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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Citafine 1Gm Inj is an anti-cancer medicine used in the treatment of breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. This medicine works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include nausea, hair loss, skin rash, vomiting, and oedema.
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Composition :

GEMCITABINE-200MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Citafine 1Gm Inj

Citafine 1Gm Inj belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body.

Citafine 1Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Citafine 1Gm Inj is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers. 

A healthcare professional will administer Citafine 1Gm Inj. Do not self-administer. Citafine 1Gm Inj may cause certain common side effects such as nausea, hair loss, skin rash, vomiting, and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of the components. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Talk to your doctor if you are planning to father a child before taking Citafine 1Gm Inj; your doctor may advise you regarding sperm storage. Avoid taking alcohol with Citafine 1Gm Inj.

Uses of Citafine 1Gm Inj

Treatment of Breast Cancer, Pancreatic Cancer, Non-small-cell Lung Cancer, Bladder Cancer, and Ovarian Cancer

Directions for Use

A healthcare professional will administer Citafine 1Gm Inj. Do not self-administer.

Medicinal Benefits

Citafine 1Gm Inj is an anti-cancer drug used in the treatment of various types of cancers. Citafine 1Gm Inj is used either independently or in conjunction with other chemotherapy medications to treat breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Citafine 1Gm Inj works by interfering with DNA synthesis. It blocks the production of new DNA, by locking itself into the DNA strands and inhibiting any further proliferation or growth of the cell. Hence, Citafine 1Gm Inj has widespread application in the field of oncology (cancer-related medicine) and chemotherapy.

How Citafine 1Gm Inj Works

Citafine 1Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Citafine 1Gm Inj is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Citafine 1Gm Inj

  • Nausea
  • Vomiting
  • Hair loss
  • Flu-like symptoms such as high temperature, chills
  • Swelling of ankles, fingers, toes, feet
  • Low blood levels (anaemia)
  • Shortness of breath

What if I have taken an overdose of Citafine 1Gm Inj

Since Citafine 1Gm Inj is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe rash, pain, burning, or tingling in the hands or feet, unusual bleeding or bruising, red/black/tarry stools, pink/red/dark brown urine, coughing up or vomiting blood or material that looks like coffee grounds, signs of infection (fever, sore throat, ongoing cough and congestion), and extreme tiredness.

Drug Warnings

Citafine 1Gm Inj should not be used in case of any known allergy to any of the components. Citafine 1Gm Inj should be used with caution in case of high risk or previous history of heart disease, vascular disease, liver problems, kidney disease or alcoholism. Keep your doctor informed if you suffer from any shortness of breath, kidney problems, hypertension diabetes or epilepsy. Avoid Citafine 1Gm Inj during pregnancy and breastfeeding. Offer a detailed medical history, vaccination history, and inform the doctor especially if you are on any radiotherapy.

Drug-Drug Interactions

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GemcitabineNatalizumab
Severe
GemcitabineAdalimumab
Severe

Drug-Drug Interactions

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GemcitabineNatalizumab
Severe
How does the drug interact with Citafine 1Gm Inj:
Combining Citafine 1Gm Inj with Natalizumab can increase the risk of side effects.

How to manage the interaction:
Co-administration of Citafine 1Gm Inj with Natalizumab can result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms such as fever, diarrhea, sore throat, muscle aches, or vision changes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineAdalimumab
Severe
How does the drug interact with Citafine 1Gm Inj:
Combining Adalimumab with Citafine 1Gm Inj can increase the risk of side effects like developing serious infections.

How to manage the interaction:
Although taking Citafine 1Gm Inj and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like feeling sick, having a fever, diarrhea, a sore throat, muscle aches, weight loss, pain when you pee, or having trouble breathing it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineTofacitinib
Severe
How does the drug interact with Citafine 1Gm Inj:
Coadministration of Tofacitinib and Citafine 1Gm Inj can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Citafine 1Gm Inj, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineGolimumab
Severe
How does the drug interact with Citafine 1Gm Inj:
Combining Citafine 1Gm Inj with Golimumab can increase the risk of infections.

