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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Combee-L Tablet is a contraceptive medicine used in the prevention of unwanted pregnancy and treatment of menorrhagia, and acne. This medicine inhibits the release of potent eggs from the ovary, thus preventing pregnancy. Common side effects include nausea, breast soreness, headache and dizziness. This medicine is intended for women's use; hence, it is not recommended for the male population, children, pregnant women, and breastfeeding women.

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Manufacturer/Marketer :

Dewcare Concept Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Combee-L Tablet

Combee-L Tablet belongs to a group of medications called 'hormonal contraceptives' primarily used for contraception and in treating dysmenorrhea (irregular and painful periods). Contraception is a procedure that aims to prevent unwanted pregnancy for safe family planning. Dysmenorrhea is an irregular and painful menstrual period, that leads to abdominal pain, mood swings, digestion problems, fainting, vomiting, and nausea.

Combee-L Tablet is a combination of two medications: Ethinyloestradiol and Levonorgestrel. Combee-L Tablet prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). Combee-L Tablet may also change the lining of the uterus to prevent the development of a pregnancy. Thus, Combee-L Tablet helps prevent pregnancy.

Take Combee-L Tablet as prescribed by your doctor. In some cases, Combee-L Tablet may cause stomach pain, headache, nausea, breast pain, weight gain, and mood swings. Most of these side effects of Combee-L Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Inform your doctor before starting Combee-L Tablet if you are over 35 years or ever have a heart problem, cancer (breast, uterus, or vagina), uterine bleeding, liver, or kidney problems. Do not take Combee-L Tablet if you are pregnant or breastfeeding. Combee-L Tablet does not prevent the transmission of any sexually transmitted diseases (STD), so use other forms of contraception (condom) during sexual intercourse if you have any STD or AIDS (acquired immunodeficiency syndrome).

Uses of Combee-L Tablet

Contraception and treatment of Dysmenorrhea (irregular menstrual periods)

Directions for Use

Combee-L Tablet is an oral contraceptive pill preferably taken with or without food. It should be taken simultaneously every day for the best results. Combee-L Tablet is generally prescribed for 21 days starting from the first day of your menstrual cycle. Should not take it for the remaining seven days afterwards. The course will remain the same every month.

Medicinal Benefits

Combee-L Tablet is an oral hormonal combination drug primarily used for contraception. Combee-L Tablet contains two female sex hormones, progestin (levonorgestrel) and estrogen (ethinyloestradiol), which help prevent pregnancy in multiple ways. It prevents the release of an egg from the ovaries and makes the fluid present in the cervix thicker, making it difficult for sperm to enter the womb. In addition to this, it prevents the thickening of the uterus's inner wall, which is necessary for an egg to grow. Thereby, Combee-L Tablet helps prevent pregnancy.

How Combee-L Tablet Works

Combee-L Tablet is a combination of two medications: Ethinyloestradiol and Levonorgestrel. Combee-L Tablet prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). Combee-L Tablet may also change the lining of the uterus to prevent the development of a pregnancy. Thus, Combee-L Tablet helps prevent pregnancy.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Combee-L Tablet

  • Headache
  • Weight gain
  • Acne (pimples)
  • Stomach pain/cramps
  • Tiredness
  • Depression

What if I have taken an overdose of Combee-L Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, and drowsiness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Please inform your doctor if you have/had heart disease, hypertension, obesity, cancer (breast, cervix, or uterus), diabetes mellitus, liver or kidney disease, or abnormal uterine bleeding. Smoking may increase the risk of cardiovascular events in women over 35 years old when taking Combee-L Tablet . Combee-L Tablet does not protect against any sexually transmitted disease or HIV. If pregnancy occurs while you are taking Combee-L Tablet , please consult your doctor. Do not start using a new medication without telling your doctor. Sometimes, you may experience spotting or bleeding in between missed periods or menstrual periods. If the spotting persists, please consult your doctor. Do not use Combee-L Tablet if you are pregnant or have recently delivered a baby. If you have missed a dose or are late by 12 hours, use a condom for two days during sexual intercourse to avoid unwanted pregnancy. Do not take Combee-L Tablet if you are pregnant or breastfeeding. If you have migraines, please inform your doctor, as taking Combee-L Tablet may increase your headache.

