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  3. Celdaz 500 Injection 1's

Celdaz 500 Injection 1's, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Celdaz 500 Injection is used to treat skin cancer. It contains Dacarbazine, an alkylating agent that inhibits the DNA and RNA transcription essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells. Celdaz 500 Injection may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the injection site.

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Composition :

DACARBAZINE-500MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Celdaz 500 Injection

Celdaz 500 Injection is a chemotherapeutic medicine used in the treatment of skin cancer. Cancer is a condition where the cells grow and reproduce uncontrollably in a specific body part. These cancerous cells can attack and destroy surrounding healthy tissue and organs. Celdaz 500 Injection is used in the treatment of metastatic malignant melanoma. It is a serious condition in which the cancer grows in melanocytes and also spreads to other parts of the body. Celdaz 500 Injection is also used as a second-line therapy in the treatment of Hodgkin’s Disease when used in combination with other approved drugs.

Celdaz 500 Injection contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Celdaz 500 Injection may cause certain side effects, such as nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Celdaz 500 Injection is a parenteral preparation. A trained healthcare professional will administer it. 

Celdaz 500 Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including medications you take, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or heart problems. Celdaz 500 Injection may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring of blood and liver functioning should be done during the entire treatment. This medicine is known to cause fetal harm if used in pregnancy. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding before taking Celdaz 500 Injection.

Uses of Celdaz 500 Injection

Treatment of Metastatic Malignant Melanoma and Hodgkin's Disease

Directions for Use

Celdaz 500 Injection will be administered by a trained healthcare professional. Hence, do not self-administer. 

Medicinal Benefits

Celdaz 500 Injection contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

How Celdaz 500 Injection Works

Celdaz 500 Injection contains Dacarbazine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Celdaz 500 Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

What if I have taken an overdose of Celdaz 500 Injection

Since Celdaz 500 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Celdaz 500 Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease or cardiac disorders. Celdaz 500 Injection may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women and breastfeeding mothers. Hence, inform your doctor if you are pregnant, planning to become pregnant and breastfeeding. It is unknown whether Celdaz 500 Injection can be administered to children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DacarbazineEtanercept
Severe
DacarbazineClozapine
Severe

Drug-Drug Interactions

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DacarbazineEtanercept
Severe
How does the drug interact with Celdaz 500 Injection:
When Etanercept is used with Celdaz 500 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Celdaz 500 Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DacarbazineClozapine
Severe
How does the drug interact with Celdaz 500 Injection:
Combining Celdaz 500 Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although taking Celdaz 500 Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
DacarbazineBaricitinib
Severe
How does the drug interact with Celdaz 500 Injection:
Coadministration of Celdaz 500 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Celdaz 500 Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineKetoconazole
Severe
How does the drug interact with Celdaz 500 Injection:
When Celdaz 500 Injection is taken with Ketoconazole, it can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Celdaz 500 Injection and Ketoconazole, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
DacarbazineThalidomide
Severe
How does the drug interact with Celdaz 500 Injection:
Taking thalidomide together with Celdaz 500 Injection may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Celdaz 500 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DacarbazineCladribine
Severe
How does the drug interact with Celdaz 500 Injection:
The combined use of cladribine with Celdaz 500 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Celdaz 500 Injection and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DacarbazineInfliximab
Severe
How does the drug interact with Celdaz 500 Injection:
When Celdaz 500 Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Celdaz 500 Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DacarbazineTofacitinib
Severe
How does the drug interact with Celdaz 500 Injection:
Taking Celdaz 500 Injection with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Celdaz 500 Injection and Tofacitinib, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid going out in the hot sun, as it can harm your skin.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Celdaz 500 Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Celdaz 500 Injection to prevent serious side effects.

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Pregnancy

Unsafe

Celdaz 500 Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Celdaz 500 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Celdaz 500 Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Celdaz 500 Injection will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Celdaz 500 Injection. It may cause hepatic necrosis when administered with other antineoplastics. Hence, Celdaz 500 Injection should be used with caution in patients with liver problems. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Celdaz 500 Injection. It should be used with caution in patients with renal impairment. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Limited information is available for the use of Celdaz 500 Injection in children. It will be administered to the children only if clearly needed. If administered, careful monitoring of the child is needed.

Have a query?

FAQs

Celdaz 500 Injection is used to treat Metastatic Malignant Melanoma and Hodgkin’s Disease.

Celdaz 500 Injection contains Dacarbazine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Celdaz 500 Injection may cause hemopoietic (bone marrow) depression, hepatic toxicity, and hepatic necrosis in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Celdaz 500 Injection is administered intravenously by a trained healthcare professional. Hence, do not self-administer.

Celdaz 500 Injection is not a potent vesicant. Celdaz 500 Injection is a chemotherapeutic medicine used in the treatment of skin cancer.

Celdaz 500 Injection works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Celdaz 500 Injection may cause hair loss. Tell your doctor if it is severe or does not go away.

The common side effects of Celdaz 500 Injection may include nausea, vomiting, headache, dizziness, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - CEL0280

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:35 AM IST

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Reference

  1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=26e91082-7698-4680-beab-07c47802f0f9
  2. https://reference.medscape.com/drug/dtic-dome-dacarbazine-342215
  3. https://www.lls.org/drug/dacarbazine
  4. https://www.drugs.com/pro/dacarbazine.html#s-34068-7
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