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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Cofryl Syrup is used to provide relief from cough. Additionally, it may also help in providing relief from allergies and nasal congestion due to colds. It works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. It helps remove phlegm/mucus from the airways by decreasing its stickiness. Also, it helps reduce congestion, making it easier to cough out phlegm. Thus, it provides relief from cough. Sometimes, you may experience certain common side effects such as headache, stomach upset, dizziness, tiredness, and dry mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Cofryl Syrup

Cofryl Syrup is used to provide relief from cough. Additionally, Cofryl Syrup may also help in providing relief from allergies and nasal congestion due to colds. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from airways, thereby preventing respiratory infection.
 
Cofryl Syrup combines three drugs: Diphenhydramine, Ammonium chloride, and Sodium citrate. Diphenhydramine works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Ammonium chloride helps remove phlegm/mucus from the airways by decreasing its stickiness. Sodium citrate helps reduce congestion, making it easier to cough out through the mouth. Together, Cofryl Syrup provides relief from cough.
 
Take Cofryl Syrup as prescribed. Depending on your medical condition, you are advised to take Cofryl Syrup for as long as your doctor has prescribed it for you. Sometimes, you may experience certain common side effects such as headache, stomach upset, dizziness, tiredness, and dry mouth. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Cofryl Syrup if you are pregnant or breastfeeding. Cofryl Syrup may cause dizziness, so drive only if you are alert. Cofryl Syrup should be given to children only if prescribed by the doctor. Avoid consuming alcohol with Cofryl Syrup as it could lead to increased dizziness. Inform your doctor about all the prescription, non-prescription and herbal medicines you take to rule out any side effects/interactions.

Uses of Cofryl Syrup

Treatment of Cough, Allergies.

Directions for Use

Cofryl Syrup should be swallowed as a whole with water, do not chew, break or crush the tablet.

Medicinal Benefits

Cofryl Syrup is a combination of three drugs: Diphenhydramine, Ammonium chloride and Sodium citrate. Cofryl Syrup is used to relieve a cough accompanied by cold symptoms such as sore throat, runny nose, watery eyes, and sneezing. Additionally, Cofryl Syrup helps in providing relief from allergies. Diphenhydramine is an antihistamine that works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Ammonium chloride is an expectorant that helps remove phlegm/mucus from the airways by decreasing its stickiness. Sodium citrate is a mucolytic agent that helps loosen the congestion, making it easier to cough out through the mouth. Together, Cofryl Syrup provides relief from cough.

How Cofryl Syrup Works

Cofryl Syrup combines three drugs: Diphenhydramine, Ammonium chloride, and Sodium citrate. Diphenhydramine works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Ammonium chloride helps remove phlegm/mucus from the airways by decreasing its stickiness. Sodium citrate helps reduce congestion, making it easier to cough out through the mouth. Together, Cofryl Syrup provides relief from cough.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cofryl Syrup

  • Stomach upset
  • Dizziness
  • Sleepiness
  • Dry mouth
  • Headache

What if I have taken an overdose of Cofryl Syrup

Do not take more than the prescribed dose of Cofryl Syrup as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Cofryl Syrup if you are allergic to any of its contents. Inform your doctor before taking Cofryl Syrup if you have asthma, prostate problems, narrow-angle glaucoma, stomach or bowel ulcers, glucose-galactose malabsorption, sucrase-isomaltase deficiency, fructose intolerance, kidney or liver problems; if you are taking antidepressants or anti-Parkinson drugs or have taken them in the last 14days. Consult your doctor before taking Cofryl Syrup if you are pregnant, planning for pregnancy or breastfeeding. Cofryl Syrup may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Cofryl Syrup as it could lead to increased dizziness.

Drug-Drug Interactions

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DiphenhydramineThioridazine
Critical
DiphenhydraminePotassium citrate
Critical

Drug-Drug Interactions

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DiphenhydramineThioridazine
Critical
How does the drug interact with Cofryl Syrup 60 ml:
When Thioridazine is taken with Cofryl Syrup 60 ml, it can slow down the way Cofryl Syrup 60 ml is broken down in the body.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Thioridazine is not recommended, please consult your doctor before taking it. It can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
DiphenhydraminePotassium citrate
Critical
How does the drug interact with Cofryl Syrup 60 ml:
Taking Cofryl Syrup 60 ml and Potassium citrate together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DiphenhydramineEliglustat
Critical
How does the drug interact with Cofryl Syrup 60 ml:
When Cofryl Syrup 60 ml is taken with Eliglustat, it can cause a decrease in metabolism.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Eliglustat is not recommended, please consult your doctor before taking it. It can be taken if prescribed by your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineSodium oxybate
Critical
How does the drug interact with Cofryl Syrup 60 ml:
Taking Cofryl Syrup 60 ml with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Sodium oxybate is not recommended, but it can be taken if prescribed by a doctor. However contact your doctor if you experience shortness of breath, increased sweating, palpitations, or confusion. Do not stop using any medications without consulting a doctor.
DiphenhydraminePotassium chloride
Critical
How does the drug interact with Cofryl Syrup 60 ml:
Taking Cofryl Syrup 60 ml with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, contact your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineZonisamide
Severe
How does the drug interact with Cofryl Syrup 60 ml:
Coadministration of Zonisamide with Cofryl Syrup 60 ml can induce elevated body temperature and decreased sweating.