How to manage the interaction:
Taking Citafine 1Gm Inj with Golimumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain/burning when you urinate. Do not stop using any medications without a doctor's advice.
GemcitabineLeflunomide
Severe
How does the drug interact with Citafine 1Gm Inj:
Combining Citafine 1Gm Inj with Leflunomide can increase the risk or severity of developing serious infection

How to manage the interaction:
There may be a possibility of interaction between Leflunomide and Citafine 1Gm Inj, but it can be taken if prescribed by a doctor. If you notice any of these signs - like feeling sick, having a fever or chills, diarrhea, a sore throat, muscle pain, trouble breathing, weight loss, pain or burning urination, joint pain, swelling or bruising, a rash or itching, loss of appetite, feeling tired, or having nausea, vomiting, dark urine, or bleeding. Do not discontinue any medications without consulting a doctor.
GemcitabineTeriflunomide
Severe
How does the drug interact with Citafine 1Gm Inj:
Combining Citafine 1Gm Inj with Teriflunomide can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Citafine 1Gm Inj and Teriflunomide, but it can be taken if prescribed by a doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain or burning when urinating, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineMipomersen
Severe
How does the drug interact with Citafine 1Gm Inj:
Coadministration of Citafine 1Gm Inj with Mipomersen can lead to or increase the risk of liver injury.

How to manage the interaction:
Taking Citafine 1Gm Inj with Mipomersen together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GemcitabineDeferiprone
Severe
How does the drug interact with Citafine 1Gm Inj:
Citafine 1Gm Inj can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Citafine 1Gm Inj and Deferiprone, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating contact a doctor right away. Do not stop using any medications without a doctor's advice.
GemcitabineEtanercept
Severe
How does the drug interact with Citafine 1Gm Inj:
Taking Etanercept with Citafine 1Gm Inj can increase the risk of infections.

How to manage the interaction:
Taking Etanercept with Citafine 1Gm Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineVoclosporin
Severe
How does the drug interact with Citafine 1Gm Inj:
When Citafine 1Gm Inj is taken with Voclosporin, the amount of Citafine 1Gm Inj in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Citafine 1Gm Inj and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.
  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Avoid taking Citafine 1Gm Inj with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Citafine 1Gm Inj Substitute

Substitutes safety advice
  • CYTOGEM 200MG INJECTION

    1310.00per tablet
  • CELGEM 200MG INJECTION.

    1176.30per tablet
  • Gemcite 200 mg Injection

    1280.40per tablet
  • GEMCHEM 200MG INJECTION

    523.40per tablet
  • Celzar 200Mg Inj

    by AYUR

    1309.95per tablet
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Alcohol

Unsafe

It is not recommended to use alcohol with Citafine 1Gm Inj as it might lead to increased drowsiness.

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Pregnancy

Unsafe

Citafine 1Gm Inj should be avoided during pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Citafine 1Gm Inj is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Citafine 1Gm Inj may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using Citafine 1Gm Inj.

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Liver

Caution

Exercise caution before using Citafine 1Gm Inj in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Citafine 1Gm Inj in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Citafine 1Gm Inj is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

FAQs

Citafine 1Gm Inj belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.
Citafine 1Gm Inj works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.
Men taking Citafine 1Gm Inj are advised not to father a child during the treatment with Citafine 1Gm Inj and for 6months after the treatment. Consult your doctor before starting Citafine 1Gm Inj if you are planning to father a child. Your doctor may advise you regarding sperm storage.
If you suffer from CKD, please consult with your doctor before using Citafine 1Gm Inj and discuss any concerns with them. Citafine 1Gm Inj is to be used with caution in those suffering from kidney and liver problems.
Citafine 1Gm Inj might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.
Citafine 1Gm Inj may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.
Citafine 1Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.
The side effects of Citafine 1Gm Inj include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - CIT0070

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