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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

CLADRIM 10MG INJECTION is used to treat hairy cell leukaemia (cancer of a specific type of white blood cell). It contains Cladribine, a class of medications known as purine analogues. It works by stopping or slowing the growth of cancer cells. Common side effects of this medication include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection.

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Composition :

CLADRIBINE-10MG

Manufacturer/Marketer :

Dabur India Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

CLADRIM 10MG INJECTION may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. A trained healthcare professional will administer CLADRIM 10MG INJECTION. Hence, do not self-administer.

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of CLADRIM 10MG INJECTION

Treatment of Hairy cell Leukemia

Medicinal Benefits

CLADRIM 10MG INJECTION contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, CLADRIM 10MG INJECTION stops the multiplication of abnormal cells and causes the death of cancer cells.

Side Effects of CLADRIM 10MG INJECTION

  • Nausea
  • Abdominal pain
  • Constipation
  • Weakness
  • Injection site reactions
  • Pain at the site of injection
  • Headache
  • Dizziness
  • Insomnia
  • Anxiety
  • Muscle pain
  • Rash

Directions for Use

An oncology doctor will administer CLADRIM 10MG INJECTION. Self-administration is not recommended.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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CladribineDactinomycin
Severe
CladribineDapsone
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

How CLADRIM 10MG INJECTION Works

CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

What if I have taken an overdose of CLADRIM 10MG INJECTION

As CLADRIM 10MG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of CLADRIM 10MG INJECTION may cause black and tarry or bloody stools, bloody vomit or vomited material that looks like coffee grounds, decreased urination, fever, sore throat, chills, or other signs of infection, loss of ability to move the arms or legs, pain, burning, numbness, or tingling in the hands or feet, swelling of the face, arms, hands, feet, ankles, or lower legs, unusual tiredness or weakness, unusual bleeding or bruising and weakness in the arms or legs.
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Alcohol

Caution

It is not known if alcohol interacts with CLADRIM 10MG INJECTION. Please consult the doctor.

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Pregnancy

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving CLADRIM 10MG INJECTION. You should not become pregnant while on treatment with CLADRIM 10MG INJECTION.

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Breast Feeding

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

CLADRIM 10MG INJECTION will be administered to hospitalized patients. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

CLADRIM 10MG INJECTION is not recommended for use in children as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

8/3, Asaf Ali Road, New Delhi-110002
Other Info - CLA0132

Author Details

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FAQs

CLADRIM 10MG INJECTION is used to treat Hairy cell Leukemia.
CLADRIM 10MG INJECTION contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.
It is said that concomitant use of CLADRIM 10MG INJECTION along with live vaccines may cause serious adverse effects. Hence, inform your doctor if you have taken any vaccines recently before receiving CLADRIM 10MG INJECTION.
No, CLADRIM 10MG INJECTION is not a vesicant. CLADRIM 10MG INJECTION belongs to a group of anticancer medications called purine analogues used in the treatment of hairy cell leukaemia (a rare type of blood and bone marrow cancer).
CLADRIM 10MG INJECTION may cause hair loss in some cases. However, it is an uncommon side effect of CLADRIM 10MG INJECTION. Consult the doctor if you notice hair loss during treatment with CLADRIM 10MG INJECTION.
The common side effects of CLADRIM 10MG INJECTION may include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult the doctor.

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