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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 6:04 AM IST

Citac 0.5 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Composition

TACROLIMUS-0.5MG

Manufacturer/Marketer

Advaith Life Sciences Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Citac 0.5 Capsule

Citac 0.5 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Citac 0.5 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Citac 0.5 Capsule as prescribed. You are advised to use Citac 0.5 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Citac 0.5 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Citac 0.5 Capsule . Avoid alcohol consumption with Citac 0.5 Capsule . Drive only if you are alert, as Citac 0.5 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Citac 0.5 Capsule . Citac 0.5 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Citac 0.5 Capsule

Citac 0.5 Capsule is used for prevention of transplanted organ rejection

Medicinal Benefits

Citac 0.5 Capsule contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Citac 0.5 Capsule suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Citac 0.5 Capsule

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Citac 0.5 Capsule . Avoid alcohol consumption with Citac 0.5 Capsule . Drive only if you are alert, as Citac 0.5 Capsule may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Citac 0.5 Capsule . Citac 0.5 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Citac 0.5 Capsule , you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug Interactions

Drug-Drug Interaction: Inform your doctor if you are taking immunosuppressant (cyclosporine, sirolimus), anti-HIV drugs (nelfinavir), anticonvulsants (phenytoin), antifungals (itraconazole, ketoconazole, voriconazole), antibiotics (erythromycin, clarithromycin), diuretics (triamterene, amiloride) and other medicines. 

Drug-Food Interaction: Citac 0.5 Capsule may interact with St. John’s Wort (a herbal supplement to treat depression). Avoid taking grapefruit and grapefruit juice with Citac 0.5 Capsule as it may cause serious side effects. Also, avoid consumption of alcohol with Citac 0.5 Capsule .

Drug-Disease Interaction: If you have liver, kidney or heart problems, inform your doctor before taking Citac 0.5 Capsule .

Drug-Drug Interactions Checker List

  • CYCLOSPORINE
  • SIROLIMUS
  • NELFINAVIR
  • PHENYTOIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TRIAMTERENE
  • AMILORIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Special Advise

Regular blood tests and certain other tests are recommended while taking Citac 0.5 Capsule to check blood sugar levels, kidney functioning and potassium levels in the blood.

Disease/Condition Glossary

Organ rejection: It occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it. Organ rejection may be hyperacute (occurs in minutes to hours), acute (occurs within the first few months), or chronic (occurs after a year or time beyond). The symptoms of organ rejection may vary based on the type of organ transplant you have had. However, if you experience pain, fever, or other signs of illness, contact your doctor immediately.

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Alcohol

Unsafe

Avoid alcohol consumption with Citac 0.5 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Citac 0.5 Capsule .

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Citac 0.5 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Citac 0.5 Capsule .

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Breast Feeding

Consult your doctor

Citac 0.5 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Citac 0.5 Capsule . You should avoid taking Citac 0.5 Capsule during breastfeeding or avoid breastfeeding while on treatment with Citac 0.5 Capsule .

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Driving

Caution

Citac 0.5 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Citac 0.5 Capsule .

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Citac 0.5 Capsule .

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Citac 0.5 Capsule .

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Children

Safe if prescribed

Citac 0.5 Capsule should be used in children in doses as advised by a doctor only.

Country of origin

India

Manufacturer/Marketer address

A-89, 3rd floor, DDA Shed, Okhla Industrial Phase-2, New Delhi – 110020
Other Info - CIT0360

Author Details

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FAQs

Citac 0.5 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart.
Citac 0.5 Capsule contains Tacrolimus, an immunosuppressant that works by the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.
Citac 0.5 Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.
Citac 0.5 Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for a long time or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Citac 0.5 Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.
Using Citac 0.5 Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Citac 0.5 Capsule with other medications.
Citac 0.5 Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.
Citac 0.5 Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.
Citac 0.5 Capsule is a macrolide antibiotic with immunosuppressant properties.
Citac 0.5 Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.
Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.
Citac 0.5 Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).
No, Citac 0.5 Capsule does not have an abuse potential as it is not a controlled substance.
Side effects of Citac 0.5 Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

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