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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:47 PM IST
Co-Trimoxazole Double Strength Tablet is used to treat bacterial infections. It contains Trimethoprim and Sulfamethoxazole which work by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as headache, diarrhoea, skin rashes, nausea, vomiting, and mouth ulcers. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer

Cadila Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Co-Trimoxazole Double Strength Tablet

Co-Trimoxazole Double Strength Tablet is used to treat and prevent lung infections caused by a bacteria called Pneumocystis jirovecii, infections caused by a bacteria called Toxoplasma, urinary tract infections (water infections), respiratory tract infections such as bronchitis, ear infections such as otitis media. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Co-Trimoxazole Double Strength Tablet does not work against infections caused by the virus, including cold and flu.

Co-Trimoxazole Double Strength Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, Co-Trimoxazole Double Strength Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections.

Take Co-Trimoxazole Double Strength Tablet as prescribed by your doctor. The dose and duration of Co-Trimoxazole Double Strength Tablet can vary depending on your condition and the severity of the infection. In some cases, you may experience certain common side effects such as headache, diarrhoea, skin rashes, nausea, vomiting, heart problems, fever, convulsions or seizures, blood or cloudiness in your urine, hallucinations, and mouth ulcers. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Co-Trimoxazole Double Strength Tablet , please inform your doctor if you have any allergy (against any antibiotic) or kidney or liver problems. Do not take Co-Trimoxazole Double Strength Tablet on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Co-Trimoxazole Double Strength Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Co-Trimoxazole Double Strength Tablet should not be given to children below 12 years. Keep your doctor informed about all the medicines you are taking and your health condition to rule out any unpleasant side effects. Also, it is recommended to complete the course of medicine even if you feel better, as it is an antibiotic. Leaving it in between may lead to even severe infection that will, in fact, stop responding to the antibiotic (antibiotic resistance).

Uses of Co-Trimoxazole Double Strength Tablet

Treatment of Bacterial infections

Medicinal Benefits

Co-Trimoxazole Double Strength Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain, and toxoplasmosis (infection caused by a bacteria called toxoplasma). Co-Trimoxazole Double Strength Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, Co-Trimoxazole Double Strength Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Co-Trimoxazole Double Strength Tablet is a broad-spectrum antibiotic that is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Directions for Use

Take it as advised by your doctor. Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Co-Trimoxazole Double Strength Tablet

  • Mouth ulcers
  • Headache
  • Mouth ulcers
  • Diarrhea
  • Blood or cloudiness in your urine
  • Depression
  • Tingling or numbness in your hands and feet
  • Hallucinations

Drug Warnings

Do not take Co-Trimoxazole Double Strength Tablet if you are allergic to any of its contents if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem that affects the skin or nervous system). Do not take Co-Trimoxazole Double Strength Tablet on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pains. Talk to your doctor before taking Co-Trimoxazole Double Strength Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight, or malnourished if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Avoid taking Co-Trimoxazole Double Strength Tablet if you are pregnant or breastfeeding unless prescribed by a doctor. Avoid alcohol consumption while taking Co-Trimoxazole Double Strength Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Co-Trimoxazole Double Strength Tablet will not treat a viral infection. Drink plenty of fluids to prevent kidney stones while taking Co-Trimoxazole Double Strength Tablet .

Drug Interactions

Drug-Drug Interactions: Co-Trimoxazole Double Strength Tablet may interact with medicines used to treat the symptoms of Parkinson's disease (amantadine), drugs used to prevent organ rejection(cyclosporine), a medicine used to relieve pain, swelling (indomethacin), drugs used to decrease the toxic effects of methotrexate (leucovorin), anticancer drug (methotrexate), medicines used to treat the parasite diseases (pyrimethamine), blood pressure medication (benazepril, quinapril, enalapril, lisinopril, ramipril); a diuretic or 'water pill' (chlorthalidone, hydrochlorothiazide), a blood thinner (warfarin).

Food-Drug Interactions: Avoid alcohol consumption while taking Co-Trimoxazole Double Strength Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Disease Interactions: If you have severe liver disease, kidney disease, asthma, malnourishment, HIV or AIDS, or thyroid disorders, inform your doctor before taking Co-Trimoxazole Double Strength Tablet .

Drug-Drug Interactions Checker List

  • AMANTADINE
  • CYCLOSPORINE
  • INDOMETHACIN
  • LEUCOVORIN
  • METHOTREXATE
  • PYRIMETHAMINE
  • BENAZEPRIL
  • QUINAPRIL
  • ENALAPRIL
  • LISINOPRIL
  • RAMIPRIL
  • CHLORTHALIDONE
  • HYDROCHLOROTHIAZIDE
  • WARFARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which helps in digestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk natto, and cheese.

  • Eat fiber-rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas.

  • Avoid foods rich in calcium, grapefruit, and grapefruit juice, as they might hinder antibiotic absorption.

  • Avoid the consumption of alcohol to treat your condition effectively.

  • Avoid the usage of tobacco.

  • To cure your condition, effectually complete the full course of Co-Trimoxazole Double Strength Tablet even though you find symptomatic relief.

Special Advise

  • Co-Trimoxazole Double Strength Tablet may affect certain laboratory test results, such as blood tests. Inform the person doing the tests that you are taking Co-Trimoxazole Double Strength Tablet . Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed Co-Trimoxazole Double Strength Tablet for a longer duration to know if the medicine is working properly.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Anyone can become infected with a bacterial infection. However, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.

