Cintarab-SR Capsule belongs to a class of drugs called gastrointestinal agents used to treat gastroesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. Zollinger-Ellison syndrome is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production.

Cintarab-SR Capsule is a combination of two drugs: Rabeprazole (proton pump inhibitor) and Cinitapride (gastroprokinetic agent). Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. On the other hand, Cinitapride increases the food pipe movement (oesophagus), small intestine and stomach, thereby enhancing bowel movement and the digestive tract gets emptied from the food in a shorter time. Together, Cintarab-SR Capsule helps in preventing acid reflux, thereby provides relief from hyperacidity and heartburn.

Take Cintarab-SR Capsule as prescribed by your doctor. You are advised to take Cintarab-SR Capsule for as long as your doctor has prescribed it for you based on your medical condition. You may experience diarrhoea, nausea, vomiting, headache, dizziness, flatulence (gas), stomach pain, or constipation in some cases. Most of these side effects of Cintarab-SR Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Cintarab-SR Capsule or any other medicines, please tell your doctor. Cintarab-SR Capsule is not recommended for children as safety and effectiveness were not established. Avoid taking Cintarab-SR Capsule if you are pregnant, especially in the first 3 months of pregnancy as it may cause harm to the fetus. Therefore, if you are pregnant or breastfeeding, please inform your doctor before taking Cintarab-SR Capsule . Inform your doctor if you have any risk factors for reduced vitamin B12 as Cintarab-SR Capsule may reduce the absorption of vitamin B12. Drive only if you are alert as Cintarab-SR Capsule may cause drowsiness. Avoid alcohol consumption as it may lead to increased stomach acid production, thereby increasing acidity and heartburn.

Cintarab-SR Capsule is a combination of two drugs, namely: Rabeprazole and Cinitapride used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole blocks the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. On the other hand, Cinitapride increases the food pipe movement (esophagus), small intestine, and stomach, thereby enhancing bowel movement and the digestive tract gets emptied from the food in a shorter time. Together, Cintarab-SR Capsule helps in preventing acid reflux, thereby providing relief from hyperacidity and heartburn.

• Diarrhoea
• Nausea
• Vomiting
• Headache
• Dizziness
• Flatulence (gas)
• Stomach pain
• Constipation

If you are allergic to Cintarab-SR Capsule or any other medicines, please tell your doctor. Cintarab-SR Capsule is not recommended for children as safety and effectiveness were not established. Avoid taking Cintarab-SR Capsule if you are pregnant, especially in the first 3 months of pregnancy as it may cause harm to the fetus. Therefore, if you are pregnant or breastfeeding, please inform your doctor before taking Cintarab-SR Capsule . If you have a stomach tumor, liver problems, bleeding, low magnesium levels in the blood, osteoporosis (weak and brittle bones), or lupus (an autoimmune disorder), inform your doctor before taking Cintarab-SR Capsule . Inform your doctor if you have any risk factors for reduced vitamin B12 as Cintarab-SR Capsule may reduce the absorption of vitamin B12. If you get any skin rash, particularly in areas exposed to sun, or have pain in joints, inform your doctor. If you are taking Cintarab-SR Capsule for more than 1 year, it may increase the risk of fracture of the spine, hip, or wrist. Drive only if you are alert as Cintarab-SR Capsule may cause drowsiness. Avoid alcohol consumption as it may lead to increased stomach acid production, thereby increasing acidity and heartburn. Cintarab-SR Capsule may decrease magnesium levels in the blood, especially if taken for more than 3 months. Therefore, regular blood tests are recommended to monitor magnesium levels. If you experience bloody or watery diarrhoea with symptoms such as stomach pain, fever, or tenderness, contact your doctor immediately.

Drug-Drug Interaction: Cintarab-SR Capsule may interact with the anti-HIV drug (atazanavir), antifungals (ketoconazole, itraconazole), anticancer drug (methotrexate), heart-related medicine (digoxin), blood thinner (warfarin, clopidogrel), pain reliever (aspirin), anticholinergic drugs (atropine), antipsychotic (phenothiazine), opioid analgesics (morphine, fentanyl), an antidepressant (duloxetine), medicines to treat thyroid (levothyroxine), and vitamin (cyanocobalamin).

Drug-Food Interaction: Cintarab-SR Capsule may interact with St. John’s wort (herbal supplement used to treat depression). Avoid alcohol consumption as alcohol intake leads to increased production of stomach acid, thereby irritates the stomach lining and worsen the symptoms.

Drug-Disease Interaction: If you have a stomach tumour, liver problems, bleeding, low magnesium levels in the blood, osteoporosis (weak and brittle bones), or lupus (an autoimmune disorder), inform your doctor before taking Cintarab-SR Capsule .

• ATAZANAVIR
• KETOCONAZOLE
• ITRACONAZOLE
• METHOTREXATE
• DIGOXIN
• WARFARIN
• CLOPIDOGREL
• ASPIRIN
• ATROPINE
• PHENOTHIAZINE
• MORPHINE
• FENTANYL
• DULOXETINE
• LEVOTHYROXINE
• CYANOCOBALAMIN

• Eat smaller meals more often.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating as it causes acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practice relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

• Regular blood tests are recommended while taking Cintarab-SR Capsule to monitor magnesium levels in the blood.
• Cintarab-SR Capsule may cause some abnormal liver enzyme and blood values. These changes are temporary and may return to normal after treatment with Cintarab-SR Capsule is discontinued.

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers, and heartburn. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (esophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, a sour or bitter taste in the mouth, and difficulty swallowing.

Peptic ulcers: These are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.

Zollinger-Ellison syndrome: It is characterized by the formation of tumors in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.