COFDEX P LIQUID belongs to the class of medications called ‘Expectorant and Cough products’ used in the treatment of dry cough associated with cold/flu, allergies, and throat irritants. A cough is a reflex action that helps to clear any foreign irritant or mucus in the throat. Dry cough refers to a cough with no mucus (sputum) or secretions. A dry cough is mostly treated with cough suppressants and throat lozenges.

COFDEX P LIQUID contains Bromhexine, Dextromethorphan, and Phenylpropanolamine. Bromhexine is an expectorant/mucolytic agent which thins mucus (phlegm) making it cough out easily.  Dextromethorphan is a cough suppressant and acts by blocking the action of the cough centre in the brain that is responsible for the cough reflex. Phenylpropanolamine is a decongestant that narrows the small blood vessels providing relief from congestion or stuffiness in the nose.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of COFDEX P LIQUID are dizziness, headache, confusion, slow or shallow breathing, restlessness, nausea, vomiting, tremors, diarrhoea, stomach pain, skin rash, itching, palpitations (pounding heartbeat), and insomnia (difficulty to sleep). These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take COFDEX P LIQUID if you are allergic to any contents of it. Do not use COFDEX P LIQUID if you have taken monoamine oxidase (MAO) inhibitors, a type of antidepressant in the past 14 days. Before taking COFDEX P LIQUID, inform your doctor if you have liver or kidney disease, high blood pressure, heart disease, thyroid problems, glaucoma (increased pressure in the eye), and an enlarged prostate gland or difficulty urinating. It is not recommended for use in children below 4 years of age. It should be used with caution in pregnant women, breastfeeding mothers, and elderly people. Alcohol may increase the risk of side-effects. COFDEX P LIQUID may cause dizziness, so do not drive, or operate heavy machinery if you are not fully alert.

COFDEX P LIQUID is used in the treatment of dry cough which is associated with cold/flu, allergies, or throat irritants. It can suppress severe cough and helps to relieve congestion. It can also provide relief from a sore throat which is often accompanied by a dry cough. Take this medicine exactly as prescribed by the doctor for the best results.

• Dizziness
• Headache
• Confusion
• Slow or shallow breathing
• Restlessness
• Nausea
• Vomiting
• Tremors
• Diarrhoea
• Stomach pain
• Skin rash
• Itching
• Palpitations (pounding heartbeat)
• Insomnia (difficulty to sleep)

It is advised not to take COFDEX P LIQUID if you have taken antidepressants (especially monoamine oxidase (MAO) inhibitors) in the past 14 days as it may cause life-threatening side-effects. COFDEX P LIQUID should be used with caution in children with a history of allergies. COFDEX P LIQUID should be used with caution in patients with peptic ulcer disease (stomach ulcers) as it may disrupt the mucous barrier in the stomach. It should also be used with caution in patients with asthma, severe liver, or kidney disease. Do not use any other cough or cold medicines while using COFDEX P LIQUID.

Drug-Drug Interactions: COFDEX P LIQUID may interact with antidepressants (isocarboxazid, tranylcypromine, selegiline, rasagiline, and methylene blue, etc.), antibiotics, non-steroidal anti-inflammatory drugs (celecoxib and indomethacin), anticancer agents (imatinib), a medicine used to treat heart rhythm problems (quinidine), a medicine used to treat chest pain (ranolazine), a medicine used to treat HIV (ritonavir), a medicine used to treat obesity (sibutramine), antifungal medicine (terbinafine), medicines used to treat high blood pressure (guanethidine and methyldopa), antibacterial agent (furazolidone), a medicine used to treat respiratory problems (theophylline), antipsychotic drugs (chlorpromazine, thioridazine, and prochlorperazine),

Drug-Food Interactions: COFDEX P LIQUID may interact with caffeine present in cola, coffee, chocolate, and other products containing caffeine.  

Drug-Disease Interactions: COFDEX P LIQUID should be used with caution in patients with liver or kidney disease, high blood pressure, heart disease, asthma, stomach ulcers, thyroid problems, glaucoma (increased pressure in the eye), and an enlarged prostate gland or difficulty urinating.

• ISOCARBOXAZID
• TRANYLCYPROMINE
• SELEGILINE
• RASAGILINE
• METHYLENE BLUE
• CELECOXIB
• INDOMETHACIN
• IMATINIB
• QUINIDINE
• RANOLAZINE
• RITONAVIR
• SIBUTRAMINE
• TERBINAFINE
• GUANETHIDINE
• METHYLDOPA
• FURAZOLIDONE
• THEOPHYLLINE
• CHLORPROMAZINE
• THIORIDAZINE
• PROCHLORPERAZINE

• Avoid smoking as it may worsen your cough. Avoid second-hand or passive smoking too.
• Drink plenty of water to decrease throat irritation.
• Use a humidifier to moisten the air.
• Gargle with salt-water and have honey as they may help to suppress the cough.
• Avoid caffeinated and cold drinks as these may worsen the cough.

Dry Cough: Cough is a reflex action that helps to clear any foreign irritant or irritants in the throat. Cough is of two types: dry cough and wet cough. In dry cough, no sputum is expelled and there is a sore throat, whereas, in wet cough, you cough-up sputum. Dry cough can be acute (short-term) or chronic (long-term). The most common causes of acute dry cough are cold/flu, allergic rhinitis (hay fever), and smoking. Acute dry cough can be treated with cough suppressants and throat lozenges. Chronic dry cough usually occurs due to asthma, gastroesophageal reflux, smoking, and lung cancer.