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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Celginase 10000 Injection is used to treat acute lymphoblastic leukaemia. It contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, it stops the cancer cells from dividing and growing. If you are pregnant or planning pregnancy, please inform your doctor before receiving Celginase 10000 Injection. You are recommended to use effective contraceptive methods before and for at least 3 months after treatment to prevent pregnancy.

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Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Celginase 10000 Injection

Celginase 10000 Injection belongs to the class of medicines called antineoplastic (anticancer) agents used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow.

Celginase 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing. 

Celginase 10000 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Celginase 10000 Injection may cause common side effects such as nausea, weight loss, generalised pain or muscle pain, infections or a decrease in normal blood content. Most of these side effects of Celginase 10000 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to L asparaginase or other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least 3 months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection as it may cause drowsiness or dizziness.

Uses of Celginase 10000 Injection

Treatment of Acute lymphoblastic leukaemia

Directions for Use

Celginase 10000 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Celginase 10000 Injection contains L Asparaginase, an anticancer agent used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). It lowers the levels of asparagine in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing. 

How Celginase 10000 Injection Works

Celginase 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Celginase 10000 Injection

  • Nausea
  • Vomiting
  • Weight loss
  • Generalised pain or muscle pain
  • Infections
  • Swelling at the injection site
  • loss of appetite
  • headache
  • lack of energy
  • drowsiness
  • Stomach cramps

What if I have taken an overdose of Celginase 10000 Injection

Since Celginase 10000 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to L asparaginase or any other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning for pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least three months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection if you experience drowsiness or dizziness. Celginase 10000 Injection may increase the risk of infections. Therefore, consult your doctor if you notice any signs of infection and avoid contact with people having viral infections. If you experience any significant bleeding during treatment with Celginase 10000 Injection, inform your doctor immediately, as Celginase 10000 Injection may affect your body’s ability to prevent excessive bleeding. 

Drug-Drug Interactions

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AsparaginaseLeflunomide
Severe
AsparaginaseLomitapide
Severe

Drug-Drug Interactions

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AsparaginaseLeflunomide
Severe
How does the drug interact with Celginase 10000 Injection 1's:
Taking Celginase 10000 Injection 1's with leflunomide may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between Celginase 10000 Injection 1's and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AsparaginaseLomitapide
Severe
How does the drug interact with Celginase 10000 Injection 1's:
Coadministration of Celginase 10000 Injection 1's and Lopitamide may increase the risk of liver issues.

How to manage the interaction:
Taking Celginase 10000 Injection 1's with Lomitapide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AsparaginaseBexarotene
Severe
How does the drug interact with Celginase 10000 Injection 1's:
The use of Celginase 10000 Injection 1's with bexarotene may raise the risk of inflammation of the pancreas.

How to manage the interaction:
Co-administration of Celginase 10000 Injection 1's with Bexarotene can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you have symptoms such as persistent nausea, vomiting, abdominal soreness, and upper abdominal pain, especially if it worsens after eating or extends to the back. Do not stop using any medications without talking to a doctor.
AsparaginaseNatalizumab
Severe
How does the drug interact with Celginase 10000 Injection 1's:
Taking Celginase 10000 Injection 1's with Natalizumab together can increase the risk of developing serious infections.

How to manage the interaction:
Taking Celginase 10000 Injection 1's with Natalizumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseMipomersen
Severe
How does the drug interact with Celginase 10000 Injection 1's:
Coadministration of Celginase 10000 Injection 1's and Mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Celginase 10000 Injection 1's and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. Call a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
AsparaginaseTeriflunomide
Severe
How does the drug interact with Celginase 10000 Injection 1's:
The use of Celginase 10000 Injection 1's in conjunction with teriflunomide may raise the risk of severe infections, liver problems.

How to manage the interaction:
Co-administration of Celginase 10000 Injection 1's with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseThalidomide
Severe
How does the drug interact with Celginase 10000 Injection 1's:
Taking thalidomide together with Celginase 10000 Injection 1's may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Celginase 10000 Injection 1's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AsparaginaseDalteparin
Moderate
How does the drug interact with Celginase 10000 Injection 1's:
Using dalteparin with Celginase 10000 Injection 1's may increase your risk of blood clots or bleeding.