How to manage the interaction:
Although taking Cofryl Syrup 60 ml with Zonisamide can result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact a doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineKetamine
Severe
How does the drug interact with Cofryl Syrup 60 ml:
Taking ketamine with Cofryl Syrup 60 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Cofryl Syrup 60 ml with Ketamine can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience severe dizziness, confusion, drowsiness, confusion, difficulty concentrating, or excessive sleepiness consult your doctor immediately. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineBrexpiprazole
Severe
How does the drug interact with Cofryl Syrup 60 ml:
Cofryl Syrup 60 ml increases the blood levels of Brexpiprazole. This increases the risk of Side effects.

How to manage the interaction:
Taking Cofryl Syrup 60 ml with Brexpiprazole together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - feeling tired, unusual muscle movements, muscle spasms, shaking or jerking in your arms and legs, feeling dizzy or lightheaded, or fainting - contact your doctor right away. Do not stop using any medications without talking to a doctor.
DiphenhydramineTamoxifen
Severe
How does the drug interact with Cofryl Syrup 60 ml:
Cofryl Syrup 60 ml reduces the blood levels and effectiveness of tamoxifen.

How to manage the interaction:
Although taking Cofryl Syrup 60 ml with Tamoxifen can possibly reduce the effectiveness of Tamoxifen, they can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
DiphenhydramineTopiramate
Severe
How does the drug interact with Cofryl Syrup 60 ml:
Topiramate can induce elevated body temperature and decreased sweating, which can be exacerbated when combined with drugs that have similar effects, such as Cofryl Syrup 60 ml.

How to manage the interaction:
Although taking Cofryl Syrup 60 ml with Topiramate can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact your doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Gargle with salt water for relief from sore throat.

  • Avoid smoking and consumption of alcohol.

  • Avoid dairy products such as milk, as it may increase mucus production. Also, avoid processed or refined foods. Replace baked foods, fried foods, white bread, white pasta, french fries, sugary desserts and chips with green leafy vegetables.

  • Drink plenty of fluids to avoid a dry throat while you have a cough. It also helps loosen mucus.

  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

ANTIHISTAMINE AND ANTITUSSIVE ANTIHISTAMINES

Cofryl Syrup Substitute

Substitutes safety advice
  • Cofsils Cough Syrup 100 ml

    by COFSILS

    0.99per tablet
  • Cofsils Sugar Free Cough Syrup 100 ml

    0.89per tablet
  • Mahadryl Syrup 100 ml

    0.84per tablet
  • StayHappi Diphenhydramine+Ammonium Chloride+Sodium Citrate 14.08mg/138mg/57.03mg Syrup

    0.32per tablet
  • Suntuss CF Sugar Free Menthol-Raspberry Flavour Cough Formula 100 ml

    0.74per tablet
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Alcohol

Caution

Cofryl Syrup is taken along with Cofryl Syrup may cause excessive drowsiness and sleepiness.

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Pregnancy

Caution

Cofryl Syrup should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Cofryl Syrup.

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Breast Feeding

Caution

Cofryl Syrup should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Cofryl Syrup.

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Driving

Caution

Cofryl Syrup is known to cause drowsiness and dizziness, so driving a car or operating any machinery which requires concentration should not be done.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Cofryl Syrup should be given to children only if prescribed by the doctor.

FAQs

Cofryl Syrup belongs to a group of medicines called expectorants and cough products used to relieve cough. Also, Cofryl Syrup may help reduce allergies and nasal congestion due to colds.
Cofryl Syrup is a combination drug containing three medicines: Diphenhydramine, Ammonium Chloride and Sodium Citrate. Diphenhydramine blocks a natural substance (histamine) during an allergic reaction. Ammonium chloride decreases mucus stickiness, and sodium citrate being mucolytic, loosens the mucus and makes it easier to cough out. Together it helps relieve allergy symptoms like sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness.
You should not take Cofryl Syrup if you have asthma, as it might worsen your condition and lead to breathing problems.
Do not take Cofryl Syrup if you have breathing problems like asthma, chronic bronchitis, vision problems like glaucoma or difficulty in peeing due to an enlarged prostate gland. Besides this, if you are taking alcohol, peptic ulcer, sleeping pills, or antianxiety pills, immediately stop taking Cofryl Syrup as it might induce drowsiness and dizziness.
Cofryl Syrup is known to cause drowsiness and sleepiness, so it is recommended not to drive a car or operate any machinery which requires concentration. Also, do not consume alcohol as it might increase drowsiness.
The most common side effects of Cofryl Syrup are sleepiness, impaired coordination, stomach pain, dizziness, and thickened respiratory tract secretions. These side effects usually go away during the treatment.
Dry mouth could be a side-effect of Cofryl Syrup. Limiting caffeine intake, avoiding smoking, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - COF0014

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