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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:37 PM IST
Combigan Ophthalmic Solution 5 ml is used to lower intraocular pressure in conditions like glaucoma and ocular hypertension. It works by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. In some cases, this medicine may cause side effects such as a burning sensation, eye redness, itching, irritation, and vision disturbances. Avoid touching the container's tip to the eye, eyelids, or surrounding areas as it may contaminate the product.
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Consume Type

OPHTHALMIC

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Combigan Ophthalmic Solution 5 ml

Combigan Ophthalmic Solution 5 ml is used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). 
 
Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate (alpha-2 adrenergic receptor agonists), Timolol (beta-blocker), and Benzalkonium chloride (preservative). Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye. 
 
You are advised to use Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side effects such as a burning sensation, eye redness, itching, irritation, and vision disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years as safety and effectiveness have not been established. Combigan Ophthalmic Solution 5 ml might cause drowsiness, so drive only if you are alert. Avoid touching the tip of the dropper as it may contaminate the contents. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Combigan Ophthalmic Solution 5 ml

Treatment of Glaucoma and ocular hypertension

Medicinal Benefits

Combigan Ophthalmic Solution 5 ml is a combination of three drugs: Brimonidine tartrate, Timolol, and Benzalkonium chloride. Combigan Ophthalmic Solution 5 ml is indicated for lowering intraocular pressure in patients with glaucoma or ocular hypertension. Brimonidine tartrate belongs to a group of medicines called alpha-2 adrenergic receptor agonists, and Timolol belongs to a group of medicines called beta-blockers. They work by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

Directions for Use

Lie down and tilt your head backwards. Pull your lower eyelid gently with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Combigan Ophthalmic Solution 5 ml

  • Burning sensation
  • Eye redness
  • Eye itching
  • Irritation
  • Vision disturbances

Drug Warnings

Do not use Combigan Ophthalmic Solution 5 ml if you are allergic to any of its contents, if you have/had bronchial asthma, severe chronic obstructive bronchitis, low heart rate, heartbeat disorder, heart failure, if you are taking anti-depressants or monoamine oxidase inhibitors. Inform your doctor if you have/had coronary heart disease, slow heartbeat, breathing problems, chronic obstructive pulmonary disease, poor blood circulation disease, diabetes, overactive thyroid, tumour of the adrenal gland, corneal disease, excess acidity in the blood, kidney or liver problems. If you are due to have any surgery or eye surgery, inform the doctor/surgeon that you are taking Combigan Ophthalmic Solution 5 ml. Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years. Combigan Ophthalmic Solution 5 ml might cause drowsiness, blurred vision; so, drive only if you are alert. 

Drug Interactions

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Habit Forming

No

Diet & Lifestyle Advise

  • Include fresh fruits and vegetables in your diet.

  • Avoid smoking and alcohol consumption.

  • Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as french fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.

  • Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.

  • Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

Disease/Condition Glossary

Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms of glaucoma initially, except the slow loss of vision gradually. However, some symptoms include visible rainbow-coloured circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance or nausea.

Ocular hypertension: It is a condition caused by poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). This leads to a build-up of excess fluid in the eye, resulting in increased pressure inside the eye. If ocular hypertension is not controlled, it may lead to glaucoma.

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Alcohol

Caution

It is not known if alcohol interacts with Combigan Ophthalmic Solution 5 ml. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding. Your doctor will decide if Combigan Ophthalmic Solution 5 ml can be used by breastfeeding mothers or not.

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Driving

Caution

Combigan Ophthalmic Solution 5 ml might cause tiredness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with kidney impairment.

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Children

Unsafe

Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years as safety and effectiveness have not been established.

Country of origin

INDIA

Manufacturer/Marketer address

No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore – 560 001., KARNATAKA, INDIA
Other Info - COM0005

Author Details

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FAQs

Combigan Ophthalmic Solution 5 ml is indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension.
Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.
Do not stop using Combigan Ophthalmic Solution 5 ml without consulting your doctor. Continue using Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it to you to treat your condition effectually. Consult the doctor if you experience any difficulty while using Combigan Ophthalmic Solution 5 ml.
Combigan Ophthalmic Solution 5 ml might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.
Combigan Ophthalmic Solution 5 ml contains benzalkonium chloride; it might discolour soft contact lenses. Therefore, do not wear contact lens while using Combigan Ophthalmic Solution 5 ml. Remove contact lenses before using Combigan Ophthalmic Solution 5 ml and put them back 15 minutes after using Combigan Ophthalmic Solution 5 ml.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you have hypertension. Regularly monitor blood pressure levels while taking Combigan Ophthalmic Solution 5 ml to prevent unpleasant events.
Dry mouth could be a side-effect of Combigan Ophthalmic Solution 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Combigan Ophthalmic Solution 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Combigan Ophthalmic Solution 5 ml and other eye medications.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you are diabetic as Combigan Ophthalmic Solution 5 ml contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Combigan Ophthalmic Solution 5 ml is advised.

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