How to manage the interaction:
Although taking Desogestrel and Fosamprenavir together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily during treatment with Celginase 10000 Injection, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Celginase 10000 Injection Substitute

Substitutes safety advice
  • L-Ginase 10000 IU Injection 1's

    1484.10per tablet
  • Lagicad 10000IU Injection 1's

    1613.70per tablet
  • Aspezex 10000 Injection 1's

    1439.10per tablet
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Alcohol

Caution

Avoid or limit alcohol consumption while on treatment with Celginase 10000 Injection as it may worsen your condition.

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Pregnancy

Consult your doctor

Limited data available on the effect of Celginase 10000 Injection on pregnant women. Hence, if you are pregnant, or planning pregnancy, inform your doctor before receiving Celginase 10000 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the child.

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Driving

Caution

Celginase 10000 Injection may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.

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Liver

Caution

If you have pre-existing or a history of liver disease, inform your doctor before receiving Celginase 10000 Injection. Your doctor may recommend regular tests to monitor liver function while receiving Celginase 10000 Injection.

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Kidney

Caution

If you have pre-existing or a history of kidney disease, inform your doctor before receiving Celginase 10000 Injection. Your doctor may recommend regular tests to monitor kidney function while receiving Celginase 10000 Injection.

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Children

Caution

The dosage for children is recommended based on their age, body weight and condition of the child.

FAQs

Celginase 10000 Injection is used to treat Acute lymphoblastic leukaemia.
Celginase 10000 Injection contains L Asparaginase, an anticancer agent that works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing.
Celginase 10000 Injection may increase blood sugar levels. This can be controlled by receiving insulin. However, if you notice any symptoms such as increased thirst, dry mouth, frequent urination, tiredness, or blurred vision, please inform your doctor, as these might be symptoms of high blood sugar levels.
Celginase 10000 Injection may cause stomach pain in some patients. You are advised to inform your doctor immediately if you have stomach pain, as it may be a sign of pancreatitis (inflammation of the pancreas).
Contact your doctor immediately if you notice signs of infection, severe allergic reactions, unusual bleeding, significant swelling, dizziness, or any unknown symptoms.
While liver damage is rare, severe liver impairment can occur with Celginase 10000 Injection. Liver function should be carefully monitored before and throughout treatment, and if significant liver issues arise, treatment should be discontinued, with immediate medical consultation.
Nausea and extreme tiredness may be side effects of Celginase 10000 Injection, but responses vary. You are recommended to consult your healthcare provider to confirm if these symptoms are related or if another cause is involved.
To get relief from diarrhoea while on Celginase 10000 Injection, ensure proper hydration, eat a mild diet, and avoid irritant foods. If symptoms persist or worsen, consult your doctor for potential treatment adjustments or additional medicines.
If you observe changes in your skin after receiving Celginase 10000 Injection, you are recommended to contact your doctor. They can evaluate whether the changes are due to Celginase 10000 Injection and advise the necessary course of action. Do not take any other medicine unless advised by a doctor.
Yes, you should inform your doctor about the swelling and frequent muscle cramps, as these could be side effects or signs of an underlying issue. Your doctor can assess the situation and make any necessary adjustments to your treatment to prevent further complications.
You can generally maintain your regular diet unless advised by your doctor. However, you are recommended to stay hydrated by drinking water regularly, and eating small, simple meals throughout the day instead of large ones, to help prevent nausea and vomiting.
During your treatment with Celginase 10000 Injection, avoid breastfeeding as there may be risks to feeding the child. Prevent driving a vehicle if you are feeling drowsy or dizzy. Avoid contact with those who have viral infections. Limit caffeine, fatty, spicy, or overly sweet foods to prevent nausea and avoid alcohol intake and smoking. Consult a doctor if you have any concerns or if any signs of infection occur.
Celginase 10000 Injection causes side effects such as nausea, vomiting, weight loss, muscle pain, loss of appetite, headache, lack of energy, drowsiness, and stomach pain. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - CEL0177

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