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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:20 PM IST
Colinex 3MIU Powder for Injection is used to treat bacterial infections. It contains Colistimethate Sodium.  It effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, it destroys the bacteria and successfully treats the infection. Common side effects of Colinex 3MIU Powder for Injection may include injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness.
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Prescription drug

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Synonym

COLISTIN

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Colinex 3MIU Powder for Injection

Colinex 3MIU Powder for Injection belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Colinex 3MIU Powder for Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Colinex 3MIU Powder for Injection destroys the bacteria and successfully treats the infection.

Colinex 3MIU Powder for Injection will be administered by a qualified healthcare professional. Sometimes, you may experience common side effects like injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Colinex 3MIU Powder for Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Colinex 3MIU Powder for Injection can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Colinex 3MIU Powder for Injection

Treatment of Bacterial infections

Medicinal Benefits

Colinex 3MIU Powder for Injection contains Colistimethate Sodium. Colistimethate Sodium, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Colinex 3MIU Powder for Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

Directions for Use

Colinex 3MIU Powder for Injection will be administered by a qualified healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Colinex 3MIU Powder for Injection

  • Superinfection (reinfection)
  • Renal damage
  • Visual disturbances
  • GI disturbances
  • Dizziness
  • Nausea
  • Vomiting
  • Confusion
  • Peripheral neuropathy
  • Respiratory insufficiency
  • Muscle weakness

Drug Warnings

If you are allergic to Colinex 3MIU Powder for Injection, please inform your physician. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Colinex 3MIU Powder for Injection. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug Interactions

Drug-Drug Interactions: Colinex 3MIU Powder for Injection is known to interact with selective skeletal muscle relaxants (e.g. cyclobenzaprine, metaxalone), antifungals (e.g. amphotericin B) and aminoglycosides (e.g. capreomycin, vancomycin)

Drug-Food Interactions: Colinex 3MIU Powder for Injection is known to interact with alcohol and Grapefruit.

Drug-Disease Interactions: Colinex 3MIU Powder for Injection is known to interact with disease conditions, including kidney problems, myasthenia gravis (a muscle disorder), and porphyria (a blood disorder).

Drug-Drug Interactions Checker List

  • CYCLOBENZAPRINE
  • METAXALONE
  • AMPHOTERICIN B
  • CAPREOMYCIN
  • VANCOMYCIN

Habit Forming

No

Diet & Lifestyle Advise

  • After taking the full course of Colinex 3MIU Powder for Injection, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Colinex 3MIU Powder for Injection.
  • Avoid intake of alcoholic beverages with Colinex 3MIU Powder for Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Colinex 3MIU Powder for Injection in fighting off infections.

Special Advise

  • Regular blood tests are required to monitor kidney functions while taking Colinex 3MIU Powder for Injection.
  • A Healthcare professional should always give a Colinex 3MIU Powder for Injection to a hospital. Never self-administer.

Disease/Condition Glossary

Bacterial infections: A bacterial infection occurs when harmful bacteria enter the body, multiply, and infect it. It may attack any region of the body and multiply swiftly. Fever, chills, and tiredness are common symptoms. Bacteria come in a variety of shapes, including spherical, rod, and spiral-shaped bacteria. Bacterial infections range in severity from simple ailments such as sore throats and ear infections to serious brain infections such as meningitis and encephalitis. A bacterial infection can infect anyone at any time. People with a weakened immune system or who are on immunosuppressive medications, on the other hand, are more vulnerable to bacterial infection.

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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Colinex 3MIU Powder for Injection should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Colinex 3MIU Powder for Injection.

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Breast Feeding

Caution

Colinex 3MIU Powder for Injection should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Colinex 3MIU Powder for Injection.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Colinex 3MIU Powder for Injection that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Colinex 3MIU Powder for Injection if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Colinex 3MIU Powder for Injection in patients with severe kidney disease. Inform your doctor before receiving Colinex 3MIU Powder for Injection if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

Country of origin

India
Other Info - CO54131

Author Details

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FAQs

Colinex 3MIU Powder for Injection is used to treat Bacterial infections.
Colinex 3MIU Powder for Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Colinex 3MIU Powder for Injection destroys the bacteria and successfully treats the infection.
Colinex 3MIU Powder for Injection is contraindicated in people with Hypersensitivity to any component in Colinex 3MIU Powder for Injection. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).
Colinex 3MIU Powder for Injection contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Colinex 3MIU Powder for Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.
Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.
After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.
Before taking Colinex 3MIU Powder for Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Colinex 3MIU Powder for Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Colinex 3MIU Powder for Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Colinex 3MIU Powder for Injection if you are pregnant.
Colinex 3MIU Powder for Injection is safe when used as per the dose and duration advised by a doctor.
Colinex 3MIU Powder for Injection is effective when taken as per the doses prescribed by your doctor. Colinex 3MIU Powder for Injection should be administered under medical supervision for optimal results.
If you forget to take a dose of Colinex 3MIU Powder for Injection consult your healthcare provider for advice. Your doctor will guide you on the appropriate steps, but do not administer an extra dose to make up for the missed one.
Colinex 3MIU Powder for Injection causes side effects such as visual disturbances, dizziness, nausea, vomiting, confusion, muscle weakness, respiratory insufficiency, and kidney damage. Therefore, please contact a doctor if any of these side effects persist for longer durations.

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