Celginase 10000 Injection belongs to the class of medicines called antineoplastic (anticancer) agents used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow.

Celginase 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing. 

Celginase 10000 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Celginase 10000 Injection may cause common side effects such as nausea, weight loss, generalised pain or muscle pain, infections or a decrease in normal blood content. Most of these side effects of Celginase 10000 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to L asparaginase or other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least 3 months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection as it may cause drowsiness or dizziness.

Celginase 10000 Injection contains L Asparaginase, an anticancer agent used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). It lowers the levels of asparagine in the body, which is necessary for the survival of cancer cells. Thus, Celginase 10000 Injection stops the cancer cells from dividing and growing. 

• Nausea
• Vomiting
• Weight loss
• Generalised pain or muscle pain
• Infections
• Swelling at the injection site
• loss of appetite
• headache
• lack of energy
• drowsiness
• Stomach cramps

If you are allergic to L asparaginase or any other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Celginase 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning for pregnancy, please inform your doctor before receiving Celginase 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least three months after treatment with Celginase 10000 Injection to prevent pregnancy. Celginase 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Celginase 10000 Injection if you experience drowsiness or dizziness. Celginase 10000 Injection may increase the risk of infections. Therefore, consult your doctor if you notice any signs of infection and avoid contact with people having viral infections. If you experience any significant bleeding during treatment with Celginase 10000 Injection, inform your doctor immediately, as Celginase 10000 Injection may affect your body’s ability to prevent excessive bleeding. 

Drug-Drug Interaction: Inform your doctor if you are taking other anticancer drugs (cytarabine, methotrexate, vincristine), corticosteroids (prednisone) and oral contraceptives. 

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Celginase 10000 Injection is not given if you have or previously had severe pancreatitis.

• CYTARABINE
• METHOTREXATE
• VINCRISTINE
• PREDNISONE

• Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
• Drink plenty of water daily during treatment with Celginase 10000 Injection, as some cancer therapies may cause dehydration.
• Exercise regularly and maintain a healthy body weight.
• Regularly wash your hands and avoid contact with people having infections.
• Quit smoking.

• Your doctor will monitor you closely during and after treatment with Celginase 10000 Injection for normal blood content, allergic reactions, and kidney, pancreas and liver functions.

Acute lymphoblastic leukaemia (ALL): It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow. It is the most common childhood cancer. The symptoms include bleeding from gums, weakness, bone pain, joint pain, bruises, extreme tiredness, paleness, enlarged lymph nodes in the neck, groin region or under the arms, fever or shortness of breath. The risk factors include exposure to high levels of radiation, viral infections, inherited syndromes, smoking, prolonged exposure to certain chemicals or chemotherapy drugs or even diesel.