Drug-Drug Interactions

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LevonorgestrelEtretinate
Critical
LevonorgestrelTranexamic acid
Critical

Drug-Drug Interactions

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LevonorgestrelEtretinate
Critical
How does the drug interact with Combee-L Tablet 21's:
Using etretinate and Combee-L Tablet 21's can cause severe birth defects.

How to manage the interaction:
Taking Etretinate with Combee-L Tablet 21's can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
LevonorgestrelTranexamic acid
Critical
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's with Tranexamic acid may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Tranexamic acid with Combee-L Tablet 21's may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LevonorgestrelAcitretin
Critical
How does the drug interact with Combee-L Tablet 21's:
Coadministration of Acitretin with Combee-L Tablet 21's can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Combee-L Tablet 21's together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use acitretin if you are pregnant. Do not stop using any medications without talking to a doctor.
EthinylestradiolTranexamic acid
Critical
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Combee-L Tablet 21's with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
LevonorgestrelBexarotene
Severe
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's and Bexarotene may decrease the effectiveness of Combee-L Tablet 21's.

How to manage the interaction:
Although taking Combee-L Tablet 21's and bexarotene can lead to interaction, it can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as increased hot flashes, vaginal dryness, or menstrual irregularities. Do not stop using any medications without talking to a doctor.
LevonorgestrelMycophenolate Mofetil
Severe
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's with Mycophenolate mofetil can decrease the levels of Combee-L Tablet 21's in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking Mycophenolate Mofetil and Combee-L Tablet 21's together can cause an interaction, it can be taken if a doctor has suggested it. Contact a doctor if you experience worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. Do not discontinue any medication without consulting a doctor.
LevonorgestrelOxcarbazepine
Severe
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's and Oxcarbazepine may lower Combee-L Tablet 21's blood levels and effects.

How to manage the interaction:
Although taking Combee-L Tablet 21's and oxcarbazepine together can result in an interaction, it can be taken if a doctor has prescribed it. If you use hormone replacement treatment (Combee-L Tablet 21's) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
LevonorgestrelRifapentine
Severe
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's and Rifapentine may lower Combee-L Tablet 21's blood levels and effects.

How to manage the interaction:
Although taking Combee-L Tablet 21's and rifapentine together can result in an interaction, they can be taken if a doctor has prescribed it. If you use hormone replacement treatment(Combee-L Tablet 21's) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
LevonorgestrelBosentan
Severe
How does the drug interact with Combee-L Tablet 21's:
Taking Combee-L Tablet 21's and Bosentan may lower the blood levels and effects of Combee-L Tablet 21's, making it less effective.

How to manage the interaction:
Although taking Combee-L Tablet 21's and bosentan can lead to interaction, it can be taken if prescribed by a doctor. However, if you experience hot flashes, vaginal dryness, or abdominal bleeding, contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
LevonorgestrelAmprenavir
Severe
How does the drug interact with Combee-L Tablet 21's:
Using amprenavir together with Combee-L Tablet 21's may cause amprenavir to be less effective.

How to manage the interaction:
Taking Combee-L Tablet 21's with Amprenavir together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away. They can help you with different choices for birth control that may suit you. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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LEVONORGESTREL-0.15MG+ETHINYLOESTRADIOL-0.03MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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LEVONORGESTREL-0.15MG+ETHINYLOESTRADIOL-0.03MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

Diet & Lifestyle Advise

  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Do regular low-strain exercise to maintain a healthy weight.
  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

Habit Forming

No

Therapeutic Class

CONTRACEPTIVES

Combee-L Tablet Substitute

Substitutes safety advice
  • Unwanted-21 Days Tablet 21's

    2.83per tablet
  • Tricycle Tablet 84's

    2.85per tablet
  • Valuecoc-L Tablet 21's

    3.11per tablet
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Combee-L Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Caution should be exercised. Hormonal medicines can affect the developing baby. It is advisable to consult a doctor before using Combee-L Tablet if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Combee-L Tablet may pass into breast milk. It may harm the baby and also may affect the production of milk. So, it is unsafe for breastfeeding mothers.

