea
  • Diarrhoea
  • Skin rashes

What if I have taken an overdose of COTRIZINE DS TABLETS

Do not take more than the prescribed dose of COTRIZINE DS TABLETS as it may cause overdose. The symptoms of overdose include headache, dizziness, nausea, vomiting, confusion, loss of appetite, drowsiness, or mental depression. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take COTRIZINE DS TABLETS if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking COTRIZINE DS TABLETS if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking COTRIZINE DS TABLETS to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
TrimethoprimAmiloride
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Cotrizine DS Tablet 10's:
Taking Cotrizine DS Tablet 10's with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Cotrizine DS Tablet 10's and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimAmiloride
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
When amiloride is taken with Cotrizine DS Tablet 10's it may raise potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm).

How to manage the interaction:
Although there is an interaction between amiloride and Cotrizine DS Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse. Do not discontinue any medications without consulting a doctor.
TrimethoprimAzilsartan medoxomil
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Coadministration of Azilsartan medoxomil with Cotrizine DS Tablet 10's may increase potassium levels in the blood.

How to manage the interaction:
Although there is an interaction between azilsartan medoxomil and Cotrizine DS Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience vomiting, weakness, or tingling in your hands and feet. Do not discontinue any medications without a doctor's advice.
TrimethoprimMethotrexate
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Coadministration of Cotrizine DS Tablet 10's with methotrexate can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between Cotrizine DS Tablet 10's and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
TrimethoprimOlmesartan medoxomil
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Taking olmesartan medoxomil with Cotrizine DS Tablet 10's may increase potassium levels in the blood.

How to manage the interaction:
Although taking olmesartan medoxomil with Cotrizine DS Tablet 10's may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
TrimethoprimIvacaftor
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
When Cotrizine DS Tablet 10's is taken with Ivacaftor, the amount of Cotrizine DS Tablet 10's in the blood increases.

How to manage the interaction:
Taking Cotrizine DS Tablet 10's with Ivacaftor together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting your doctor.
TrimethoprimRamipril
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Taking Ramipril with Cotrizine DS Tablet 10's can increase the potassium levels in the blood, increasing the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between ramipril and Cotrizine DS Tablet 10's, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting your doctor.
TrimethoprimRopivacaine
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Using ropivacaine with Cotrizine DS Tablet 10's can cause higher levels of Cotrizine DS Tablet 10's in the blood.

How to manage the interaction:
Although taking Ropivacaine and Cotrizine DS Tablet 10's together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimethoprimPotassium acetate
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Taking potassium acetate with Cotrizine DS Tablet 10's may increase potassium levels in the blood which can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Cotrizine DS Tablet 10's and Potassium acetate, you can take these medicines together if prescribed by your doctor. However, if you have unusual symptoms contact your doctor right away. Do not discontinue any medications without consulting your doctor.
TrimethoprimBenazepril
Severe
How does the drug interact with Cotrizine DS Tablet 10's:
Taking Cotrizine DS Tablet 10's with Benazepril can cause high levels of potassium in the blood.

How to manage the interaction:
Although there is an interaction between benazepril and Cotrizine DS Tablet 10's, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

COTRIZINE DS TABLETS Substitute

Substitutes safety advice
  • Bactrim DS Tablet 10's

    2.30per tablet
  • Celtrim-Ds Tablet 10's

    by AYUR

    2.52per tablet
  • Jolltrim DS Tablet 10's

    2.52per tablet
  • Oriprim Ds Tablet 10's

    2.30per tablet
  • Sepmax Tablet 10's

    8.78per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while taking COTRIZINE DS TABLETS to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

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Pregnancy

Caution

Please consult your doctor before taking COTRIZINE DS TABLETS if you are pregnant. Your doctor will prescribe COTRIZINE DS TABLETS only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding, your doctor will prescribe COTRIZINE DS TABLETS only if the benefits outweigh the risks.

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Driving

Caution

It is unknown whether COTRIZINE DS TABLETS affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed.

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Liver

Caution

Please consult your doctor before taking COTRIZINE DS TABLETS if you have liver impairment/liver disease. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

COTRIZINE DS TABLETS to be taken with caution, especially if you have a history of kidney impairment/kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

COTRIZINE DS TABLETS is not recommended for children below 12 years.