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Alcohol

Unsafe

Avoid alcohol consumption while taking Co-Trimoxazole Double Strength Tablet to prevent unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor before taking Co-Trimoxazole Double Strength Tablet if you are pregnant. Your doctor will prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding; your doctor will prescribe this medicine only if the benefits outweigh the risks.

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Driving

Caution

It is unknown whether Co-Trimoxazole Double Strength Tablet affects your ability to drive and operate machinery. Drive only if you are physically stable and mentally focused; you may experience dizziness or fatigue after taking Co-Trimoxazole Double Strength Tablet you should not drive or operate any machinery or vehicles.

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Liver

Caution

Please consult your doctor before taking Co-Trimoxazole Double Strength Tablet if you have liver conditions. Your doctor will weigh the benefits and any potential risks before prescribing.

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Kidney

Caution

Co-Trimoxazole Double Strength Tablet to be taken with caution, especially if you have a history of kidney conditions. Your doctor may adjust the dose based on your condition.

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Children

Unsafe

Co-Trimoxazole Double Strength Tablet should not be given to children below 12 years.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - COT0181

Author Details

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FAQs

Co-Trimoxazole Double Strength Tablet is used to treat and prevent bacterial infections of the lung, urinary tract, respiratory tract (bronchitis), and ear (otitis media).
Co-Trimoxazole Double Strength Tablet contains Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of bacteria. By inhibiting these, Co-Trimoxazole Double Strength Tablet kills the bacteria and stops their growth. Thus, helps to treat bacterial infections.
Co-Trimoxazole Double Strength Tablet causes thrush or candidiasis, a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.
Diarrhoea might be a side-effect of Co-Trimoxazole Double Strength Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Co-Trimoxazole Double Strength Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.
It is recommended to complete the course of Co-Trimoxazole Double Strength Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking Co-Trimoxazole Double Strength Tablet for as long as your doctor has prescribed to treat your condition effectually.
Co-Trimoxazole Double Strength Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking Co-Trimoxazole Double Strength Tablet .
Co-Trimoxazole Double Strength Tablet may cause high levels of potassium in the blood, leading to abnormal heartbeats (palpitations). Regular potassium levels and heart rate monitoring is recommended while taking Co-Trimoxazole Double Strength Tablet .
Co-Trimoxazole Double Strength Tablet is a combination medication that contains two antibiotics: Sulfamethoxazole (a sulfonamide) and Trimethoprim (a folic acid inhibitor). It is used to treat and prevent bacterial infections.
Co-Trimoxazole Double Strength Tablet is generally safe when used in your doctor's recommended dose and duration. While it is usually well-tolerated, Co-Trimoxazole Double Strength Tablet may cause mild side effects such as headache, diarrhoea, skin rashes, nausea, vomiting, hallucinations, and mouth ulcers. These side effects usually resolve on their own over time. It is essential to use Co-Trimoxazole Double Strength Tablet with caution in patients with severe kidney or liver problems. If you have any concerns about the safety of Co-Trimoxazole Double Strength Tablet , please consult your doctor.
The use of Co-Trimoxazole Double Strength Tablet may cause nausea and vomiting as side effects in some individuals. To help prevent these symptoms, take the medication with food, stay hydrated with clear fluids, and wait 30 minutes before lying down after taking Co-Trimoxazole Double Strength Tablet . If nausea or vomiting persists, please consult your doctor.
Yes, Co-Trimoxazole Double Strength Tablet is contraindicated in patients allergic to its ingredients or those with severe liver or kidney problems, thrombocytopenia (low platelet count), or porphyria (a rare blood disorder). Co-Trimoxazole Double Strength Tablet should not be used during pregnancy, as it may cause congenital disabilities, maternal folic acid deficiency, or preterm labour. Additionally, Co-Trimoxazole Double Strength Tablet is excreted in breast milk and should not be used by breastfeeding mothers.
While taking Co-Trimoxazole Double Strength Tablet , you should avoid excessive alcohol consumption, as it may increase the risk of side effects such as fast heartbeats, warmth or redness under your skin, a tingling sensation, nausea, and vomiting. Additionally, avoid sun exposure or use sunscreen, as the medication may increase sensitivity to sunlight, making you more prone to sunburn. Do not take Co-Trimoxazole Double Strength Tablet on your own, as self-medication may lead to antibiotic resistance, where antibiotics fail to work against specific bacterial infections.
Co-Trimoxazole Double Strength Tablet should be stored at room temperature, away from direct sunlight and moisture. Keep it out of reach of children. Do not freeze it.
If you miss a dose of your medication, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose. Do not take two doses at once to make up for the missed dose.
If you don't get better after using Co-Trimoxazole Double Strength Tablet , please contact your doctor. You may need a different treatment or further evaluation. Sometimes, the infection could resist the medication, or other underlying issues may require attention. Do not stop taking Co-Trimoxazole Double Strength Tablet without consulting your doctor, even if you do not feel better immediately.
Co-Trimoxazole Double Strength Tablet may cause common side effects such as headache, diarrhoea, skin rashes, nausea, vomiting, heart problems, fever, convulsions or seizures, blood or cloudiness in your urine, hallucinations, and mouth ulcers. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, please talk to your doctor.
Take the prescribed dose of Co-Trimoxazole Double Strength Tablet as directed by your doctor. Shake the bottle well before use to ensure the medication is mixed evenly. Measure the prescribed dose using the provided measuring cap and take it with or without food.

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