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Driving

Caution

Combee-L Tablet has no or negligible influence on the ability to drive or use machines.

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Liver

Caution

Combee-L Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor. Avoid taking Combee-L Tablet if you have severe liver disease.

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Kidney

Caution

Combee-L Tablet should be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor. Please consult your doctor.

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Children

Unsafe

Combee-L Tablet is not recommended for children. Safety and efficacy of Combee-L Tablet are established in women of reproductive age. However, sufficient studies have not been performed on women less than 16 years of age. So, take Combee-L Tablet only when prescribed by a doctor.

FAQs

Combee-L Tablet belongs to a group of medications called 'hormonal contraceptives' primarily used for contraception and in treating dysmenorrhea (irregular and painful periods).
Yes, Combee-L Tablet can cause spotting between regular periods, especially in the first few months of taking Combee-L Tablet . It usually stops once the body has adjusted to the medicine. If it continues, restarts again or becomes heavy, please inform your doctor, as it may require medical attention.
Yes, Combee-L Tablet is known to cause weight gain. Do regular exercise and eat home-cooked food to prevent weight gain.
No, Combee-L Tablet does not protect against sexually transmitted diseases (STDs). It is an oral form of contraception that does not protect against STDs. So, use some other form of contraception like condoms to avoid transmission of STDs.
You will usually get your period within three days after taking the last pill. Contact your doctor if you have any concerns.
Do not take Combee-L Tablet if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), confirmed or suspected ectopic pregnancy, asthma, blood clot problems, bleeding disorders or severe liver disease.
If you forget to take one tablet of Combee-L Tablet , take it as soon as you remember, even if it means taking two tablets simultaneously and then following the usual dosing schedule. However, if you forget to take two or more doses, you may not be completely protected against pregnancy. In this case, start taking Combee-L Tablet as soon as you remember and use a non-hormonal method such as condoms for at least the next seven days to prevent pregnancy. Frequent missing doses may cause spotting (bloodstain) or unexpected vaginal bleeding. If this persists, contact your doctor.
Combee-L Tablet is contraindicated in women with a history of breast and cervical cancer. Women with known or suspected breast carcinoma or personal history of breast cancer should not use Combee-L Tablet because breast cancer is usually a hormonally-sensitive tumour and Combee-L Tablet slightly increases your risk of breast cancer. Therefore, inform your doctor if you have had a history of breast cancer before taking Combee-L Tablet .
Combee-L Tablet is the combination oral contraceptive pill that prevents pregnancy by stopping therelease of an egg (ovulation) and altering sperm movement within the womb, making itdifficult for sperm to meet the egg. It also changes the womb's lining, making it less suitable for implantation.
Combee-L Tablet can be taken with or without food. Swallow it as a whole with water; do not crush or chew it. The doctor will determine the dose based on your condition.
Do not take Combee-L Tablet if you are allergic to any of its components, are pregnant or if you just had a baby. Avoid taking Combee-L Tablet if you have uncontrolled hypertension, coronary artery disease, heart disease, circulation issues (particularly with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, are taking certain hepatitis C medications, undergoing major surgery, smoking, over 35, or have experienced a stroke, heart attack, blood clot, jaundice from pregnancy or birth control pills, or breast, uterine/cervix, or vaginal cancer.
No, you should not take Combee-L Tablet if you smoke and are over 35 years. Avoid smoking while taking Combee-L Tablet as it might increase the risk of stroke, blood clots, or heart attack.
Combee-L Tablet may cause missed or irregular periods. If you miss your regular periods while taking Combee-L Tablet consult the doctor as you might be pregnant.
If you vomit within 3-4 hours of taking Combee-L Tablet , take another dose of Combee-L Tablet as soon as you feel better. Consult the doctor if you continue to experience vomiting or discomfort after taking Combee-L Tablet .
The common side effects of Combee-L Tablet include nausea, vomiting, breast tenderness, acne, darkening of the facial skin, and weight gain. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

636/5, Laxmi Industrial Estate, Ranchhodpura Road, Near Bhadaj, Rakanpur, Taluka: Kalol, District Gandhinagar - 382721, Gujarat, India.
Other Info - COM0666

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