FAQs

COTRIZINE DS TABLETS is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).
COTRIZINE DS TABLETS is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, COTRIZINE DS TABLETS kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.
COTRIZINE DS TABLETS causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.
Diarrhoea might be a side-effect of COTRIZINE DS TABLETS . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking COTRIZINE DS TABLETS and consult your doctor. Do not take anti-diarrheal medicine on your own.
It is recommended to complete the course of COTRIZINE DS TABLETS even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking COTRIZINE DS TABLETS for as long as your doctor has prescribed to treat your condition effectually.
Do not take COTRIZINE DS TABLETS on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.
COTRIZINE DS TABLETS may affect certain laboratory test results. Inform the person doing the tests that you are taking COTRIZINE DS TABLETS .
COTRIZINE DS TABLETS may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking COTRIZINE DS TABLETS .
You can take COTRIZINE DS TABLETS with or without as advised by your doctor. Take COTRIZINE DS TABLETS preferably with food to avoid nausea or diarrhoea.
No, COTRIZINE DS TABLETS is not an addiction causing medicine. But the dose and duration should be followed as prescribed by your doctor.
Yes, COTRIZINE DS TABLETS can be used for urinary tract infection as COTRIZINE DS TABLETS is used to prevent infections caused by bacteria.
Pimples are caused due to various reasons. Therefore, please consult your doctor before taking COTRIZINE DS TABLETS . If you have any concerns regarding acne, discuss with your doctor.
Yes, COTRIZINE DS TABLETS is a stronger antibiotic. It contains two antibiotics namely, Sulfamethoxazole and Trimethoprim.
COTRIZINE DS TABLETS can cause side effects such as high levels of potassium in your blood, which can cause abnormal heart beats. Also, it may cause fungal infections like thrush or candidiasis which can affect mouth or vagina and other common side effects like headache, nausea, diarrhoea and skin rashes. If these effects worsen or persist, consult your doctor.
Yes, COTRIZINE DS TABLETS is safe to use in most patients. However consult your doctor if you experience any side effects like nausea, vomiting, skin rash, allergic reaction.
Yes, COTRIZINE DS TABLETS can cause nausea and vomiting. If these persist or worsen, consult your doctor.
COTRIZINE DS TABLETS is contraindicated in patients who have a history of drug-induced immune thrombocytopenia from using trimethoprim and/or sulfonamides, who have a known hypersensitivity to these medications, or who have megaloblastic anemia from a folate deficiencies and in patients with severe renal insufficiency or obvious liver impairment.
Avoid spicy, acidic, and greasy foods while taking COTRIZINE DS TABLETS as they may increase your risk of side effects such upset stomach and diarrhoea. Also, COTRIZINE DS TABLETS can interact with alcohol. It's best to avoid drinking alcohol while taking COTRIZINE DS TABLETS .
Yes, COTRIZINE DS TABLETS expires. The expiry date can be found on the packaging.
No, do not stop taking COTRIZINE DS TABLETS without first consulting your doctor. Complete the full course of treatment even if you feel better as you may notice an improvement in your symptoms before the infection is cured completely.
If you miss a dose of COTRIZINE DS TABLETS , do not worry. Take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.
If you don't feel better after completing the full course of treatment with COTRIZINE DS TABLETS , inform your doctor. Also, let your doctor know if your symptoms are worsening while taking COTRIZINE DS TABLETS .
COTRIZINE DS TABLETS should be used in children above 12 years of age if advised by a doctor.
Avoid taking COTRIZINE DS TABLETS if you are allergic to Sulfamethoxazole, Trimethoprim or any other ingredients of COTRIZINE DS TABLETS . If you have severe liver or kidney problems, or have ever had thrombocytopenia (blood problem causing bleeding or bruises) or have porphyria (a rare blood problem), inform your doctor before taking COTRIZINE DS TABLETS .
Take COTRIZINE DS TABLETS as advised by your doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose. Swallow it as whole with a glass of water. Do not crush or chew it.
Store the COTRIZINE DS TABLETS in the original package at room temperature. Keep it out of the reach and sight of children.

Country of origin

India

Manufacturer/Marketer address

E-11, MOTI NAGAR , NEW DELHI-110015
Other Info - COT0176

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